Protein Alignment mwh and FMNL3

DIOPT Version :9

• Sequence 1: NP_001261244.1
• Gene: mwh / 38131
• FlyBaseID: FBgn0264272
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: XP_011537270.1
• Gene: FMNL3 / 91010
• HGNCID: 23698
• Length: 1047
• Species: Homo sapiens
• Alignment Length: 654
• Identity: 127/654 - (19%)
• Similarity: 227/654 - (34%)
• Gaps: 198/654 - (30%)

  Fly   225 GQLGQLHLEMAPSVCEMAGQGQSGPVP--------PQKASGSNSSKGTNKCGASSLNGSLASYKI 281
            |:..:.||. |..:||    |..|..|        |..:||..||.......|..|.    .|
Human    24 GKWCRWHLS-ARQLCE----GPKGCGPYILWPSAFPPASSGDRSSMNLPPDKARLLR----QY-- 77

  Fly   282 GGSEQSWPQAPVYSKENQRPPVYN-PEDYVHSLRKFIKASGSAKKLSIYDVFTGPSPKEEASRSA 345
             .:|:.|.    ...:.:|..|.| |..|:..|:.|:..|.:.||..
Human    78 -DNEKKWD----LICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFR------------------ 119

  Fly   346 TLPAKHSEYKSPIPAPPENDREMSLRQFGSITDLLTKLRADLRVSFPSFVQEFVGTPADGISHLL 410
                                     |:....|.:|.:|...||.:...:|:||:.....|:..|:
Human   120 -------------------------RRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLV 159

  Fly   411 EVL-----------------------------RAIQMAQASNA-PAPMPGASSSLAMNRNPQSYQ 445
            :.|                             |:|:..|..:| .||.   ::|||.:......:
Human   160 DYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPSALSAPF---TNSLARSARQSVLR 221

  Fly   446 ------RRALL---------DELSCLQCLSICCSRSLDAIARLGNTPVGLMPLASSATGQGIRAR 495
                  ||||.         |...|:.||....:... ....:.:.|..:..:|.|...:..|.:
Human   222 YSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQY-GFNLVMSHPHAVNEIALSLNNKNPRTK 285

  Fly   496 ILALQLLASACDRQPFGSGSGGQKIASAGHTAVSDAMSTLRLRCSEPVRFRLLVGILNSGGGSGE 560
            .|.|:|||:.|             :...||..:..|....:..|.|..||..|:....:...:.:
Human   286 ALVLELLAAVC-------------LVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNID 337

  Fly   561 LQCAGVKFLNTFIESAVSIQQRLYIQAELFQAGLDASTLARTISSSSPWLDALKIEVKRFNELHI 625
            ...|.::|:|..:.|...:..|:::|.|..:.||: ..|.::..:.|   :.|:::::.:.:...
Human   338 FMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLE-EFLQKSRHTES---EKLQVQIQAYLDNVF 398

  Fly   626 DVDQMITRARDAERVRSQMVILERRVQILHEEKAVLT----SMERRLQERCAELQREIFRLQGTQ 686
            ||..::   .|||   ::.|.|| :|:.|.|..:.||    .:|.....|.|||::::.:.:...
Human   399 DVGGLL---EDAE---TKNVALE-KVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKEL 456

  Fly   687 QQSKFKPVESSHQPVALPRQVPPPKKNKQNSSEHEDEGISSSETGASLSPVPILILPSKAKPSRK 751
            :..|.....:|||...|                                              |:
Human   457 ESIKETYENTSHQVHTL----------------------------------------------RR 475

  Fly   752 VVEEDED---DAATIEDVIEELDNIVSEAEKQISSQTSSVTRP----KMRHHRPVEKEIVPVNIV 809
            :::|.|:   ....:|..:..|:::.|||..::.....|...|    .:....|..:|::|:...
Human   476 LIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPP 540

  Fly   810 PQPP 813
            |.||
Human   541 PAPP 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mwh	NP_001261244.1	Drf_GBD	<380..506	CDD:283920	36/170 (21%)
		Drf_FH3	524..725	CDD:283917	43/204 (21%)
FMNL3	XP_011537270.1	Drf_GBD	64..297	CDD:283920	54/303 (18%)
		Drf_FH3	300..497	CDD:283917	47/253 (19%)
		FH2	580..945	CDD:280362

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1923
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45857
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.870