Protein Alignment mwh and Fmnl2

DIOPT Version :10

• Sequence 1: NP_001261244.1
• Gene: mwh / 38131
• FlyBaseID: FBgn0264272
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: XP_006498393.1
• Gene: Fmnl2 / 71409
• MGIID: 1918659
• Length: 1098
• Species: Mus musculus
• Alignment Length: 932
• Identity: 177/932 - (18%)
• Similarity: 297/932 - (31%)
• Gaps: 321/932 - (34%)

  Fly   199 MFEAGKSMVDSDSSTLQRHH-----PQPRHPGQLGQLHLEMAPSVCEMAGQGQSGPVPPQKASGS 258
            |..||.  :||..:..:.|:     |.| .||:|.:....:..::          .:||.||.
Mouse     1 MGNAGS--MDSQQTDFKAHNVPLKLPMP-EPGELEERFAIVLNAM----------NLPPDKAR-- 50

  Fly   259 NSSKGTNKCGASSLNGSLASYKIGGSEQSWPQAPVYSKENQRPPVYN-PEDYVHSLRKFIKASGS 322
                            .|..|   .:|:.|.    ...:.:|..|.| |..|:..|:.::..:.:
Mouse    51 ----------------LLRQY---DNEKKWE----LICDQERFQVKNPPHTYIQKLKGYLDPAVT 92

  Fly   323 AKKLSIYDVFTGPSPKEEASRSATLPAKHSEYKSPIPAPPENDREMSLRQFGSITDLLTKLRADL 387
            .||..                                           |:....|.:|.:|...|
Mouse    93 RKKFR-------------------------------------------RRVQESTQVLRELEISL 114

  Fly   388 RVSFPSFVQEFVGTPADGISHLLEVLRAIQMA------------------------------QAS 422
            |.:...:|:||:.....|:..|:|.|...|.|                              :.|
Mouse   115 RTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGS 179

  Fly   423 NAPAPM------PGASSSLAMNRNPQSYQRRALL---------DELSCLQCLSICCSRSLDAIAR 472
            |.|:|:      .|..|:|..|..|   .||.|.         |...|:.||....:... ....
Mouse   180 NLPSPVGNSVSRSGRHSALRYNTLP---SRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQY-GFNM 240

  Fly   473 LGNTPVGLMPLASSATGQGIRARILALQLLASACDRQPFGSGSGGQKIASAGHTAVSDAMSTLRL 537
            :.:.|..:..:|.|...:..|.:.|.|:|||:.|             :...||..:..|....:.
Mouse   241 VMSHPHAVNEIALSLNNKNPRTKALVLELLAAVC-------------LVRGGHEIILSAFDNFKE 292

  Fly   538 RCSEPVRFRLLVGILNSGGGSGELQCAGVKFLNTFIESAVSIQQRLYIQAELFQAGLD--ASTLA 600
            .|.|..||..|:....:...:.:...|.::|:|..:.|...:..|:::|.|..:.|||  ...|.
Mouse   293 VCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLK 357

  Fly   601 RTISSSSPWLDALKIEVKRFNELHIDVDQMITRARDAERVRSQMVILERRVQIL--------HEE 657
            .|.|      |.|:::::.:.:...||..::..|........::..||..:..|        :|.
Mouse   358 HTES------DKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEA 416

  Fly   658 KAVLTSMERRLQERCAELQ--REIFRLQGTQQQSKFKPVESSHQPVALPRQVPPPKK----NKQN 716
            .:.:..:|::|.:|..||.  |||::...||..:..|.|:...:  |:.||....||    .||.
Mouse   417 MSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEE--AIQRQSTLEKKIHELEKQG 479

  Fly   717 SSEHEDEGISSSETGASLSPVPILILPSKAKPSRKVVEEDEDDAATIEDVIEELDNIVSEAEKQI 781
            :.:.:.:|...           |.|||..|.                       ..:.:.:|..:
Mouse   480 TIKIQKKGDGD-----------IAILPVMAS-----------------------GTLSTGSELAV 510

  Fly   782 SSQTSSVTRPKMRHHRPVEKEIVPVNIVPQPPRKSRSLAHLVPRTDCSD--QEGSDYGMVLHQPA 844
            .:...||  |......|        ::.|.||        |.|.:|.|:  |.|:....:...|.
Mouse   511 GNYVGSV--PGATTSGP--------SVPPPPP--------LPPSSDTSEAAQNGTASPPMSPPPP 557

  Fly   845 DP---------------DAAERLAAMQSFFDEVDYDAPETDQPAAYQMESPTPDMPEANATATAY 894
            .|               .|||...|.         ..|....|:|       |.:|..::....:
Mouse   558 PPPPPPPPPPPPPPLPGPAAETSPAP---------PLPPPPPPSA-------PPLPGTSSPTVVF 606

  Fly   895 NASTNRELLDVIMNARHDDHDPTMQALRKSVQDAAPVTIPHHPVKVKAPAPPPPTPPA------- 952
            |:.    |.|                        .|:.:  ..||:|.|.......|.
Mouse   607 NSG----LAD------------------------GPIKL--FSVKIKKPIKTKFRMPVFNWVALK 641

  Fly   953 -QQFNGVFF--------MTGMN---------TPQKYPKPDISAALQ--ARRVTKNVERLEAAFAS 997
             .|.||..|        :..:|         |..:.|..|:|::.|  .::.:..|..|||
Mouse   642 PNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEA---- 702

  Fly   998 AHPEALNEAAIGREKSRSNQQI 1019
              ..|.|.|...|:..:|..:|
Mouse   703 --NRAKNLAITLRKAGKSADEI 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mwh	NP_001261244.1	Drf_GBD	<349..506	CDD:461886	40/201 (20%)
		Drf_FH3	524..725	CDD:461885	49/216 (23%)
Fmnl2	XP_006498393.1	Drf_GBD	23..275	CDD:461886	62/347 (18%)
		Drf_FH3	278..475	CDD:461885	47/204 (23%)
		FH2	622..973	CDD:396655	23/107 (21%)