Protein Alignment mwh and fmnl1

DIOPT Version :10

• Sequence 1: NP_001261244.1
• Gene: mwh / 38131
• FlyBaseID: FBgn0264272
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_001007523.1
• Gene: fmnl1 / 493573
• XenbaseID: XB-GENE-1003193
• Length: 1167
• Species: Xenopus tropicalis
• Alignment Length: 912
• Identity: 182/912 - (19%)
• Similarity: 307/912 - (33%)
• Gaps: 247/912 - (27%)

  Fly   243 GQGQSGPVPPQKASGSNSSK--GTNKCGASS-----LNG-SLASYKIG-----GSEQSWPQAPVY 294
            ||..|| .||||......||  ..|......     ||. :|...||.     ..::.|...
 Frog    18 GQSTSG-TPPQKQKEGTPSKLPRPNSVELEQRFNVVLNAMNLPPDKIQVLRQYDQDKKWELV--- 78

  Fly   295 SKENQRPPVYN-PEDYVHSLRKFIKASGSAKKLSIYDVFTGPSPKEEASRSATLPAKHSEYKSPI 358
             .:.:|..|.| |..|:..||.::...|.::|..
 Frog    79 -CDQERFQVKNPPAAYIQKLRSYLDTGGISRKFK------------------------------- 111

  Fly   359 PAPPENDREMSLRQFGSITDLLTKLRADLRVSFPSFVQEFVGTPADGISHLLEVL---------- 413
                        |:....|.:|.:|...||.:...:|:||:.....|:..|:|.|
 Frog   112 ------------RRVQESTQVLRELEISLRTNHIGWVEEFLSPEVGGLDALVEYLSYAQGSCPID 164

  Fly   414 ------------RAIQMA-----QASNAPAP--MPGASSSLA--MNRNPQSYQRRA----LLDEL 453
                        :::|.:     ::|::|:|  .|..|.:|.  .|.:.:|..|..    :.|::
 Frog   165 TECSDNGTPEKSKSLQRSLEDINKSSSSPSPTNTPSRSRNLTARYNLHSRSTMRNTKHANMKDDV 229

  Fly   454 S-CLQCL-SICCSRSLDAIARLGNTPVGLMPLASSATGQGIRARILALQLLASACDRQPFGSGSG 516
            . |:.|| :|...:|..::....::.|..:.|  |.:.:..|.:.|.|:|||:.|
 Frog   230 HVCIMCLRAIMNYQSGFSMVMSHSSCVNKITL--SLSNKNPRTKALVLELLAAVC---------- 282

  Fly   517 GQKIASAGHTAVSDAMSTLRLRCSEPVRFRLLVGILNSGGGSGELQCAGVKFLNTFIESAVSIQQ 581
               :...||..:..|.:.....|.|..||..|:....:...:.:...|.::|:|..:.|..::..
 Frog   283 ---LVRGGHELILSAFNYFMEMCGEGARFEKLMEYFRTEDSNIDFMVACMQFINIVVHSVKNMNF 344

  Fly   582 RLYIQAELFQAGLD--ASTLARTISSSSPWLDALKIEVKRFNELHIDVDQMITRARDAERVRSQM 644
            |:::|.|....|||  ...|..|.|      :.|:::::.:.:...||:.::   .|.: .:::|
 Frog   345 RVFLQYEFTLLGLDEYLEILKNTES------ERLQVQIQAYLDNIFDVNSLL---EDTD-TKNEM 399

  Fly   645 VILERRVQILHE------EKAVLTSMERRLQERCAELQREIFRLQGTQQQSKFKPVESSHQPV-- 701
            :   ..|:.|.|      ||..||  |.....|.|||::::.:.:.....:|.|.|..:.|..
 Frog   400 L---EHVEDLQEHLTRVTEKLQLT--ENEYVRRVAELEKQLDQCRREMSSAKEKLVVQAPQVTQN 459

  Fly   702 ------ALPRQVPPPKKNKQNSSEHEDEGISSSETGASLSPVPI--------LILPS----KAKP 748
                  .:.|.|...:......:|...:...:|:..::.|..|:        ||.||    .|..
 Frog   460 IVQRTELVKRSVLWVEPAGDTCTEEISDNTFTSDLPSAASTPPLSPSAIRITLISPSVTSTDALS 524

  Fly   749 SRKVVEEDEDDAATIEDVIEELDNIVSEAEKQI-SSQTSSVTRPKMRHHRPVEKEIVPVNIVPQP 812
            ||..........|.:..:.|..:.....|...: ||:.||.|..|..          .||.||.|
 Frog   525 SRGNSPRSTTPPALLPSLPESSEIFSIPAPSPVPSSEDSSDTALKAS----------KVNPVPSP 579

  Fly   813 PRKSRSLAHLVPRTDCSDQEGSDYGMVLHQ----PADPDAAERLAAMQSFFDEVDYDAPETDQPA 873
            |       .::.:|..|:.:....   .|.    |..|.....:|              |...|.
 Frog   580 P-------SIIDQTQTSNAQSLSR---THDESPPPPPPPPLPSIA--------------EIPPPP 620

  Fly   874 AYQMES---PTPDMPEANATATAYNASTNRELLDVIMNARHDDHDPTMQALRKSVQDAAPVTIPH 935
            ...|.:   |.|.:||.:..                         |....|....|.|.|
 Frog   621 PLPMSADVPPPPPLPELSGI-------------------------PPPPPLPMGEQGAPP----- 655

  Fly   936 HPVKVKAP-APPPPTPPAQQFNGVFFMTGMNTPQKYPKPDISAALQARRVTKNVERLEAAFASAH 999
            .|..:.|| .||||.||...|.          |...|.|   ....|..:...|...:.......
 Frog   656 PPPSMGAPGVPPPPPPPPSGFG----------PAPPPPP---GGQPAATLNTGVSIKKPIQTKLR 707

  Fly  1000 PEALNEAAIGREKSRSNQQIYFTSNLAMRMHDHSGFANSSGGQIQGPTLRTRS----HTQGSMSK 1060
            .:.||..|:...:.......:......::..|.|.|..:...:.|||:..|.|    ..|...:|
 Frog   708 MQVLNWVALKPTQINGTVFTHLNDEKVLQELDMSDFEENFKTKAQGPSQTTFSMKVKAAQNQPNK 772

  Fly  1061 VT 1062
            |:
 Frog   773 VS 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mwh	NP_001261244.1	Drf_GBD	<349..506	CDD:461886	38/193 (20%)
		Drf_FH3	524..725	CDD:461885	45/216 (21%)
fmnl1	NP_001007523.1	Drf_GBD	37..283	CDD:461886	55/307 (18%)
		Drf_FH3	286..>423	CDD:461885	34/151 (23%)
		FH2	698..1064	CDD:396655	14/77 (18%)