Protein Alignment mwh and fmnl3

DIOPT Version :10

• Sequence 1: NP_001261244.1
• Gene: mwh / 38131
• FlyBaseID: FBgn0264272
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_001333083.1
• Gene: fmnl3 / 407694
• ZFINID: ZDB-GENE-030131-1571
• Length: 1047
• Species: Danio rerio
• Alignment Length: 1068
• Identity: 198/1068 - (18%)
• Similarity: 340/1068 - (31%)
• Gaps: 409/1068 - (38%)

  Fly   210 DSSTLQRHHPQPRHPGQLGQLHLEMAPSVCEMAGQG----QSGPVPPQKASGSNSSKGTNKCGAS 270
            |..:..:||..|        |.:.| |...|:..:.    .|..:||.||.
Zfish     8 DGQSEMKHHIMP--------LKVPM-PDPTELEERFAIVLNSMNLPPDKAR-------------- 49

  Fly   271 SLNGSLASYKIGGSEQSWPQAPVYSKENQRPPVYN-PEDYVHSLRKFIKASGSAKKLSIYDVFTG 334
                .|..|   .:|:.|.    ...:.:|..|.| |..|:..||.::
Zfish    50 ----LLRQY---DNEKKWD----LICDQERFQVKNPPHTYIQKLRGYL----------------- 86

  Fly   335 PSPKEEASRSATLPAKHSEYKSPIPAPPENDREMSLRQFGSITDLLTKLRADLRVSFPSFVQEFV 399
                                      .|:..|:...|:....|.:|.:|...||.:...:|:||:
Zfish    87 --------------------------DPKVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFL 125

  Fly   400 GTPADGISHLLEVLRAIQMAQASNAPAPMPGASSSLAMNRNPQSYQRRALLDELSCLQCLSICCS 464
            .....|:..|:|.|...|.|...:......|...||   ...:|:.|.  :::|....|.::..|
Zfish   126 NDENRGLDILVEYLSFAQCAVMLDFEGLENGEDFSL---DKAKSWSRS--IEDLHQNGCNTLVRS 185

  Fly   465 RSLDAIARLGNTP------------------VGLM-----------------------PLASSAT 488
             :..::.|.|:|.                  |.:|                       .:|.|..
Zfish   186 -ARQSVLRYGSTSNSKTIKNSRLVSQKDDVHVCIMCLRAIMNYQYGFNLVMSHAHAVNEIALSLN 249

  Fly   489 GQGIRARILALQLLASACDRQPFGSGSGGQKIASAGHTAVSDAMSTLRLRCSEPVRFRLLVGILN 553
            .:..|.:.|.|:|||:.|             :...||..:..|....:..|.|..||..|:....
Zfish   250 NKNPRTKALVLELLAAVC-------------LVRGGHEIILSAFDNFKEVCKEKHRFEKLMEYFR 301

  Fly   554 SGGGSGELQCAGVKFLNTFIESAVSIQQRLYIQAELFQAGLDASTLARTISSSSPWLDALKIEVK 618
            |..|:.:...|.::|:|..:.|...:..|:::|.|..:.||| ..|.::..:.|   |.|.::::
Zfish   302 SEDGNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLD-DFLEKSKHTES---DKLSVQIQ 362

  Fly   619 RFNELHIDVDQMITRARDAE-----------------RVRSQMVILERRV---------QILHEE 657
            .:.:...||..::   .|||                 .|..:::.:|...         |:||::
Zfish   363 AYLDNVFDVGGLL---EDAETKNVALEKVEELEEHLSHVTEKLLDVENETMTKVADLEKQLLHKD 424

  Fly   658 K--AVLT-----------SMERRLQERCAELQR------EIFRL--QGTQQQSK----------- 690
            |  ||:.           ::.|.:||:.|..||      ::..|  |||.:..|
Zfish   425 KELAVIKETYESASTQVHTLRRMIQEKDAAFQRHNNIEKQLLELEQQGTIRLRKQPDGDIAIETL 489

  Fly   691 ------------------------------FKPVESSHQPVALPRQVPPPKKNKQNSSEHEDEGI 725
                                          ..|||:...|...|...|||.......||.|...|
Zfish   490 GAGAVAGTPLTDLRSLTVGMSTIGGLGGTSAVPVEAVAPPPPPPPPPPPPPPAPPLPSEVESIPI 554

  Fly   726 SSSETGASLSPVPILIL-----------PSKA------------KPSR---KVVEEDEDDAATIE 764
            ..........|.|.:||           |.|.            ||::   .|..|.:||.
Zfish   555 PPPPPPPLPGPSPSVILSVGLSAIRIKKPIKTKFRLPVFNWTALKPNQINGTVFNEIDDDR---- 615

  Fly   765 DVIEELD----------------------------NIVSEAEKQISSQTSSVTRPKMRHHRPVEK 801
             |:||||                            .::::.:...::::.::.....:.::..|:
Zfish   616 -VLEELDLEKFEELFKTKAQGPVVDLSCSKSKVSQKVINKVQLLDANRSKNLAITLRKANKTTEE 679

  Fly   802 ----------EIVPVNIVPQPPRKSRSLAHLVPRTDCSDQEGSDY---GMVLHQPADPD------ 847
                      :.:||:.|       ..|...:| |:...:....|   ...|.|.|:.|
Zfish   680 ICKAIQTFDLKALPVDFV-------ECLMRFLP-TEAESKLLRQYERERRPLDQLAEEDRFMLLF 736

  Fly   848 -AAERLAAMQS-------FFDEVDYDAPETDQPAAYQMESPTPDMPEANATATAYNASTNRELLD 904
             ..|||....|       |.|.|:...|:.:...|              |:|:..::...:::|:
Zfish   737 SKIERLTQRMSIITFVGNFNDNVNMLTPQLNAIIA--------------ASASVKSSPKLKKILE 787

  Fly   905 VI------MNA--RHDDHDPTMQAL-----RKSVQDAAPVTIPHH---PVKVKAPAPPPPTPPAQ 953
            :|      ||:  |...:...:|:|     .||..  ..:|:.|:   .||.|.|      ..|.
Zfish   788 IILALGNYMNSSKRGSVYGFKLQSLDLLLDTKSTD--RKMTLLHYIALVVKEKYP------ELAN 844

  Fly   954 QFNGVFFMTGMNTPQKYPKPDISAALQARRVTKNVERLEAAFASAHPEALNEAAIGREKSRSNQQ 1018
            .:|.:.|:            |.:||:....|..:|:.|....          ..:.||.|
Zfish   845 FYNELHFV------------DKAAAVSLENVLLDVKELGKGM----------DLVRRECS----- 882

  Fly  1019 IYFTSNLAMRMHDHS---GFANSSGGQI 1043
                      :|||:   |||.:|..|:
Zfish   883 ----------LHDHAVLKGFAQTSDTQL 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mwh	NP_001261244.1	Drf_GBD	<349..506	CDD:461886	38/197 (19%)
		Drf_FH3	524..725	CDD:461885	59/288 (20%)
fmnl3	NP_001333083.1	Drf_GBD	23..268	CDD:461886	58/332 (17%)
		Drf_FH3	271..462	CDD:461885	43/197 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	520..561		12/40 (30%)
		FH2	580..945	CDD:396655	71/393 (18%)
		CwlO1	<941..>999	CDD:443091