DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mwh and Fmnl1

DIOPT Version :9

Sequence 1:	NP_001261244.1	Gene:	mwh / 38131	FlyBaseID:	FBgn0264272	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_006247560.1	Gene:	Fmnl1 / 287746	RGDID:	1311042	Length:	1101	Species:	Rattus norvegicus

Alignment Length:	880	Identity:	166/880 - (18%)
Similarity:	278/880 - (31%)	Gaps:	258/880 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 APSVCEMAGQGQSGP----VP--PQKASGSNSSKGTNKCGASSLNGS----LASYKIGGSEQSWP 289
            |.|..:.||...|.|    ||  |..|:|....:.|......:|...    |:.|   .:|:.|.
  Rat     5 AGSAEQPAGPTASPPKQPAVPKQPMPAAGELEERFTRVLNCMNLPPDKVQLLSQY---DNEKKWE 66

  Fly   290 QAPVYSKENQRPPVYN-PEDYVHSLRKFIKASGSAKKLSIYDVFTGPSPKEEASRSATLPAKHSE 353
                ...:.:|..|.| |..|:..|:.::...|.::|:                  ||....:..
  Rat    67 ----LICDQERFQVKNPPAAYIQKLKSYLDTGGVSRKV------------------ATDWMSNLG 109

  Fly   354 YKSPIPAPPENDREMSLRQFGSITDLLTKLRADLRVSFPSFVQEFVGTPADGISHLLEVLR---- 414
            :|               |:....|.:|.:|...||.:...:||||:.....|:..|||.|.
  Rat   110 FK---------------RRVQESTQVLRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQC 159

  Fly   415 --AIQMAQASNA---------------------PAPMPGASSSLAMNRNPQ---SYQRRALL--- 450
              |..|....|.                     |:.:|.:..::....:|:   ::.|:||.
  Rat   160 SVAYDMESTENVASGTEKNKPLEQSVEDLSKAPPSSVPKSRLTIKCPPSPRLTPAHSRKALRNSR 224

  Fly   451 ------DELSCLQCLSICCSRSLDAIARLGNTPVGLMPLASSATGQGIRARILALQLLASACDRQ 509
                  |...|:.||....:.. ...:.:.|.|..:..:|.|...:..|.:.|.|:|||:.|
  Rat   225 IVSQKDDVHVCIMCLRAIMNYQ-SGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVC--- 285

  Fly   510 PFGSGSGGQKIASAGHTAVSDAMSTLRLRCSEPVRFRLLVGILNSGGGSGELQCAGVKFLNTFIE 574
                      :...||..:..|....:..|.|..||..|:....:...:.:...|.::|:|..:.
  Rat   286 ----------LVRGGHDIILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVH 340

  Fly   575 SAVSIQQRLYIQAELFQAGLDASTLARTISSSSPWLDALKIEVKRFNELHIDVDQMITRARDAER 639
            |..::..|:::|.|....|||.......::.|    |.|:::::.:.:...||..::........
  Rat   341 SVENMNFRVFLQYEFTHLGLDLYLERLRLTES----DKLQVQIQAYLDNVFDVGTLLEETETKNA 401

  Fly   640 VRSQMVILERRVQILHEEKAVLTSMERRLQERCAELQREIFRLQGTQQQSKFKPVESSHQPVALP 704
            |...|..|:.:|..|.|.   |...|.....:.|||::::  .|..::....:...|...|:...
  Rat   402 VLEHMEELQEQVATLTER---LRDTENDSMAKIAELEKQL--SQARKELETLRERFSESTPMVTS 461

  Fly   705 RQVPPPKKNKQNSSEHEDEGISSSETGASLSPVPILILPSKAKPSRKVVEEDE----------DD 759
            |::|.|:|                      .|.|.::.||..:  .||.|.:|          .|
  Rat   462 RRIPEPEK----------------------VPAPTVVRPSALE--LKVEELEEKGLIRILRGPGD 502

  Fly   760 AATIEDVIEELDNIVSEAEKQISSQTSSVTRPKMRHHRPVEKEIVPVNIVPQPPRKSRSLAHLVP 824
            ..:||        |:..|....|...:..  |::....|...|.||....|.||
  Rat   503 VVSIE--------ILPGAAATPSGDDAPA--PRVSTDSPSTAESVPEAASPTPP----------- 546

  Fly   825 RTDCSDQEGSDYGMVLHQPADPDAAERLAAMQSFFDEVDYDAPETDQPAAYQMESPTPDMPEANA 889
                            ..|..|.....|.:.|.........||.....||   ..|.|.:|
  Rat   547 ----------------PPPPPPPPLPNLQSQQEALPSAPPLAPPLPGCAA---PPPAPPLP---- 588

  Fly   890 TATAYNASTNRELLDVIMNARHDDHDPTMQALRKSVQDAAPVTIPHHPVKVKAPAPPPPTPPAQQ 954
                                                 ...|...|..|:....|.||||.||
  Rat   589 -------------------------------------GDLPPPPPPPPLGTDGPVPPPPPPP--- 613

  Fly   955 FNGVFFMTGMNTPQKYP------KPDISAALQARRVTKNVERLEAAFASAHPEALNEAAIGREKS 1013
                        |...|      .|:|...::|::..:...|:         ..||..|:...:.
  Rat   614 ------------PGGPPDILGGQDPEIGPGVKAKKPIQTKFRM---------PLLNWVALKPSQI 657

  Fly  1014 RSNQQIYFTSNLAMRMHDHSGFANSSGGQIQGPTL 1048
            .............::..|.:.|......:.|||:|
  Rat   658 TGTVFTELNDEKVLQELDMNDFEEQFKTKSQGPSL 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mwh	NP_001261244.1	Drf_GBD	<380..506	CDD:283920	36/164 (22%)
mwh	NP_001261244.1	Drf_FH3	524..725	CDD:283917	41/200 (21%)
Fmnl1	XP_006247560.1	Drf_GBD	28..286	CDD:283920	59/311 (19%)
		Drf_FH3	289..469	CDD:283917	40/188 (21%)
		FH2	635..1000	CDD:280362	10/67 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1923
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45857
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910