Protein Alignment mwh and Fmnl3

DIOPT Version :9

• Sequence 1: NP_001261244.1
• Gene: mwh / 38131
• FlyBaseID: FBgn0264272
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_035841.1
• Gene: Fmnl3 / 22379
• MGIID: 109569
• Length: 1028
• Species: Mus musculus
• Alignment Length: 597
• Identity: 117/597 - (19%)
• Similarity: 206/597 - (34%)
• Gaps: 185/597 - (30%)

  Fly   236 PSVCEMAGQG----QSGPVPPQKASGSNSSKGTNKCGASSLNGSLASYKIGGSEQSWPQAPVYSK 296
            |..||:..:.    .|..:||.||.                  .|..|   .:|:.|.    ...
Mouse    29 PEPCELEERFALVLSSMNLPPDKAR------------------LLRQY---DNEKKWD----LIC 68

  Fly   297 ENQRPPVYN-PEDYVHSLRKFIKASGSAKKLSIYDVFTGPSPKEEASRSATLPAKHSEYKSPIPA 360
            :.:|..|.| |..|:..|:.|:..:.:.||..
Mouse    69 DQERFQVKNPPHTYIQKLQSFLDPNVTRKKFR--------------------------------- 100

  Fly   361 PPENDREMSLRQFGSITDLLTKLRADLRVSFPSFVQEFVGTPADGISHLLEVL------------ 413
                      |:....|.:|.:|...||.:...:|:||:.....|:..|::.|
Mouse   101 ----------RRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFE 155

  Fly   414 -----------------RAIQMAQASNA-PAPMPGASSSLAMNRNPQSYQ------RRALL---- 450
                             |:|:..|..|| .||.   ::|||.:......:      ||||.
Mouse   156 GLESGDDGAFDKLRSWSRSIEDLQPPNALSAPF---TNSLARSARQSVLRYSTLPGRRALKNSRL 217

  Fly   451 -----DELSCLQCLSICCSRSLDAIARLGNTPVGLMPLASSATGQGIRARILALQLLASACDRQP 510
                 |...|:.||....:... ....:.:.|..:..:|.|...:..|.:.|.|:|||:.|
Mouse   218 VSQKDDVHVCILCLRAIMNYQY-GFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVC---- 277

  Fly   511 FGSGSGGQKIASAGHTAVSDAMSTLRLRCSEPVRFRLLVGILNSGGGSGELQCAGVKFLNTFIES 575
                     :...||..:..|....:..|.|..||..|:....:...:.:...|.::|:|..:.|
Mouse   278 ---------LVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHS 333

  Fly   576 AVSIQQRLYIQAELFQAGLDASTLARTISSSSPWLDALKIEVKRFNELHIDVDQMITRARDAERV 640
            ...:..|:::|.|..:.||: ..|.::..:.|   :.|:::::.:.:...||..::   .|||
Mouse   334 VEDMNFRVHLQYEFTKLGLE-EFLQKSRHTES---EKLQVQIQAYLDNVFDVGGLL---EDAE-- 389

  Fly   641 RSQMVILERRVQILHEEKAVLT----SMERRLQERCAELQREIFRLQGTQQQSKFKPVESSHQPV 701
             ::.|.|| :|:.|.|..:.||    .:|.....|.|||::::.:.:...:..|.....:|:|..
Mouse   390 -TKNVALE-KVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSNQVH 452

  Fly   702 ALPRQVPPPKKNKQNSSEHE--------------------------DEGISSSETGASLSPVP-- 738
            .|.|.:    |.|:.:.:..                          .|||..|:... |:|.|
Mouse   453 TLRRLI----KEKEEAFQRRCHLEPSARGLESMGGEALARVGPTELTEGIPPSDLDL-LAPAPPT 512

  Fly   739 --ILILPSKAKP 748
              .|.||....|
Mouse   513 EETLPLPPPPAP 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mwh	NP_001261244.1	Drf_GBD	<380..506	CDD:283920	37/170 (22%)
		Drf_FH3	524..725	CDD:283917	46/230 (20%)
Fmnl3	NP_035841.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		Drf_GBD	26..278	CDD:283920	61/333 (18%)
		Drf_FH3	281..472	CDD:283917	45/205 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	493..541		11/33 (33%)
		FH2	561..926	CDD:280362

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1923
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45857
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870