Protein Alignment mwh and fozi-1

DIOPT Version :10

• Sequence 1: NP_001261244.1
• Gene: mwh / 38131
• FlyBaseID: FBgn0264272
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_001379050.1
• Gene: fozi-1 / 176308
• WormBaseID: WBGene00010453
• Length: 732
• Species: Caenorhabditis elegans
• Alignment Length: 767
• Identity: 135/767 - (17%)
• Similarity: 249/767 - (32%)
• Gaps: 271/767 - (35%)

  Fly   199 MFEAGKSMVDSDSSTLQRHHPQPRHPGQLGQLHLEMAPSVCEMAGQGQSGPVPPQKASGSNSSKG 263
            :|:|.::||        :.|.|.:...|:.|...:...       |.|....|.|..|.|:..|.
 Worm    93 LFQAQQAMV--------QFHNQQKQQQQIIQQQQQQQQ-------QQQQNQNPSQSQSSSSDRKR 142

  Fly   264 TNKCG-------ASSLNGSLASYKIGGSEQSWP--QAP------VYSKENQR-----------PP 302
            :..|.       ...::.|.....|.....:.|  |.|      .|||.|.:           .|
 Worm   143 SYPCTFQYCVICQKDVHSSKLPCHIRQCHVAKPMFQCPACDFTSTYSKNNVKSHMVSLHGLAGDP 207

  Fly   303 VYNPEDYVHSLRKFIK-----ASGSAKKLSIYDVFTGPSPKEEASRSATLPAKHSEYKSPIPA-- 360
            :...:.|...:.:|:|     ..|..:.:.     ...|||  :..|.|.|.:.....|.:|:
 Worm   208 ISYMDKYAGQVEEFMKLCFPNVRGRGRPMQ-----GRSSPK--SPTSPTQPGRRGSQASSLPSRR 265

  Fly   361 --PPENDREMSLRQFGSITDLLTKLRADLRVS-----FPSFV---------------------QE 397
              ..:||...:|:|..........|| :||.:     ||:.:                     ||
 Worm   266 NTVSQNDLLATLQQHQQQQAAFHPLR-NLRFNPLQSIFPAVLANNNNNSVLATNKHVNNFLIKQE 329

  Fly   398 FVGTPADGISHLLEVLRAIQMAQASNAPAPMPGASSSLAM-------NRNPQSYQRR---ALLDE 452
            ....|.  |:..::.|:.  |..|:::|:|:..:||.:.:       |..|: |.:.   .:|::
 Worm   330 ESEVPP--ITMPMQDLKT--MLDANSSPSPISLSSSIIPIQPIKPGENAQPK-YMKSLDWTILND 389

  Fly   453 LSCLQCLSICCSRSLDAIARLGNTPVGLMPLASSATGQGIRARILALQLLASACDRQPFGSGSGG 517
            |.....:...|..:::..|                  :.|..:|...:...|
 Worm   390 LQMKGTVFADCRSNMELYA------------------ENIARKIENTKAFQS------------- 423

  Fly   518 QKIASAGHTAVSDAMSTLRLRCSEPVRFRLLVGILNSGGGSGELQCA----GVKFLN-TFIESAV 577
                    ..:||.|.|:    .|.||.|:.:.:.       |:..|    .:|.|| ..::|.:
 Worm   424 --------FVLSDDMRTV----VEEVRSRVSIQLF-------EVMFAIHRMDIKVLNQNLVDSLL 469

  Fly   578 SIQQRLYIQAELFQAGLDASTLARTISSSSP----WLDALKIEVKRFNELHID-----VDQMITR 633
            .|.          ....||..|.:..:.|.|    .|...||:       ||:     :..|...
 Worm   470 QIA----------PTNSDAQLLRKMENLSDPNEEFLLGLTKID-------HIEEKLETMKHMYRF 517

  Fly   634 ARDAERVRSQMVILERRVQILHEEKAVLTSMERRLQERCAEL------QREIFRLQGTQQQSKFK 692
            ....|.::..::..|..|::|.|.:|:...|:..|    |.|      .|:...:.|. ..|...
 Worm   518 PEQVELLKENIIKYEIAVKVLSESRALRNVMQLVL----AILNIGFFDDRQCLSINGF-SVSDIS 577

  Fly   693 PVESSHQPVALPRQVPPPKKNKQNSSEHEDEGISSSETGASLSPVPILILPSKAKPSRKVVEEDE 757
            .:.|::.|                             :|.|:..:.:.||..:       :..|.
 Worm   578 SILSTNTP-----------------------------SGQSVQSILVTILKDE-------INLDL 606

  Fly   758 DDAATIEDVIEELDN-----------IVSE----AEKQISSQTS------------SVTRPKMRH 795
            |:...:.||:|:::|           ::.:    |||::....|            ::::.:..|
 Worm   607 DELFGLIDVLEKIENDDVNSVAQDLMVLDDKTVRAEKEMEHSGSNIPLSEFVENAKTISKERWEH 671

  Fly   796 HRPVEKEIVPVNIV---PQPPRKS--------------RSLAHLVPRTDCSD 830
            .:.::..|..:.|.   |.|..::              |||...:...|.||
 Worm   672 FKSLKTSIERLTIYLGSPLPRHQNLDAHSPFNNVLQMLRSLKTAIELDDASD 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mwh	NP_001261244.1	Drf_GBD	<349..506	CDD:461886	33/196 (17%)
		Drf_FH3	524..725	CDD:461885	41/220 (19%)
fozi-1	NP_001379050.1	FH2	370..726	CDD:214697	76/463 (16%)