Protein Alignment mwh and frl-1

DIOPT Version :10

• Sequence 1: NP_001261244.1
• Gene: mwh / 38131
• FlyBaseID: FBgn0264272
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_497505.4
• Gene: frl-1 / 175346
• WormBaseID: WBGene00021698
• Length: 1200
• Species: Caenorhabditis elegans
• Alignment Length: 1218
• Identity: 212/1218 - (17%)
• Similarity: 362/1218 - (29%)
• Gaps: 486/1218 - (39%)

  Fly   250 VPPQK-----ASGSNSSKGTNKCGASSLNGSLASYKIGGSEQS--------WPQ-APVYSKENQR 300
            |.|:|     ...:||.:.:|     |.:..:.|.:|....||        .|. ||....:.|.
 Worm    43 VKPKKKKEDPGGSANSLRRSN-----STSSDIRSRRISSVIQSRECSTMIVGPTVAPPMPPQEQL 102

  Fly   301 PPVYN--------PEDYVHSLRKFIKASGSAKKLSIYDVFTGPSPKEEASRSATLPAKHSEYKSP 357
            ..:::        |.|.:..||.:   ....|...|.|        ::.::..|.|||:.|..|.
 Worm   103 DKMFDDVLKHMDLPVDKLRILRGY---DNDKKWKLIVD--------QQVAKQVTPPAKYLEKLSY 156

  Fly   358 IPAPPENDREMSLRQFG---SITDLLTKLRADLRVSFPSFVQEFVGTPADGISHLLEVLRAIQMA 419
            ........:.:..::.|   :.|.:|..:...||.:...:|.||:.||..|:..|::.:|.:...
 Worm   157 FLDKKLLKKALKNKEIGVDETSTSVLRHIEISLRTNSVDWVFEFLNTPNLGLRKLVDYMRTLLAD 221

  Fly   420 QASNAPAPMPG---------ASSSLAMNRNPQSYQR----------------------------- 446
            .|.:.|:...|         |:||:..|.|..|...
 Worm   222 CAPSVPSTSSGLPAGFLNSTANSSVGANNNHSSLNESPSHNSSYEMSTTTTANTSNSFDATANLL 286

  Fly   447 -----------------RALLDELSCLQCLSICCSRSLDAIARLGNTPVGLMPLASSATGQGIRA 494
                             .|:.|...|:.||....:..........:|. .:..:..|...|.:|.
 Worm   287 KKGPLTISKGKVAKTTGEAVDDIHICMMCLRAIMNNKQGFQQVFADTD-AIYCIVRSILHQNLRT 350

  Fly   495 RILALQLLASACDRQPFGSGSGGQKIASAGHTAVSDAMSTLRLRCSEPVRF-RLLVGILNSGGGS 558
            :.|.||:|:|.|..|      |||::       ||||.........||.|| .|:..:.:.....
 Worm   351 KTLVLQMLSSICWVQ------GGQEL-------VSDAFDRFEKDFREPRRFWTLMQFVSHPPEFH 402

  Fly   559 GELQCAGVKFLNTFIESAVSIQQRLYIQAELFQAGLD--ASTLARTISSSSPWLDALKIEVKRFN 621
            .|...:.|:|...|: :...:..|:::|.|:...|||  ...:|...|      |.|:..:..:.
 Worm   403 VEFLSSAVQFFYYFV-NVDDLNFRVHLQYEMTLLGLDKYIDMMAECES------DELQERMISYQ 460

  Fly   622 ELHIDVDQMITRAR-------DAERVRSQMVILERRVQILH------------------------ 655
            ...|||.|::..:.       :.||:.||:...:.|:|.:.
 Worm   461 NNGIDVQQLLDDSNQKTELLDENERILSQLSQAKERIQEVEAKWITDKAALDRRLFDLVKERESM 525

  Fly   656 -----EEKA----VLTSMERRLQERCAELQREIFRLQGTQQQSKF-KPVESSHQPVAL------- 703
                 |||.    .:...:|:.:|....|:::|..|:..|:|.:. ..|:...|..|.
 Worm   526 EKEYVEEKGSWTKTMNEKDRQAREERKRLEQKIGELEAIQKQMQAGLQVQQQQQAAAAAAAAAAQ 590

  Fly   704 --PRQVPPP-----KKNKQNSSEHEDEG-----------------ISSSETGASLSPVPILILPS 744
              |...|||     |:.::::|:.....                 ::::.|...:.|.|...||.
 Worm   591 KSPPTPPPPAPGPHKEQRRSTSKDPPRPAPPPVSSIPPPPPIAGLLAANGTNVPIPPPPPPPLPQ 655

  Fly   745 KAK---------------------PSRKVVEEDEDDAATI------------------------- 763
            ...                     |...::....:||.||
 Worm   656 NLSGAPPPPPPPPPMLGGPPPPPPPPGGLMGPASNDAKTIKKIYQTKNKLPQLNWTAMKPMQAKN 720

  Fly   764 --------EDVIEELDNIVSE----------------AEKQISSQTS------------------ 786
                    |.:||:||....|                :|:.:..|.|
 Worm   721 TVFEKLNDELIIEKLDFSKLEEMFKLAQPTLGLAEPKSEQSVIGQVSPGSTTSAAGTSSARKNTL 785

  Fly   787 ---------SVTRPKMRH---------HR------PVEKEIVPVNIVP----------------- 810
                     ::||.|:..         |:      ..||..:...|:|
 Worm   786 LDTKRLQNVAITRRKVAMDAKSIMAAVHQLNLSALSAEKVDILSRILPTDEERKLYAGKKTTESE 850

  Fly   811 -----------------QPPRKSRSLA--------------------HLVPRTDC---------- 828
                             :..|....||                    |:...:.|
 Worm   851 NSMENLSEDDNFVAALCEIERLEHKLAVMRVMSEFDESAGLLEPQFTHVTAASKCAREAQLFHGV 915

  Fly   829 ------------SDQEGSDYGM---------VLHQPAD----------PDAAERLAAMQSFFDE- 861
                        |.:.|..||.         :|..|||          .:..:.|..:::|.::
 Worm   916 LEVILAFGNYMNSGKRGGAYGFKLSSLDSLAILKAPADRSLTLLHMIVAEIEKNLPHLKTFSEQL 980

  Fly   862 --------VDYDAPETDQ---PAAYQM-----ESPTPDMPEANATATAYNASTNRELLDVIMNAR 910
                    |.:|:.:||.   .|.::|     |....|.|||.:|   :.||..:::.|:
 Worm   981 KFVDKATSVQWDSVQTDMKELAAGFKMAEKEQELKGTDCPEALST---FTASRKQKMADL----- 1037

  Fly   911 HDDHDPTMQALRKSVQDAAPVTIPHHPVKVKAPAPPPPTPPAQQFNGVFFMTGMNTPQKYPK--- 972
                :...|....|.:|..    ..:....|:.:|.           |||....:..|.|.|
 Worm  1038 ----EQAFQLAASSFKDCC----EFYGENEKSTSPT-----------VFFQKLAHFVQNYQKCRG 1083

  Fly   973 -PDISAALQARRVTKNVERLEAAFASAHPEALNEAAIGREK-SRSNQQIYFTSNLAMRM------ 1029
             .:..|||:.||               ..||...|.:...| |.|::|......||.::
 Worm  1084 ENEAKAALEKRR---------------QEEAERRARVASTKSSASSEQDQLMMELAEKVGGMGIG 1133

  Fly  1030 -----------HDHSGFANSSGGQIQGPTLRTRSHTQGSMSKVTDLPS 1066
                       .||..|.....|      |:....|..:..|::..||
 Worm  1134 KRPRGKIDSTRMDHGDFEKLMNG------LKHTGGTTPNRRKMSKSPS 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mwh	NP_001261244.1	Drf_GBD	<349..506	CDD:461886	40/214 (19%)
		Drf_FH3	524..725	CDD:461885	52/275 (19%)
frl-1	NP_497505.4	Drf_GBD	94..362	CDD:461886	51/279 (18%)
		Drf_FH3	366..561	CDD:461885	43/208 (21%)
		FH2	695..1079	CDD:396655	57/410 (14%)