DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mwh and FMNL2

DIOPT Version :9

Sequence 1:	NP_001261244.1	Gene:	mwh / 38131	FlyBaseID:	FBgn0264272	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_011508832.1	Gene:	FMNL2 / 114793	HGNCID:	18267	Length:	1099	Species:	Homo sapiens

Alignment Length:	816	Identity:	150/816 - (18%)
Similarity:	251/816 - (30%)	Gaps:	311/816 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 MFEAGKSMVDSDSSTLQRHH-----PQPRHPGQLGQLHLEMAPSVCEMAGQGQSGPVPPQKASGS 258
            |..||.  :||..:..:.|:     |.| .||:|.:....:..::          .:||.||.
Human     1 MGNAGS--MDSQQTDFRAHNVPLKLPMP-EPGELEERFAIVLNAM----------NLPPDKAR-- 50

  Fly   259 NSSKGTNKCGASSLNGSLASYKIGGSEQSWPQAPVYSKENQRPPVYN-PEDYVHSLRKFIKASGS 322
                            .|..|   .:|:.|.    ...:.:|..|.| |..|:..|:.::..:.:
Human    51 ----------------LLRQY---DNEKKWE----LICDQERFQVKNPPHTYIQKLKGYLDPAVT 92

  Fly   323 AKKLSIYDVFTGPSPKEEASRSATLPAKHSEYKSPIPAPPENDREMSLRQFGSITDLLTKLRADL 387
            .||..                                           |:....|.:|.:|...|
Human    93 RKKFR-------------------------------------------RRVQESTQVLRELEISL 114

  Fly   388 RVSFPSFVQEFVGTPADGISHLLEVLRAIQMA------------------------------QAS 422
            |.:...:|:||:.....|:..|:|.|...|.|                              :.|
Human   115 RTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGS 179

  Fly   423 NAPAPM------PGASSSLAMNRNPQSYQRRALL---------DELSCLQCLSICCSRSLDAIAR 472
            |.|:|:      .|..|:|..|..|   .||.|.         |...|:.||....:... ....
Human   180 NLPSPVGNSVSRSGRHSALRYNTLP---SRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQY-GFNM 240

  Fly   473 LGNTPVGLMPLASSATGQGIRARILALQLLASACDRQPFGSGSGGQKIASAGHTAVSDAMSTLRL 537
            :.:.|..:..:|.|...:..|.:.|.|:|||:.|             :...||..:..|....:.
Human   241 VMSHPHAVNEIALSLNNKNPRTKALVLELLAAVC-------------LVRGGHEIILSAFDNFKE 292

  Fly   538 RCSEPVRFRLLVGILNSGGGSGELQCAGVKFLNTFIESAVSIQQRLYIQAELFQAGLD--ASTLA 600
            .|.|..||..|:....:...:.:...|.::|:|..:.|...:..|:::|.|..:.|||  ...|.
Human   293 VCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLK 357

  Fly   601 RTISSSSPWLDALKIEVKRFNELHIDVDQMITRARDAERVRSQMVILERRVQIL--------HEE 657
            .|.|      |.|:::::.:.:...||..::..|........::..||..:..|        :|.
Human   358 HTES------DKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEA 416

  Fly   658 KAVLTSMERRLQERCAELQ--REIFRLQGTQQQSKFKPVESSHQPVALPRQVPPPKKNKQNSSEH 720
            .:.:..:|::|.:|..||.  |||::...||..:..|.|:...:  |:.||....||    ..|.
Human   417 MSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEE--AIQRQSTLEKK----IHEL 475

  Fly   721 EDEGISSSETGASLSPVPILILPSKAKPSRKVVEEDEDDAATIEDVIEELDNIVSEAEKQISSQT 785
            |.:|                        :.|:.::.:.|.|.:               ..::|.|
Human   476 EKQG------------------------TIKIQKKGDGDIAIL---------------PVVASGT 501

  Fly   786 SSVTRPKMRHHRPVEKEIVPVNIVPQPPRKSRSLAHLVPRTDCSDQEGSDYGMVLHQPADPDAAE 850
            .|           :..|:|..|.|                       |...|.....|..|
Human   502 LS-----------MGSEVVAGNSV-----------------------GPTMGAASSGPLPP---- 528

  Fly   851 RLAAMQSFFDEVDYDAPETDQPAAYQMESPTPDMPEANATATAYNASTNRELLDVIMNARHDDHD 915
                                         |.|.:|.::.|.
Human   529 -----------------------------PPPPLPPSSDTP------------------------ 540

  Fly   916 PTMQALRKSVQDAAPVTIPHHPVKVKAPAPPPPTPP 951
                   ::||: .|||.|..|.....|.||||.||
Human   541 -------ETVQN-GPVTPPMPPPPPPPPPPPPPPPP 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mwh	NP_001261244.1	Drf_GBD	<380..506	CDD:283920	38/170 (22%)
mwh	NP_001261244.1	Drf_FH3	524..725	CDD:283917	49/212 (23%)
FMNL2	XP_011508832.1	Drf_GBD	23..275	CDD:283920	62/347 (18%)
		Drf_FH3	278..475	CDD:283917	47/208 (23%)
		FH2	623..974	CDD:280362
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1923
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45857
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.870