DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trh and TPH1

DIOPT Version :9

Sequence 1:	NP_612080.1	Gene:	Trh / 38121	FlyBaseID:	FBgn0035187	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_004170.1	Gene:	TPH1 / 7166	HGNCID:	12008	Length:	444	Species:	Homo sapiens

Alignment Length:	452	Identity:	260/452 - (57%)
Similarity:	345/452 - (76%)	Gaps:	24/452 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 QDN--GRQHS-PGERISIIFTLRNQVGNLARALQVFQELGINVLHLELSPLEMATNQADVLVDVE 128
            :||  .:.|| ...|.|:||:|:|:||.|.:||::|||..:|:||:|....:...::.::.||.:
Human     3 EDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCD 67

  Fly   129 CDQRRLDQVVKML--NREVASVNYT---SVNTQGLARAPSLSACSSFDFGDMVWFPRKISDLDKA 188
            .::.:|:.:..:|  :..|.|||..   ::...|:...|              |||:||||||..
Human    68 INREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVP--------------WFPKKISDLDHC 118

  Fly   189 QN-VLMYGSELDADHPGFKDPVYRKRREQFSAIANNFKHGNPIPRVQYTPEEVKTWGTVFLELHR 252
            .| |||||||||||||||||.||||||:.|:.:|.|:|||:|||:|::|.||:|||||||.||::
Human   119 ANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNK 183

  Fly   253 LYVLHAVPEYMDNWPELEKYCGYREDNVPQLQDVSVYLKRKTGFQLRPVAGYLSPRDFLSGLAFR 317
            ||..||..||:.|.|.|.|||||||||:|||:|||.:||.:|||.:|||||||||||||||||||
Human   184 LYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFR 248

  Fly   318 VFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANSSFAQFSQEIGLASLGASDADIEKLATLYF 382
            |||||||:|||||||||||||.|||||||:||||..|||||||||||||||||:..::||||.||
Human   249 VFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYF 313

  Fly   383 FTVEFGLCKQADSTFKVYGAGLLSSVAELQHAITAENKIKKFDPEVTCQQECIITSYQNAYYYTD 447
            |||||||||| |...:|:|||||||::||:||::...|:|.|||::||:|||:||::|:.|:.::
Human   314 FTVEFGLCKQ-DGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSE 377

  Fly   448 SFEEAKEQMRAFAESIQRPFGVRYNPYTMSVEVLSNAKKITAVVSELRGDLSIVCSALRKIS 509
            |||:|||:||.|.::|:|||||:|||||.|:::|.:.|.||:.::||:.||.:|..||.|:|
Human   378 SFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVS 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trh	NP_612080.1	Trp_5_monoox	34..509	CDD:130337	259/450 (58%)
		ACT_TPH	79..152	CDD:153201	25/77 (32%)
		Biopterin_H	177..506	CDD:278766	225/329 (68%)
TPH1	NP_004170.1	Trp_5_monoox	3..439	CDD:130337	259/450 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147585
Domainoid	1	1.000	492	1.000	Domainoid score	I366
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121565
Inparanoid	1	1.050	537	1.000	Inparanoid score	I1200
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54212
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	1	1.000	-	-		otm40657
orthoMCL	1	0.900	-	-		OOG6_100921
Panther	1	1.100	-	-	O	PTHR11473
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3230
SonicParanoid	1	1.000	-	-		X2372
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.940