DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trh and TH

DIOPT Version :9

Sequence 1:	NP_612080.1	Gene:	Trh / 38121	FlyBaseID:	FBgn0035187	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_954986.2	Gene:	TH / 7054	HGNCID:	11782	Length:	528	Species:	Homo sapiens

Alignment Length:	470	Identity:	212/470 - (45%)
Similarity:	302/470 - (64%)	Gaps:	43/470 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 ASAPPEP--PRLAIGGGGQDNGRQHSPGERI-SIIFTLR-NQVGNLARALQVFQELGINVLHLEL 111
            |:.|.||  |..|:       ..:...|:.: :::|:.| .:...|:||::||:.....:.|||.
Human    89 AAVPSEPGDPLEAV-------AFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIHHLET 146

  Fly   112 SPLEMATNQADVL-VDVECDQRRLDQV-----VKMLNREVASVNYTSVNTQGLARAPSLSACSSF 170
            .|.:........| ..|..:.||.|..     |:.::.:|              |:|:
Human   147 RPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDV--------------RSPA------- 190

  Fly   171 DFGDMV-WFPRKISDLDKAQN-VLMYGSELDADHPGFKDPVYRKRREQFSAIANNFKHGNPIPRV 233
              |..| |||||:|:|||..: |..:..:||.|||||.|.|||:||:..:.||..::||:|||||
Human   191 --GPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRV 253

  Fly   234 QYTPEEVKTWGTVFLELHRLYVLHAVPEYMDNWPELEKYCGYREDNVPQLQDVSVYLKRKTGFQL 298
            :||.||:.||..|:..|..||..||..|:::.:..||::.||||||:|||:|||.:||.:|||||
Human   254 EYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQL 318

  Fly   299 RPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANSSFAQFSQEIG 363
            |||||.||.||||:.||||||.|||||||:|.|.::||||||||||||:|:||:.:||||||:||
Human   319 RPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIG 383

  Fly   364 LASLGASDADIEKLATLYFFTVEFGLCKQADSTFKVYGAGLLSSVAELQHAITAENKIKKFDPEV 428
            ||||||||.:||||:|||:|||||||||| :...|.||||||||..||.|.::.|.:|:.||||.
Human   384 LASLGASDEEIEKLSTLYWFTVEFGLCKQ-NGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEA 447

  Fly   429 TCQQECIITSYQNAYYYTDSFEEAKEQMRAFAESIQRPFGVRYNPYTMSVEVLSNAKKITAVVSE 493
            ...|.....:||:.|:.::||.:||:::|::|..|||||.|:::|||::::||.:.:.:...:..
Human   448 AAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEG 512

  Fly   494 LRGDLSIVCSALRKI 508
            ::.:|..:..||..|
Human   513 VQDELDTLAHALSAI 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trh	NP_612080.1	Trp_5_monoox	34..509	CDD:130337	212/470 (45%)
		ACT_TPH	79..152	CDD:153201	18/80 (23%)
		Biopterin_H	177..506	CDD:278766	181/329 (55%)
TH	NP_954986.2	TOH_N	2..26	CDD:289326
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..65
		TOH_N	37..61	CDD:289326
		Tyr_3_monoox	69..525	CDD:130336	210/466 (45%)
		ACT_TH	69..190	CDD:153202	26/121 (21%)
		Biopterin_H	195..525	CDD:278766	181/330 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820