DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trh and tph1b

DIOPT Version :9

Sequence 1:	NP_612080.1	Gene:	Trh / 38121	FlyBaseID:	FBgn0035187	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001001843.2	Gene:	tph1b / 415103	ZFINID:	ZDB-GENE-030805-6	Length:	480	Species:	Danio rerio

Alignment Length:	437	Identity:	252/437 - (57%)
Similarity:	333/437 - (76%)	Gaps:	11/437 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 SPGERISIIFTLRNQVGNLARALQVFQELGINVLHLELSPLEMATNQADVLVDVECDQRRLDQVV 138
            |..|..:|:|:|:|:||.|.:||::||:..:|:||:|........::.:||||.:.|:..|.::|
Zfish    49 SKREHAAIVFSLKNEVGGLVKALKLFQDNQVNLLHIESRKSRRRNSELEVLVDCDSDRETLKEIV 113

  Fly   139 KMLNREVASVNYTSVNTQGLARAPSLSACSSFDFGDMVWFPRKISDLDK-AQNVLMYGSELDADH 202
            ::|.::.:.:...|         |......:.|..::.|||:||||||| |..||||||||||||
Zfish   114 QLLRKQTSIIAMNS---------PDKFWTPASDLTEVPWFPKKISDLDKSACRVLMYGSELDADH 169

  Fly   203 PGFKDPVYRKRREQFSAIANNFKHGNPIPRVQYTPEEVKTWGTVFLELHRLYVLHAVPEYMDNWP 267
            |||||.||||||:.|:.:|.::|||:|||.|::|.|||||||.||.||::||..||..||:.|.|
Zfish   170 PGFKDNVYRKRRKYFADLAMSYKHGDPIPHVEFTEEEVKTWGVVFRELNKLYPTHACREYLQNLP 234

  Fly   268 ELEKYCGYREDNVPQLQDVSVYLKRKTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPF 332
            .|.::|||||||:|||:|||.:|:.:|||.:|||||||||||||:||||||||||||:||||||.
Zfish   235 LLSQFCGYREDNIPQLEDVSNFLRERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPL 299

  Fly   333 YTPEPDCCHELLGHMPLLANSSFAQFSQEIGLASLGASDADIEKLATLYFFTVEFGLCKQADSTF 397
            ||||||.|||||||:||||..||||||||:|||||||||..::||||.|||||||||||| :.:.
Zfish   300 YTPEPDTCHELLGHVPLLAEPSFAQFSQELGLASLGASDDAVQKLATCYFFTVEFGLCKQ-EGSL 363

  Fly   398 KVYGAGLLSSVAELQHAITAENKIKKFDPEVTCQQECIITSYQNAYYYTDSFEEAKEQMRAFAES 462
            :.||||||||::||:|:::...||..|:|:|||:|||:||::|:.|:.::||||||.:||.||::
Zfish   364 RAYGAGLLSSISELKHSLSDSAKILPFEPKVTCKQECLITTFQDVYFVSESFEEAKCRMREFAKT 428

  Fly   463 IQRPFGVRYNPYTMSVEVLSNAKKITAVVSELRGDLSIVCSALRKIS 509
            |||||.:||||||.||.||.:...|..||.|||.:|.||..||.::|
Zfish   429 IQRPFSLRYNPYTQSVCVLKDMPSINDVVEELRHELDIVGDALCRLS 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trh	NP_612080.1	Trp_5_monoox	34..509	CDD:130337	251/435 (58%)
		ACT_TPH	79..152	CDD:153201	23/72 (32%)
		Biopterin_H	177..506	CDD:278766	222/329 (67%)
tph1b	NP_001001843.2	Trp_5_monoox	52..475	CDD:130337	250/432 (58%)
		ACT_TPH	54..127	CDD:153201	23/72 (32%)
		Biopterin_H	142..471	CDD:278766	221/329 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581371
Domainoid	1	1.000	472	1.000	Domainoid score	I424
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121565
Inparanoid	1	1.050	520	1.000	Inparanoid score	I1225
OMA	1	1.010	-	-		QHG54212
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	1	1.000	-	-		otm24815
orthoMCL	1	0.900	-	-		OOG6_100921
Panther	1	1.100	-	-	O	PTHR11473
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3230
SonicParanoid	1	1.000	-	-		X2372
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800