DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Trh and tph2

DIOPT Version :9

Sequence 1:NP_612080.1 Gene:Trh / 38121 FlyBaseID:FBgn0035187 Length:555 Species:Drosophila melanogaster
Sequence 2:NP_001296997.1 Gene:tph2 / 407712 ZFINID:ZDB-GENE-040624-4 Length:546 Species:Danio rerio


Alignment Length:526 Identity:263/526 - (50%)
Similarity:357/526 - (67%) Gaps:36/526 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 KSLLGLWLYRSGEQE---------------WAVKQGSPLHQLKKDSTTSGSS--SHPSLGRNASA 53
            ||.:|| |.:.|::.               || ::|..|.....|.....||  ...|..|....
Zfish    30 KSPVGL-LRKRGQEAIPKMQPAMMMFSSKYWA-RRGLSLDSAMYDQQHLASSMLRRTSFNRIDER 92

  Fly    54 PPEPPRLAIGGGGQDNGRQHSPGERISIIFTLRNQVGNLARALQVFQELGINVLHLELSPLEMAT 118
            |.:          ::....|..| ::::||:|:|:||.|.:||::|||..:|:.|:|....:..|
Zfish    93 PDK----------EEQKSTHDLG-KLAVIFSLKNEVGFLVKALRLFQEKHVNLAHIESRRSKRLT 146

  Fly   119 NQADVLVDVECDQRRLDQVVKMLNREVASVNYTSVNTQGLARAPSLSACSSF----DFGDMVWFP 179
            |:.::..:..|.::..:::|:.|...|..|:|.:......|....|......    |...:.|||
Zfish   147 NEIEIYAECNCTKKEFNELVQHLKDHVNIVSYNTPQHVWSAETDCLDCVCVLGGLPDGEGIPWFP 211

  Fly   180 RKISDLDK-AQNVLMYGSELDADHPGFKDPVYRKRREQFSAIANNFKHGNPIPRVQYTPEEVKTW 243
            :|||:||: :..|||||||||||||||||.|||:||:.|..:|.|:|.|.||||::||.||||||
Zfish   212 QKISELDQCSHRVLMYGSELDADHPGFKDKVYRQRRKYFVEVAMNYKFGQPIPRIEYTAEEVKTW 276

  Fly   244 GTVFLELHRLYVLHAVPEYMDNWPELEKYCGYREDNVPQLQDVSVYLKRKTGFQLRPVAGYLSPR 308
            |.|:.||.:||..||..||:.|.|.|.|:|||||||:|||:|||::|:.::||.:||||||||||
Zfish   277 GVVYRELTKLYPTHACREYLKNLPLLTKHCGYREDNIPQLEDVSLFLRERSGFTVRPVAGYLSPR 341

  Fly   309 DFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANSSFAQFSQEIGLASLGASDAD 373
            |||:|||:|||:||||||||:||.||||||.|||||||:||||:..|||||||||||||||||.|
Zfish   342 DFLAGLAYRVFNCTQYIRHSTDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDED 406

  Fly   374 IEKLATLYFFTVEFGLCKQADSTFKVYGAGLLSSVAELQHAITAENKIKKFDPEVTCQQECIITS 438
            ::||||.||||:||||||| |...:|||||||||:.||:||::.:..:|.|||:.||.|||:||:
Zfish   407 VQKLATCYFFTIEFGLCKQ-DGQLRVYGAGLLSSIGELRHALSDKATVKVFDPKTTCYQECLITT 470

  Fly   439 YQNAYYYTDSFEEAKEQMRAFAESIQRPFGVRYNPYTMSVEVLSNAKKITAVVSELRGDLSIVCS 503
            :|:.|:.::|||||||:||.||:||:|||.|.|||||.|:::|.:.:.|..||.:||.||:.||.
Zfish   471 FQDVYFVSESFEEAKEKMREFAKSIKRPFSVYYNPYTQSIDLLKDTRSIENVVQDLRSDLTTVCD 535

  Fly   504 ALRKIS 509
            ||.|::
Zfish   536 ALGKMN 541

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrhNP_612080.1 Trp_5_monoox 34..509 CDD:130337 253/481 (53%)
ACT_TPH 79..152 CDD:153201 23/72 (32%)
Biopterin_H 177..506 CDD:278766 217/329 (66%)
tph2NP_001296997.1 Trp_5_monoox 84..541 CDD:130337 250/468 (53%)
ACT_TPH 108..180 CDD:153201 23/71 (32%)
Biopterin_H 208..537 CDD:278766 216/329 (66%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170581369
Domainoid 1 1.000 472 1.000 Domainoid score I424
eggNOG 1 0.900 - - E1_COG3186
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 520 1.000 Inparanoid score I1225
OMA 1 1.010 - - QHG54212
OrthoDB 1 1.010 - - D361696at33208
OrthoFinder 1 1.000 - - FOG0000587
OrthoInspector 1 1.000 - - otm24815
orthoMCL 1 0.900 - - OOG6_100921
Panther 1 1.100 - - LDO PTHR11473
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2372
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1413.770

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