DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trh and Tph2

DIOPT Version :9

Sequence 1:	NP_612080.1	Gene:	Trh / 38121	FlyBaseID:	FBgn0035187	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_776211.1	Gene:	Tph2 / 317675	RGDID:	631332	Length:	485	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	254/470 - (54%)
Similarity:	341/470 - (72%)	Gaps:	23/470 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 SAPPEPPRLAIGGGGQD-----------NGRQHSPGERISIIFTLRNQVGNLARALQVFQELGIN 105
            ||.||..:: :||..|:           :|:..|...:.:::|:|:|:||.|.|||::|||..:|
  Rat    22 SAVPEEHQI-LGGLTQNKATASKSEDKRSGKDTSESSKTAVVFSLKNEVGGLVRALRLFQEKHVN 85

  Fly   106 VLHLELSPLEMATNQADVLVDVECDQRRLDQVVKMLNREVASVNYTSVNTQGLARAPSLSACSSF 170
            :||:|.......:::.::.||.||.:...::::::|..:...|.         ...|........
  Rat    86 MLHIESRRSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVT---------LNPPDNIWTEEE 141

  Fly   171 DFGDMVWFPRKISDLDK-AQNVLMYGSELDADHPGFKDPVYRKRREQFSAIANNFKHGNPIPRVQ 234
            :..|:.|||||||:||: :..|||||:|||||||||||.|||:||:.|..:|..:|:|.|||||:
  Rat   142 ELEDVPWFPRKISELDRCSHRVLMYGTELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVE 206

  Fly   235 YTPEEVKTWGTVFLELHRLYVLHAVPEYMDNWPELEKYCGYREDNVPQLQDVSVYLKRKTGFQLR 299
            ||.||.||||.||.||.:||..||..||:.|:|.|.|||||||||||||:|||::||.::||.:|
  Rat   207 YTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVR 271

  Fly   300 PVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANSSFAQFSQEIGL 364
            ||||||||||||:|||:||||||||:||.|||.||||||.|||||||:||||:..||||||||||
  Rat   272 PVAGYLSPRDFLAGLAYRVFHCTQYVRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGL 336

  Fly   365 ASLGASDADIEKLATLYFFTVEFGLCKQADSTFKVYGAGLLSSVAELQHAITAENKIKKFDPEVT 429
            |||||||.|::||||.||||:||||||| :...:.||||||||:.||:||::.:..:|.|||:.|
  Rat   337 ASLGASDEDVQKLATCYFFTIEFGLCKQ-EGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTT 400

  Fly   430 CQQECIITSYQNAYYYTDSFEEAKEQMRAFAESIQRPFGVRYNPYTMSVEVLSNAKKITAVVSEL 494
            |.|||:||::|:||:.::|||||||:||.||:||.|||.|.:||||.|:|:|.:.:.|..||.:|
  Rat   401 CLQECLITTFQDAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDL 465

  Fly   495 RGDLSIVCSALRKIS 509
            |.||:.||.||.|::
  Rat   466 RSDLNTVCDALNKMN 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trh	NP_612080.1	Trp_5_monoox	34..509	CDD:130337	254/468 (54%)
		ACT_TPH	79..152	CDD:153201	22/72 (31%)
		Biopterin_H	177..506	CDD:278766	219/329 (67%)
Tph2	NP_776211.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..57		5/24 (21%)
		Trp_5_monoox	48..480	CDD:130337	247/441 (56%)
		ACT_TPH	59..132	CDD:153201	22/81 (27%)
		Biopterin_H	147..477	CDD:278766	219/330 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341385
Domainoid	1	1.000	488	1.000	Domainoid score	I366
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	530	1.000	Inparanoid score	I1178
OMA	1	1.010	-	-		QHG54212
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	1	1.000	-	-		otm44796
orthoMCL	1	0.900	-	-		OOG6_100921
Panther	1	1.100	-	-	LDO	PTHR11473
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2372
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770