DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trh and Th

DIOPT Version :9

Sequence 1:	NP_612080.1	Gene:	Trh / 38121	FlyBaseID:	FBgn0035187	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_033403.1	Gene:	Th / 21823	MGIID:	98735	Length:	498	Species:	Mus musculus

Alignment Length:	529	Identity:	220/529 - (41%)
Similarity:	315/529 - (59%)	Gaps:	56/529 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SASGKSLLGLWLYRSGEQEWAVKQG----SP---------LHQLKKDSTTSGSSSHPSLGRNASA 53
            |||.....|   :|....|...||.    ||         :...:|:...:.:::..::   |||
Mouse     5 SASSPQPKG---FRRAVSEQDTKQAEAVTSPRFIGRRQSLIEDARKEREAAAAAAAAAV---ASA 63

  Fly    54 PPEPPRLAIGGGGQDNGRQHSPGERISIIFTLR-NQVGNLARALQVFQELGINVLHLELSPLE-- 115
            .|..|..|:....:|....      ::::|:|| .:..:|:|||:||:.....:.|||..|.:
Mouse    64 EPGNPLEAVVFEERDGNAV------LNLLFSLRGTKPSSLSRALKVFETFEAKIHHLETRPAQRP 122

  Fly   116 -MATNQADVLVDVEC---DQRRLDQVVKMLNREVASVNYTSVNTQGLARAPSLSACSSFDFGDMV 176
             ..:...:..|..|.   |...|...|:.::.:|.|.....|                      .
Mouse   123 LAGSPHLEYFVRFEVPSGDLAALLSSVRRVSDDVRSAREDKV----------------------P 165

  Fly   177 WFPRKISDLDKAQN-VLMYGSELDADHPGFKDPVYRKRREQFSAIANNFKHGNPIPRVQYTPEEV 240
            |||||:|:|||..: |..:..:||.|||||.|..||:||:..:.||..:|.|.|||.|:||.||:
Mouse   166 WFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQAYRQRRKLIAEIAFQYKQGEPIPHVEYTKEEI 230

  Fly   241 KTWGTVFLELHRLYVLHAVPEYMDNWPELEKYCGYREDNVPQLQDVSVYLKRKTGFQLRPVAGYL 305
            .||..|:..|..||..||..|:::.:..||:|||||||::|||:|||.:||.:||||||||||.|
Mouse   231 ATWKEVYATLKGLYATHACREHLEAFQLLERYCGYREDSIPQLEDVSHFLKERTGFQLRPVAGLL 295

  Fly   306 SPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANSSFAQFSQEIGLASLGAS 370
            |.||||:.||||||.|||||||:|.|.::||||||||||||:|:||:.:||||||:|||||||||
Mouse   296 SARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGAS 360

  Fly   371 DADIEKLATLYFFTVEFGLCKQADSTFKVYGAGLLSSVAELQHAITAENKIKKFDPEVTCQQECI 435
            |.:||||:|:|:|||||||||| :...|.||||||||..||.|:::.|.:::.|||:....|...
Mouse   361 DEEIEKLSTVYWFTVEFGLCKQ-NGELKAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQ 424

  Fly   436 ITSYQNAYYYTDSFEEAKEQMRAFAESIQRPFGVRYNPYTMSVEVLSNAKKITAVVSELRGDLSI 500
            ..:||..|:.::||.:||:::|.:|..|||||.|:::|||::::||.:...|...:..::.:|..
Mouse   425 DQTYQPVYFVSESFSDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIRRSLEGVQDELHT 489

  Fly   501 VCSALRKIS 509
            :..||..||
Mouse   490 LTQALSAIS 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trh	NP_612080.1	Trp_5_monoox	34..509	CDD:130337	208/482 (43%)
		ACT_TPH	79..152	CDD:153201	20/79 (25%)
		Biopterin_H	177..506	CDD:278766	178/329 (54%)
Th	NP_033403.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		9/30 (30%)
		TOH_N	2..26	CDD:289326	7/23 (30%)
		Tyr_3_monoox	38..495	CDD:130336	207/488 (42%)
		ACT_TH	38..158	CDD:153202	27/128 (21%)
		Biopterin_H	165..495	CDD:278766	178/330 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820