DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trh and Tph2

DIOPT Version :9

Sequence 1:	NP_612080.1	Gene:	Trh / 38121	FlyBaseID:	FBgn0035187	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_775567.2	Gene:	Tph2 / 216343	MGIID:	2651811	Length:	488	Species:	Mus musculus

Alignment Length:	472	Identity:	255/472 - (54%)
Similarity:	340/472 - (72%)	Gaps:	24/472 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 SAPPEPPRL--------AIGGGGQDNGRQHSPGE-----RISIIFTLRNQVGNLARALQVFQELG 103
            ||.||..:|        ||....:.:|::...|:     :.:::|:|:|:||.|.:||::|||..
Mouse    22 SAVPEDHQLLGSLTQNKAIKSEDKKSGKEPGKGDTTESSKTAVVFSLKNEVGGLVKALRLFQEKH 86

  Fly   104 INVLHLELSPLEMATNQADVLVDVECDQRRLDQVVKMLNREVASVNYTSVNTQGLARAPSLSACS 168
            :|:||:|.......:::.::.||.||.:...::::::|..:...|.         ...|......
Mouse    87 VNMLHIESRRSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVT---------LNPPESIWTE 142

  Fly   169 SFDFGDMVWFPRKISDLDK-AQNVLMYGSELDADHPGFKDPVYRKRREQFSAIANNFKHGNPIPR 232
            ..|..|:.|||||||:||: :..|||||:|||||||||||.|||:||:.|..:|..:|:|.||||
Mouse   143 EEDLEDVPWFPRKISELDRCSHRVLMYGTELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPR 207

  Fly   233 VQYTPEEVKTWGTVFLELHRLYVLHAVPEYMDNWPELEKYCGYREDNVPQLQDVSVYLKRKTGFQ 297
            |:||.||.||||.||.||.:||..||..||:.|.|.|.|||||||||||||:|||::||.::||.
Mouse   208 VEYTEEETKTWGVVFRELSKLYPTHACREYLKNLPLLTKYCGYREDNVPQLEDVSMFLKERSGFT 272

  Fly   298 LRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANSSFAQFSQEI 362
            :|||||||||||||:|||:||||||||:||.|||.||||||.|||||||:||||:..||||||||
Mouse   273 VRPVAGYLSPRDFLAGLAYRVFHCTQYVRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEI 337

  Fly   363 GLASLGASDADIEKLATLYFFTVEFGLCKQADSTFKVYGAGLLSSVAELQHAITAENKIKKFDPE 427
            |||||||||.|::||||.||||:||||||| :...:.||||||||:.||:||::.:..:|.|||:
Mouse   338 GLASLGASDEDVQKLATCYFFTIEFGLCKQ-EGQLRAYGAGLLSSIGELKHALSDKACVKSFDPK 401

  Fly   428 VTCQQECIITSYQNAYYYTDSFEEAKEQMRAFAESIQRPFGVRYNPYTMSVEVLSNAKKITAVVS 492
            .||.|||:||::|:||:.:||||||||:||.||:||.|||.|.:||||.|:|:|.:.:.|..||.
Mouse   402 TTCLQECLITTFQDAYFVSDSFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQ 466

  Fly   493 ELRGDLSIVCSALRKIS 509
            :||.||:.||.||.|::
Mouse   467 DLRSDLNTVCDALNKMN 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trh	NP_612080.1	Trp_5_monoox	34..509	CDD:130337	255/470 (54%)
		ACT_TPH	79..152	CDD:153201	21/72 (29%)
		Biopterin_H	177..506	CDD:278766	220/329 (67%)
Tph2	NP_775567.2	Trp_5_monoox	33..483	CDD:130337	250/459 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..60		4/25 (16%)
		ACT_TPH	62..135	CDD:153201	21/81 (26%)
		Biopterin_H	150..480	CDD:278766	220/330 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837662
Domainoid	1	1.000	487	1.000	Domainoid score	I386
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1239
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54212
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	1	1.000	-	-		otm42731
orthoMCL	1	0.900	-	-		OOG6_100921
Panther	1	1.100	-	-	LDO	PTHR11473
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2372
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770