Protein Alignment Trh and Pah

DIOPT Version :9

• Sequence 1: NP_612080.1
• Gene: Trh / 38121
• FlyBaseID: FBgn0035187
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_032803.2
• Gene: Pah / 18478
• MGIID: 97473
• Length: 453
• Species: Mus musculus
• Alignment Length: 449
• Identity: 234/449 - (52%)
• Similarity: 309/449 - (68%)
• Gaps: 26/449 - (5%)

  Fly    67 QDNGRQHSPGERISIIFTLRNQVGNLARALQVFQELGINVLHLELSPLEMATNQADVLVDVECDQ 131
            :||..|:.   .:|:||:|:.:||.||:.|::|:|..||:.|:|..|..:..::.:....:  |:
Mouse    26 EDNSNQNG---AVSLIFSLKEEVGALAKVLRLFEENEINLTHIESRPSRLNKDEYEFFTYL--DK 85

  Fly   132 RR---LDQVVKMLNREV-ASVNYTSVNTQGLARAPSLSACSSFDFGDMVWFPRKISDLDK-AQNV 191
            |.   |..::|.|..:: |:|:..|.:.:.               ..:.||||.|.:||: |..:
Mouse    86 RSKPVLGSIIKSLRNDIGATVHELSRDKEK---------------NTVPWFPRTIQELDRFANQI 135

  Fly   192 LMYGSELDADHPGFKDPVYRKRREQFSAIANNFKHGNPIPRVQYTPEEVKTWGTVFLELHRLYVL 256
            |.||:|||||||||||||||.||:||:.||.|::||.|||||:||.||.|||||||..|..||..
Mouse   136 LSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYTEEERKTWGTVFRTLKALYKT 200

  Fly   257 HAVPEYMDNWPELEKYCGYREDNVPQLQDVSVYLKRKTGFQLRPVAGYLSPRDFLSGLAFRVFHC 321
            ||..|:...:|.||||||:||||:|||:|||.:|:..|||:||||||.||.||||.|||||||||
Mouse   201 HACYEHNHIFPLLEKYCGFREDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHC 265

  Fly   322 TQYIRHSSDPFYTPEPDCCHELLGHMPLLANSSFAQFSQEIGLASLGASDADIEKLATLYFFTVE 386
            ||||||.|.|.||||||.|||||||:||.::.||||||||||||||||.|..||||||:|:||||
Mouse   266 TQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVE 330

  Fly   387 FGLCKQADSTFKVYGAGLLSSVAELQHAITAENKIKKFDPEVTCQQECIITSYQNAYYYTDSFEE 451
            |||||:.|| .|.||||||||..|||:.::.:.|:...:.|.|..||..:|.:|..||..:||.:
Mouse   331 FGLCKEGDS-IKAYGAGLLSSFGELQYCLSDKPKLLPLELEKTACQEYTVTEFQPLYYVAESFND 394

  Fly   452 AKEQMRAFAESIQRPFGVRYNPYTMSVEVLSNAKKITAVVSELRGDLSIVCSALRKISA 510
            |||::|.||.:|.|||.|||:|||..||||.|.:::..:...:..::.|:|.||:||.:
Mouse   395 AKEKVRTFAATIPRPFSVRYDPYTQRVEVLDNTQQLKILADSINSEVGILCHALQKIKS 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trh	NP_612080.1	Trp_5_monoox	34..509	CDD:130337	233/446 (52%)
		ACT_TPH	79..152	CDD:153201	23/76 (30%)
		Biopterin_H	177..506	CDD:278766	204/329 (62%)
Pah	NP_032803.2	Phe4hydrox_tetr	20..452	CDD:130335	233/446 (52%)
		ACT_PAH	21..110	CDD:153203	26/88 (30%)
		Biopterin_H	119..449	CDD:278766	204/330 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54212
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100921
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730