Protein Alignment Trh and tph-1

DIOPT Version :9

• Sequence 1: NP_612080.1
• Gene: Trh / 38121
• FlyBaseID: FBgn0035187
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_495584.4
• Gene: tph-1 / 174227
• WormBaseID: WBGene00006600
• Length: 532
• Species: Caenorhabditis elegans
• Alignment Length: 484
• Identity: 227/484 - (46%)
• Similarity: 308/484 - (63%)
• Gaps: 58/484 - (11%)

  Fly    75 PGERISIIFTLRNQVGNLARALQVFQELGINVL----------------------HLELSPLEMA 117
            |.|.:..:||....|...|...:..:|.|:.:|                      |..:..||..
 Worm    56 PEEDVKQLFTPTRTVRREASIREGDEEEGVQILTIIVKSSRVSEDISKMIANLPDHTRIKHLETR 120

  Fly   118 TNQ------ADVLVDVEC----DQRRLDQVVKMLN----REVAS-VNYTSVNTQGLARAPSLSAC 167
            .:|      .|||:::|.    .|..:|  :..||    .||:| :..|::..| .....|..|.
 Worm   121 DSQDGSSKTMDVLLEIELFHYGKQEAMD--LMRLNGLDVHEVSSTIRPTAIKEQ-YTEPGSDDAT 182

  Fly   168 SSFDFGDMVWFPRKISDLD-KAQNVLMYGSELDADHPGFKDPVYRKRREQFSAIANNFKHGNPIP 231
            :..:     |||:.|.||| .|:.|:|||:.||||||||||..||:||..|:.:|.|:|||.|||
 Worm   183 TGSE-----WFPKSIYDLDICAKRVIMYGAGLDADHPGFKDTEYRQRRMMFAELALNYKHGEPIP 242

  Fly   232 RVQYTPEEVKTWGTVFLELHRLYVLHAVPEYMDNWPELEKYCGYREDNVPQLQDVSVYLKRKTGF 296
            |.:||..|.||||.::.:|..|:..||..:::||:..||::|||.|:|:|||:|:..:||.||||
 Worm   243 RTEYTSSERKTWGIIYRKLRELHKKHACKQFLDNFELLERHCGYSENNIPQLEDICKFLKAKTGF 307

  Fly   297 QLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANSSFAQFSQE 361
            ::||||||||.||||:|||:|||.||||:||.:|||||||||..|||:|||.|.|:..|||||||
 Worm   308 RVRPVAGYLSARDFLAGLAYRVFFCTQYVRHHADPFYTPEPDTVHELMGHMALFADPDFAQFSQE 372

  Fly   362 IGLASLGASDADIEKLATLYFFTVEFGLCKQ--ADS----------TFKVYGAGLLSSVAELQHA 414
            |||||||||:.|::||||||||::||||...  |||          .|||||||||||..|||||
 Worm   373 IGLASLGASEEDLKKLATLYFFSIEFGLSSDDAADSPVKENGSNHERFKVYGAGLLSSAGELQHA 437

  Fly   415 ITAENKIKKFDPEVTCQQECIITSYQNAYYYTDSFEEAKEQMRAFAESIQRPFGVRYNPYTMSVE 479
            :.....|.:|||:...:|||:||::|:||:||.:||||::::|.|..:::|||.|||||||.|||
 Worm   438 VEGSATIIRFDPDRVVEQECLITTFQSAYFYTRNFEEAQQKLRMFTNNMKRPFIVRYNPYTESVE 502

  Fly   480 VLSNAKKITAVVSELRGDLSIVCSALRKI 508
            ||:|::.|...|:.||.|::::..||..|
 Worm   503 VLNNSRSIMLAVNSLRSDINLLAGALHYI 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trh	NP_612080.1	Trp_5_monoox	34..509	CDD:130337	227/484 (47%)
		ACT_TPH	79..152	CDD:153201	22/109 (20%)
		Biopterin_H	177..506	CDD:278766	197/341 (58%)
tph-1	NP_495584.4	Trp_5_monoox	57..532	CDD:130337	226/483 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159582
Domainoid	1	1.000	416	1.000	Domainoid score	I330
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1019
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54212
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	1	1.000	-	-		oto19826
orthoMCL	1	0.900	-	-		OOG6_100921
Panther	1	1.100	-	-	LDO	PTHR11473
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3230
SonicParanoid	1	1.000	-	-		X2372
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.940