DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trh and TPH2

DIOPT Version :9

Sequence 1:	NP_612080.1	Gene:	Trh / 38121	FlyBaseID:	FBgn0035187	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_775489.2	Gene:	TPH2 / 121278	HGNCID:	20692	Length:	490	Species:	Homo sapiens

Alignment Length:	499	Identity:	260/499 - (52%)
Similarity:	345/499 - (69%)	Gaps:	27/499 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 WLYRSGEQEWAVKQGSPLHQLKKDSTTSGSSSHPSLGRNASAPPEPPRLAIGGGGQDNGRQHSPG 76
            |..|....:.||.:.   |||...||.    :.|:.|:|...         |..|.......:..
Human    13 WARRGFSLDSAVPEE---HQLLGSSTL----NKPNSGKNDDK---------GNKGSSKREAATES 61

  Fly    77 ERISIIFTLRNQVGNLARALQVFQELGINVLHLELSPLEMATNQADVLVDVECDQRRLDQVVKML 141
            .:.:::|:|:|:||.|.:||::|||..:|::|:|.......:::.::.||.||.:...::::::|
Human    62 GKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLL 126

  Fly   142 NREVASVNYTSVNTQGLARAPSLSACSSFDFGDMVWFPRKISDLDK-AQNVLMYGSELDADHPGF 205
            ..:...|.         ...|........:..|:.|||||||:||| :..|||||||||||||||
Human   127 KFQTTIVT---------LNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGF 182

  Fly   206 KDPVYRKRREQFSAIANNFKHGNPIPRVQYTPEEVKTWGTVFLELHRLYVLHAVPEYMDNWPELE 270
            ||.|||:||:.|..:|..:|:|.|||||:||.||.||||.||.||.:||..||..||:.|:|.|.
Human   183 KDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLT 247

  Fly   271 KYCGYREDNVPQLQDVSVYLKRKTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTP 335
            |||||||||||||:|||::||.::||.:|||||||||||||:|||:|||||||||||.|||.|||
Human   248 KYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTP 312

  Fly   336 EPDCCHELLGHMPLLANSSFAQFSQEIGLASLGASDADIEKLATLYFFTVEFGLCKQADSTFKVY 400
            |||.|||||||:||||:..|||||||||||||||||.|::||||.||||:||||||| :...:.|
Human   313 EPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQ-EGQLRAY 376

  Fly   401 GAGLLSSVAELQHAITAENKIKKFDPEVTCQQECIITSYQNAYYYTDSFEEAKEQMRAFAESIQR 465
            |||||||:.||:||::.:..:|.|||:.||.|||:||::|.||:.::|||||||:||.||:||.|
Human   377 GAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITR 441

  Fly   466 PFGVRYNPYTMSVEVLSNAKKITAVVSELRGDLSIVCSALRKIS 509
            ||.|.:||||.|:|:|.:.:.|..||.:||.||:.||.||.|::
Human   442 PFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMN 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trh	NP_612080.1	Trp_5_monoox	34..509	CDD:130337	253/475 (53%)
		ACT_TPH	79..152	CDD:153201	20/72 (28%)
		Biopterin_H	177..506	CDD:278766	222/329 (67%)
TPH2	NP_775489.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..58		7/39 (18%)
		Trp_5_monoox	52..485	CDD:130337	246/442 (56%)
		ACT	64..137	CDD:298841	20/81 (25%)
		Biopterin_H	152..482	CDD:278766	222/330 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147584
Domainoid	1	1.000	492	1.000	Domainoid score	I366
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	537	1.000	Inparanoid score	I1200
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54212
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	1	1.000	-	-		otm40657
orthoMCL	1	0.900	-	-		OOG6_100921
Panther	1	1.100	-	-	LDO	PTHR11473
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2372
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770