DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trh and th

DIOPT Version :9

Sequence 1:	NP_612080.1	Gene:	Trh / 38121	FlyBaseID:	FBgn0035187	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_031756384.1	Gene:	th / 100488900	XenbaseID:	XB-GENE-992305	Length:	491	Species:	Xenopus tropicalis

Alignment Length:	439	Identity:	210/439 - (47%)
Similarity:	290/439 - (66%)	Gaps:	31/439 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 ISIIFTLR-NQVGNLARALQVFQELGINVLHLELSPLEMATNQADVL-VDVECDQRRLD-----Q 136
            ||::|:|: ::..:|:|.|:||:.....:.|||..|...:...|..| ..|.|:....|     .
Frog    76 ISLLFSLKGSKPSSLSRTLKVFETFEAKIQHLETRPGRRSVGTAGELEYFVRCEVHHSDLSTLMS 140

  Fly   137 VVKMLNREVASVNYTSVNTQGLARAPSLSACSSFDFGDMVWFPRKISDLDKAQN-VLMYGSELDA 200
            .|:.:..:|.|.....|:                      |||.||:||||..: |..:..:||.
Frog   141 SVRRVCEDVRSTREDKVH----------------------WFPTKIADLDKCHHLVTKFDPDLDL 183

  Fly   201 DHPGFKDPVYRKRREQFSAIANNFKHGNPIPRVQYTPEEVKTWGTVFLELHRLYVLHAVPEYMDN 265
            :||||.|..|||||:..:.||.|::||:|||||:|.|||:.||..|:..|..||..||..|:::.
Frog   184 EHPGFSDQEYRKRRKMIADIAFNYRHGDPIPRVEYLPEEIATWKEVYSTLRSLYPTHACKEHLEA 248

  Fly   266 WPELEKYCGYREDNVPQLQDVSVYLKRKTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSD 330
            :..||.:|||.|||:|||||||.:||.|:||.||||||.||.||||:.||||||.|||||||:|.
Frog   249 FQLLEAHCGYSEDNIPQLQDVSSFLKEKSGFTLRPVAGLLSARDFLASLAFRVFQCTQYIRHASS 313

  Fly   331 PFYTPEPDCCHELLGHMPLLANSSFAQFSQEIGLASLGASDADIEKLATLYFFTVEFGLCKQADS 395
            |.::||||||||||||:|:||:.:||||||:||||||||:|.:||||||||:|||||||||| :.
Frog   314 PMHSPEPDCCHELLGHVPILADRTFAQFSQDIGLASLGATDEEIEKLATLYWFTVEFGLCKQ-EG 377

  Fly   396 TFKVYGAGLLSSVAELQHAITAENKIKKFDPEVTCQQECIITSYQNAYYYTDSFEEAKEQMRAFA 460
            ..|.||||||||..||.||::.|.:::.|:|:....|.....:||:.|:.::||.:|||::|.:|
Frog   378 EIKAYGAGLLSSFGELLHALSDEPEVRPFNPDDAAVQPYQDQNYQSVYFISESFPDAKEKLRVYA 442

  Fly   461 ESIQRPFGVRYNPYTMSVEVLSNAKKITAVVSELRGDLSIVCSALRKIS 509
            ..|:|||.||::|||.|:|||::|.:|.:.:..||.:|..:.:||..:|
Frog   443 SHIKRPFAVRFDPYTDSIEVLNSAGRIQSSLDGLRDELQTLSNALSTLS 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trh	NP_612080.1	Trp_5_monoox	34..509	CDD:130337	209/437 (48%)
		ACT_TPH	79..152	CDD:153201	21/79 (27%)
		Biopterin_H	177..506	CDD:278766	186/329 (57%)
th	XP_031756384.1	TOH_N	2..26	CDD:403668
		ACT_TH	38..153	CDD:153202	21/76 (28%)
		Biopterin_H	158..488	CDD:395280	186/352 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010