DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bab1 and rib

DIOPT Version :9

Sequence 1:	NP_728565.1	Gene:	bab1 / 38116	FlyBaseID:	FBgn0004870	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001261085.1	Gene:	rib / 44855	FlyBaseID:	FBgn0003254	Length:	680	Species:	Drosophila melanogaster

Alignment Length:	951	Identity:	195/951 - (20%)
Similarity:	296/951 - (31%)	Gaps:	391/951 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 GRSSSVASPSSSSQQFCLRWNNYQTNLTTIFDQLLQNECFVDVTLACDGRSMKAHKMVLSACSPY 151
            |.::.|||.....|.:||||||:||||..|...|.:...:||.:|..|....:||::||:|.|||
  Fly     3 GPTAPVASSGEVGQTYCLRWNNHQTNLVQILHALHEVGSYVDCSLVVDDEQFQAHRVVLAANSPY 67

  Fly   152 FQTLLAETPCQHPIVIMRDVNWSDLKAIVEFMYRGEINVSQDQIGPLLRIAEMLKVRGL------ 210
            ||.:|.:.|..|..:|:..|...::.|::::||.||..|::.|...:||.|:.|:|:||
  Fly    68 FQHILKDVPQDHCSIILPGVKGFEIAALLQYMYTGETTVTKSQEPEILRTAKELQVKGLYDNLMK 132

  Fly   211 ---ADVTHMEAATAAAAAASSERMPSSPKESTSTSRTEHDREREAEELLAFMQPEKKLRTSDWDP 272
               |.||  ..:::.|..|..:...:|...|:..|.:.|
  Fly   133 FNHASVT--PTSSSGAGGAKPQNGSASNHSSSVISTSTH-------------------------- 169

  Fly   273 AELRLSPLERQQGRNVRKRRWPSADTIFNPPAPPSPLSSLIAAERMELEQKERERQRDCSLMTPP 337
                                          .:|.:.:||                  .||   ||
  Fly   170 ------------------------------ISPSAAISS------------------SCS---PP 183

  Fly   338 PKPPMSSGSTVGATRRLETAIHALDMPSPAATPGPLSRSSRPHSQSPQQQQAQQQGQLPL-PLPL 401
            |.|..                        ...||        :|..| |||.....|:|. ..||
  Fly   184 PPPQF------------------------GYQPG--------YSHYP-QQQPMSASQIPAGEAPL 215

  Fly   402 HPHHHASPAPHPSQTAGSAHHPASPAGDS--RFPLGPAAAMA--------AA-------RELSGL 449
            .|            |..:.|..||.||::  ::||.|:||.|        ||       ::||.:
  Fly   216 TP------------TQATPHSAASGAGEAGGQWPLTPSAAAAMLNSVYESAADMNPLKRKKLSAI 268

  Fly   450 G---------------------------PGP-SAEPRLPPPPPHHH----GGGGVGGGGVGGGGA 482
            .                           ||| :|.....|..||.:    .|.||.||...
  Fly   269 SSMLLSGNRDTPILRNVLAQANPADSSQPGPMNANGEKTPTHPHQNTQLPAGLGVSGGERN---- 329

  Fly   483 GGVGSGGGSSLADDLEIKPGIAEMIREEERAKMMENSHAWMGATGSTLAADSYQYQLQSMWQKCW 547
               .|..||....|.|......:...|||..:.......|
  Fly   330 ---HSFNGSDYGGDKEPLSPYTDRSFEEETGQSGGKKPEW------------------------- 366

  Fly   548 NTNQNLMHHMRFRERGPLKSWRPETMAEAIFSV--LKEGLSLSQAARKYDIPYPTFVLYANRVHN 610
                              |.::..|.|:.:.::  ::||:|..||:|||.:|..|......:::.
  Fly   367 ------------------KRYKQYTRADMMCAIQAVREGMSALQASRKYGLPSRTLYDKVRKLNI 413

  Fly   611 MLGPSIDGGPDLRPKGRGRPQRIL-----------LGIWPDEHIKGVIKTVVFRDTKDIKDESLA 664
            ..|......|...|.|....|...           .|.....|             .::|.:...
  Fly   414 TTGRGTHRTPKRSPPGAESSQGFSYSAAAAAAAHNYGHGHGHH-------------SEVKRDQKV 465

  Fly   665 AHMPPYGRHSPAFPLQDLPLSYPGASGALAGAPSSMACPNGSGPQTGVGVAGEQHMSQETAAAVA 729
            .|:|.:....|..|        |.|:..|..|....|..|..|     .:||.:.:.   |.|:|
  Fly   466 DHVPAHHGMPPTIP--------PSAAALLDHAFLQQALENRGG-----DMAGREALH---AMALA 514

  Fly   730 AVAHNIRQQMQMAAVPPGLFNLPPHPGVGGGVGNVPGAAGGRASISPA----LSSGSGPRHAPSP 790
            |.||                                 ||..|.|.|||    .|:|.|.| :|||
  Fly   515 AAAH---------------------------------AAANRLSSSPAEMDQRSNGHGMR-SPSP 545

  Fly   791 CGPAGLLPNLPPSMAVALHHQQQQQAAHHHMQQLHLQQQQAHLHHHQQQQQQQQQQHHQGGHQVA 855
            .|               .|:..:|:|     ..|.:::.:.::...::.|.:::....:..|:..
  Fly   546 QG---------------RHYPHEQEA-----MDLEMEKHEQNIIKRERDQDEREDADDEEDHEQE 590

  Fly   856 HKSGFGASSSSSASSSSMGQHHAPKAKSSPLRSETPRLHSPLGDLGLDMASYKREFSPSRLFAED 920
            |           ....|:.:...|.:..||..:|
  Fly   591 H-----------VEDLSLARKERPPSPYSPQPTE------------------------------- 613

  Fly   921 LAELVGASVSSSSSSAAAATAPPERSAGAASAATGADAPSS 961
                .||.|...:|||            :|:.....|.|||
  Fly   614 ----AGAGVIMHASSA------------SANGKDHVDYPSS 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bab1	NP_728565.1	BTB	117..216	CDD:279045	37/107 (35%)
		BTB	128..213	CDD:197585	33/93 (35%)
		HTH_psq	569..614	CDD:283007	12/46 (26%)
rib	NP_001261085.1	BTB	33..133	CDD:279045	34/99 (34%)
		BTB	44..133	CDD:197585	32/88 (36%)
		HTH_psq	373..417	CDD:283007	12/43 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010