DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bab1 and lola

DIOPT Version :9

Sequence 1:	NP_728565.1	Gene:	bab1 / 38116	FlyBaseID:	FBgn0004870	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster

Alignment Length:	1039	Identity:	218/1039 - (20%)
Similarity:	351/1039 - (33%)	Gaps:	372/1039 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 QQFCLRWNNYQTNLTTIFDQLLQNECFVDVTLACDGRSMKAHKMVLSACSPYFQTLLAETPCQHP 164
            |||||||||:|:.|.::||.||:||..||.|||.:|:.:||||:|||||||||.|||.|...:||
  Fly     5 QQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHP 69

  Fly   165 IVIMRDVNWSDLKAIVEFMYRGEINVSQDQIGPLLRIAEMLKVRGLAD----------------- 212
            |.|::||.:.:|:|::::|||||:|:||||:..||:.||.|:::||:|
  Fly    70 IFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGGVAPKPESSGHH 134

  Fly   213 -------------VTHMEAATAAAAAASSERMPSSPKESTSTSRTE------------HDR---- 248
                         ......||..|...|.: :..|.:.|:|.||..            ||.
  Fly   135 RGGKLSGAYTLEQTKRARLATGGAMDTSGD-VSGSREGSSSPSRRRRKVRRRSMENDAHDNSNSS 198

  Fly   249 --EREAEELLAFMQPEKKLRTSDWDPAELRLSP----------LERQQ---GRNVRKRRWPSADT 298
              :..|.......|....|..|.....:|...|          .::||   ..||.|:. .||..
  Fly   199 VLQAAASNQSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTSTNVTKKT-ESAKL 262

  Fly   299 IFNPPAPPSPLSSLIAAERMELEQKERERQRDCSLMTPPPKPPMSSGSTVGATRRLETAIHALDM 363
            ..:..||.|..|:..|.::..|.|::.:...|.  :........|.|...|.....|      |:
  Fly   263 TSSTAAPASGASASAAVQQAHLHQQQAQTTSDA--INTENVQAQSQGGAQGVQGDDE------DI 319

  Fly   364 PSPAATPGPLSRSSRPHSQSPQQQQAQQQGQLPLPLPLHPHHHASPAPHPSQTAGSAHHPASPAG 428
            ...:|..||                                 :::..|:|:..:.||.|
  Fly   320 DEGSAVGGP---------------------------------NSATGPNPASASASAVH------ 345

  Fly   429 DSRFPLGPAAAMAAARELSGLGPGPSAEPRLPPPPPHHHGGGGVGGGGVGGGGAGGVGSGGGSSL 493
                      |....::|:.:....|:.        |.|                .:.....||:
  Fly   346 ----------AGVVVKQLASVVDKSSSN--------HKH----------------KIKDNSVSSV 376

  Fly   494 ADDLEIKP-----------GIAEMIREEERAKMMENSHAWMGATGSTLAADSYQYQLQSMWQKCW 547
            ..::.|:|           .:.::..:||...|.|     :..|..|........|..:.||...
  Fly   377 GSEMVIEPKAEYDDDAHDENVEDLTLDEEDMTMEE-----LDQTAGTSQGGEGSSQTYATWQHDR 436

  Fly   548 NTNQNLMHHMRFRERGPLKSWR---------------PETMAEA---IFSVLKEGLSLSQAARKY 594
            :.::..:.....::|.|..|.:               .:.:.|:   :.:..|:|
  Fly   437 SQDELGLMAQDAQQRDPQASKQDKGEQTEGAQDEFELDDCLLESNDIVITQNKDG---------- 491

  Fly   595 DIPYPTFVLYANRVHNMLGPSIDGGPDLR------------PKGRGRPQRILLGIWPDEHIKGVI 647
                  |||:..::.|:....::....:.            |.|:..|
  Fly   492 ------FVLHVKKLGNITAAKLEENQAVAQQQGQAAVTVTGPAGQPTP----------------- 533

  Fly   648 KTVVFRDTKDIKDESLAAHMPPYGRHSPAF-PLQDLPLSYPGASGALAG------APSSMACPNG 705
             |:.     ::.:.:.|:|..|    .|.. .|...|:..|.:...|..      |.:::|..:
  Fly   534 -TIT-----ELLNAAAASHSEP----KPTLTTLTSTPIKLPSSECELINIKKIIPATTTIATHH- 587

  Fly   706 SGPQTGVGVAGE----QHMSQ----------------ETAAAVAAVAHNIRQQMQMAAVPPGLFN 750
              |.|...:...    ||:||                |.....:...|..:...|:..|.|....
  Fly   588 --PHTSSTIIHPHHIIQHVSQEPHHQEHHQQHQTIHIEEVPQTSQQHHQQQHHHQLQTVQPTHTQ 650

  Fly   751 ----LPPHPGVG---GGVGNV------PGAAGGRAS----ISPALSS-----------------G 781
                :..|||..   .|:.||      |.|:..|.|    |.|.:.:                 .
  Fly   651 VQSIITAHPGQTINLVGLRNVQLADSKPIASRIRYSRGKIIGPTVQNLQIVETHEPIQHQHHELS 715

  Fly   782 SGPRHAPS------PCGPAGLLPN-----------LPPSMAVAL--------------------- 808
            .|.::..|      |...|.::.:           ||....:.:
  Fly   716 DGTKYEISEIDLNNPNASAAIISDLVKYAEIDDIELPDGTKIGIGFAPSEITEHMQTSGGETHIT 780

  Fly   809 ---HHQQQQQAAHHHMQQLHLQQQQAHLH------HHQQ--------QQQQQQQQHHQGGHQVAH 856
               |..|:.|..|.|.|    .||..|:|      ||.|        |||..|||||| .|.:..
  Fly   781 TIEHEPQELQTVHQHEQ----TQQTHHIHAGQLQTHHIQTVVQSSSGQQQHDQQQHHQ-HHSIEL 840

  Fly   857 KSGFGASSSSSASSSSMGQHHAPKA----KSSPLRSETPRLHSPLGDLGLDMASYKREFSPSRL 916
            :...|.   .:.:...:|.|.:.|:    .:.|::.|:.  |.|.|      .:|:...|.|.|
  Fly   841 QDDDGV---ETITPEELGMHDSSKSYTILTTRPMKEESE--HDPSG------MTYELSLSDSSL 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bab1	NP_728565.1	BTB	117..216	CDD:279045	55/128 (43%)
		BTB	128..213	CDD:197585	48/114 (42%)
		HTH_psq	569..614	CDD:283007	7/62 (11%)
lola	NP_788308.3	BTB	22..117	CDD:279045	54/94 (57%)
		BTB	33..117	CDD:197585	47/83 (57%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010