DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bab1 and br

DIOPT Version :9

Sequence 1:	NP_728565.1	Gene:	bab1 / 38116	FlyBaseID:	FBgn0004870	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster

Alignment Length:	1034	Identity:	247/1034 - (23%)
Similarity:	362/1034 - (35%)	Gaps:	357/1034 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 SQQFCLRWNNYQTNLTTIFDQLLQNECFVDVTLACDGRSMKAHKMVLSACSPYFQTLLAETPCQH 163
            :|.|||||||||:::|:.|:.|..:|.||||||||:|||:|||::|||||||||:.||..|||:|
  Fly     4 TQHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPCKH 68

  Fly   164 PIVIMRDVNWSDLKAIVEFMYRGEINVSQDQIGPLLRIAEMLKVRGL----ADVTHMEAATAAAA 224
            |:::::|||:.||.|:|||:|.||:||.|..:...|:.||:|:|.||    |:.||...|.....
  Fly    69 PVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLAQIQNL 133

  Fly   225 AASSERMPSSPKESTSTSRTEHDREREAEELLAFMQPEKKLRTSDWDPAELRLSPLERQQGRNVR 289
            |.|..|.|.    :|.|....|.......:                |...   |.|..:||..
  Fly   134 ANSGGRTPL----NTHTQSLPHPHHGSLHD----------------DGGS---STLFSRQGAG-- 173

  Fly   290 KRRWPSADTIFNPPAPPSPLSSLIAAERMELEQKERERQRDCSLMTPPPKPPMSSGSTVGATRRL 354
                       :|  ||:.:.||.:....:|.::.....|..:        ..::..|..|.:||
  Fly   174 -----------SP--PPTAVPSLPSHINNQLLKRMAMMHRSSA--------AAAAEETSHAFKRL 217

  Fly   355 ETAIHALDMPSPAATPGPLSRS--SRPHSQSPQQQQAQQQGQLPLPLPLHPHHHASPAPHPSQTA 417
            ..:.::|          |||.:  |..::.||.           || |||. ..|||...|:..:
  Fly   218 RGSDNSL----------PLSGAVGSGSNNNSPD-----------LP-PLHA-RSASPQQTPADFS 259

  Fly   418 GSAHHPASPAGDSRFPLGPAAAMAAARELSGLGPGPSAEPRLPPPPPHHHGGGGVGGGGVGGGGA 482
            ...||     .::..|                   |..|.:       .:|..|.|..|.|.|..
  Fly   260 TIKHH-----NNNNTP-------------------PLKEEK-------RNGPTGNGNSGNGNGNG 293

  Fly   483 GGVGSGGGSSLADDL-EIKPGI-----AEMIREEERAKMMENSHAWMGATGSTLAADSYQYQLQS 541
            .|..:|.|.|::|.| .:.|..     |:.::.|....:..|::|        .|.|.:
  Fly   294 NGASNGNGISISDKLGSLTPSPLARAGADDVKSEPMDMVCSNNNA--------NANDEH------ 344

  Fly   542 MWQKCWNTNQNLMHHMRFRE------RGPLKSWRPETMAEAIFSVLKEGLSLSQAARKYDIPYPT 600
                   :|.:...|...|.      :|.|.|...|.:.        :||:...||       |.
  Fly   345 -------SNDSTGEHDANRSSSGDGGKGSLSSGNDEEIG--------DGLASHHAA-------PQ 387

  Fly   601 FVLYANRVHNMLGPSIDGGPDLRPKGRGRPQRILLGIWPDEHIKGVIKTVVFRDTKDIKDESLAA 665
            |:: :...:.|...:....|::.|..       |||:                :|:..:...||
  Fly   388 FIM-SPAENKMFHAAAFNFPNIDPSA-------LLGL----------------NTQLQQSGDLA- 427

  Fly   666 HMPPYGRHSPAFPLQDLPLS---YPGASGALAGAPSSMACPNGSGPQTGVGVAGEQHMSQETAAA 727
             :.|.|..:.:.      ||   .||.||   |.||:.:..|.:.....    .:|.:.|:::
  Fly   428 -VSPQGGSTGSL------LSGVIVPGGSG---GTPSNSSSNNNNNNSNN----QQQKVEQQSS-- 476

  Fly   728 VAAVAHNIRQQMQMAAVPPGLFNLPPH----------PGVGGG---VGNVPGAAGGRASI---SP 776
                .|.:.||...:.         ||          |..|||   ..::..|||...|:   |.
  Fly   477 ----PHQLLQQQHHST---------PHTNSPQLKQEQPKSGGGSCKSSDLHIAAGSERSLSRSSQ 528

  Fly   777 ALSSGSGPRHAPSPC-----------------------------------GPAGLLPNLPPSMAV 806
            .:....|....|||.                                   |..|..|..|||
  Fly   529 GMPDAGGHSATPSPTAAYHKRERERERERERERERERERSLDHERDLERPGGTGSPPPPPPS--- 590

  Fly   807 ALHH-------------QQQQQAAHHHMQQLHLQQQQAHLH----HHQQQQQQQQQQHHQGGHQV 854
              ||             ..|..|.||.:.........||.|    |...:.....:.||...|:.
  Fly   591 --HHSHFGQHPLSLLPSHHQLHATHHELSAAAAHHAHAHAHAAHAHALARAGSPMEHHHLLHHRR 653

  Fly   855 AHKSGFGASSSSSASSSSMGQHHAPKAKSSPLRS--------ETPRLHSPL-----------GDL 900
            |..|..||.||:|.:....|....|......|.|        :..||..||           |.|
  Fly   654 ASLSPSGAVSSASGAGGRGGGAGGPGGPGGSLLSSVRAQDVAQANRLLLPLPLNACHRCDVCGKL 718

  Fly   901 GLDMASYKREFSPSRLFAEDLAELV----------------------------------GASVSS 931
            .....:.||......|  :.|...|                                  ||.||.
  Fly   719 LSTKLTLKRHKEQQHL--QPLNNAVCNLCHKVFRTLNSLNNHKSIYHRRQKNHHSYFHHGAGVSQ 781

  Fly   932 ------------SSSSAAAATAPPERSAGAASA------ATGADAPSSSSSGGIKVEPI 972
                        ||.|||||.|....:.|..|.      |..|.|.:::::..:.:.||
  Fly   782 AGSPGSRLHQSLSSLSAAAAAANNSVNVGGGSVGGAGGNAVAAAAAAAAAAAELLLSPI 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bab1	NP_728565.1	BTB	117..216	CDD:279045	57/102 (56%)
		BTB	128..213	CDD:197585	51/88 (58%)
		HTH_psq	569..614	CDD:283007	8/44 (18%)
br	NP_001162638.2	BTB	22..118	CDD:279045	55/95 (58%)
		BTB	33..118	CDD:197585	50/84 (60%)
		C2H2 Zn finger	712..729	CDD:275368	4/16 (25%)
		C2H2 Zn finger	742..763	CDD:275368	0/20 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010