DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bab1 and ab

DIOPT Version :9

Sequence 1:	NP_728565.1	Gene:	bab1 / 38116	FlyBaseID:	FBgn0004870	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	974	Identity:	229/974 - (23%)
Similarity:	349/974 - (35%)	Gaps:	291/974 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 AGGGGSSPVSSPQGRSSSVASPSSSSQQFCLRWNNYQTNLTTIFDQLLQNECFVDVTLACDGRSM 138
            |.|...||.:.|...:.| .......|.:.|:||::|:::.:.|..|...|.|||||||||.||.
  Fly    51 ATGSALSPATPPPSLNLS-HQQQQHQQHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSF 114

  Fly   139 KAHKMVLSACSPYFQTLLAETPCQHPIVIMRDVNWSDLKAIVEFMYRGEINVSQDQIGPLLRIAE 203
            .|||:|||||||||:.||...||:|||||:|||...|::.::.|||.||:|||.:|:...|:.|.
  Fly   115 TAHKVVLSACSPYFRRLLKANPCEHPIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAH 179

  Fly   204 MLKVRGLADVT----HMEAATAAAAAASSERMPSSPKESTSTSRTEHDREREAE-----ELLAFM 259
            :|::||||||.    :.:|.:||.:..||....::...:.|.|...::....||     ::.:::
  Fly   180 LLQIRGLADVNGGYPYSKALSAALSHNSSNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYL 244

  Fly   260 QPEK---KLRTSDWDPAELRLSPLERQQGRNVRKRRWPSADTIFNPPAPPSPL------------ 309
            .|.:   ....|....:....|........|:......|.::.|:.|..|.|:
  Fly   245 SPNQTSAACNNSSNSNSNNHSSSHNNSSSNNISGSLNSSLNSPFSAPQIPPPVTASSAAAAAAAA 309

  Fly   310 SSLIAA------------------------------------------------------ERMEL 320
            :||.||                                                      ...::
  Fly   310 ASLTAAVAAAAAATAASAGSSSSAASGQTSGTPAIQELKASSAASPVRNPNPNPSKASSSNHWDM 374

  Fly   321 EQKERERQRDCSLMTPPPKPPMSSGSTVGATRRLETAIHALDMPSPAATPGPL--SRSSRPHSQS 383
            .:.|..|:   |.:||||:..:.|.....|...:......||...|.|...||  :||.|..|:.
  Fly   375 GEMEGSRK---SHLTPPPQKRIKSADLFRAQHGISPERLLLDREFPVAGQHPLTRNRSGRDTSKD 436

  Fly   384 PQQQQAQQQGQLPLPLPLHPHHHASPAPHPSQTAG----SAHHPASPAGDSR------------- 431
            .::....::..|...|.......|:|.....|:||    |:....|..||.:
  Fly   437 RERNLELRESLLGQALENSNGQQANPKHELGQSAGEDSNSSDTEPSDRGDGQHDGTLDGIDNQRS 501

  Fly   432 --FPLGPAAAMAAARELSGLGPGPSAEPRLPPPPPHHHGGGGVGGGGVGGGGAGGVGSGGGSSLA 494
              ||    .|....:.:.||.||||                             |:.|...|..:
  Fly   502 HSFP----NAFLGLQGIPGLLPGPS-----------------------------GINSDFVSRRS 533

  Fly   495 DDLEIK-------PGIAEMIREEERAKM-MENSHAWMGATGSTLAADSYQYQLQSMWQKCWNTNQ 551
            .::.::       |...::.|.....:. :|:.|.         ....|:..|.....|    ::
  Fly   534 LEMRVRATDPRPCPKCGKIYRSAHTLRTHLEDKHT---------VCPGYRCVLCGTVAK----SR 585

  Fly   552 NLMH-HMRFRERG---------PLKS-WRPETMAEAIFSVLKEGLSLSQAARKYDIPYPTFVLYA 605
            |.:| ||..:.||         |:.| :.||..:..:   .|.|:.:|.|..:
  Fly   586 NSLHSHMSRQHRGISTKDLPVLPMPSAFDPELASRLL---AKAGVKISPAELR------------ 635

  Fly   606 NRVHNMLGPSIDGGPDLRPKGRGRPQRILLGIWPDEHIKGVIKTVVFRDTKDIKD--ESLAAHMP 668
            .|.....|....||     .|.|...:..|.:   .:..|    ....|.:|..|  |.|.....
  Fly   636 ARASPTGGSGSSGG-----GGGGGSSQAKLDL---SNASG----GPMDDAEDSDDDPEDLTTGNG 688

  Fly   669 PYGRHSPAFPL---QDLPLSYPG------------ASGALAGAPSSMA--CPNGSGP-------- 708
            .||....:..|   .:..||..|            |:.|..|.|..:.  .||.:.|
  Fly   689 LYGMGGSSSDLSRYHESLLSNFGHARMRNEAAAVAATAAALGQPKDLGVQLPNSNAPGQSLLDTY 753

  Fly   709 -------QTGVGVAGEQHMSQETAAAVAAVAHNIRQQM-QMAAVPPGLFNLPPHPGVGGGVGNVP 765
                   ..|:|      ||||.|||.|     :|.:| |:.|:...|.||||        |.:|
  Fly   754 LQFITENTFGMG------MSQEQAAAAA-----LRAKMAQLNAMGHSLDNLPP--------GLLP 799

  Fly   766 G-------AAGGRASISPALSSGSGP--------RHAPSPCGPAGLLPNLPPSMAVALHHQQQQQ 815
            |       |||     :||... |||        ||..:    ||   ||.|:..:|| :...:.
  Fly   800 GQFDLSKLAAG-----NPAFGQ-SGPGLTIEPIMRHEQA----AG---NLSPNRPLAL-NSGGRM 850

  Fly   816 AAHHHMQQLHLQQQQAHLHHHQQQQQQQQQQHHQGG--HQVAHKSGFGASSSSSASSSSMGQHH 877
            ..|..|     .:....:.....:.......::|.|  |:||:      |.:....|...|.|:
  Fly   851 MGHDEM-----AENDGDMRREGSEPMDLGLDNNQSGSNHEVAN------SDAEENYSEDEGVHN 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bab1	NP_728565.1	BTB	117..216	CDD:279045	57/102 (56%)
		BTB	128..213	CDD:197585	50/84 (60%)
		HTH_psq	569..614	CDD:283007	7/44 (16%)
ab	NP_476562.1	BTB	93..189	CDD:279045	55/95 (58%)
		BTB	104..189	CDD:197585	50/84 (60%)
		zf-Di19	545..597	CDD:283297	11/64 (17%)
		C2H2 Zn finger	546..567	CDD:275371	3/20 (15%)
		C2H2 Zn finger	575..596	CDD:275371	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447064
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.940