Protein Alignment bab1 and NACC2

DIOPT Version :9

• Sequence 1: NP_728565.1
• Gene: bab1 / 38116
• FlyBaseID: FBgn0004870
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_653254.1
• Gene: NACC2 / 138151
• HGNCID: 23846
• Length: 587
• Species: Homo sapiens
• Alignment Length: 738
• Identity: 143/738 - (19%)
• Similarity: 201/738 - (27%)
• Gaps: 327/738 - (44%)

  Fly   126 FVDVTLACDGRSMKAHKMVLSACSPYFQTLLA-------ETPCQHPIVIMRDVNWSDLKAIVEFM 183
            :.||::...|::.|||:.||:|.|.||:.|.:       |.|...|....:.        |:.|.
Human    29 YCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGSVPPACFQQ--------ILSFC 85

  Fly   184 YRGEINVSQDQIGPLLRIAEMLKVRGLAD----------VTHMEAATAAAAAASSERMPSSPKES 238
            |.|.:.::..:...::..|..|:::.:.:          ..|.::.||....|.||  |.||
Human    86 YTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAVIEDAGSE--PQSP--- 145

  Fly   239 TSTSRTEHDREREAEELLAFMQPEKKLRTSDWDPAELRLSPLERQQGRNVRKRRWPSADTIFNPP 303
                                        .:...||....:|                   ....|
Human   146 ----------------------------CNQLQPAAAAAAP-------------------YVVSP 163

  Fly   304 APPSPLSSLIAAERMELEQKERERQRDCSLMTPP------PKPPMSSGSTVGATRRLETAIHA-- 360
            :.|.||.:.:..|.|||               ||      ||.|:.:|...|.......|:.|
Human   164 SVPIPLLTRVKHEAMEL---------------PPAGPGLAPKRPLETGPRDGVAVAAGAAVAAGT 213

  Fly   361 -----------------------LDMPSP---AATPGPLSRSSRPHSQSP---------QQQQA- 389
                                   ..||.|   ..:||   .||.|.:.||         :..:|
Human   214 APLKLPRVSYYGVPSLATLIPGIQQMPYPQGERTSPG---ASSLPTTDSPTSYHNEEDEEDDEAY 275

  Fly   390 -----QQQGQL-------------PLPLPLHPHH--------HASPAPHPSQTAGSAHHPASPAG 428
                 :|.||:             |.|:||....        .|.||...||.....|......|
Human   276 DTMVEEQYGQMYIKASGSYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEG 340

  Fly   429 DSRFPLGPAAAMAAARELSGLGPGPSAEPRLPPPPPHHHGGGGVGGGGV---------------- 477
            |                     ||...|.              |.|.||
Human   341 D---------------------PGEKLEL--------------VAGSGVYITRGQLMNCHLCAGV 370

  Fly   478 ---------------GGGGAGGVGSGGGSSLADDLEIKP--------------GIAEMIREEERA 513
                           ....|...|:|..||.:|... ||              ..|...:|.|.
Human   371 KHKVLLRRLLATFFDRNTLANSCGTGIRSSTSDPSR-KPLDSRVLNAVKLYCQNFAPSFKESEM- 433

  Fly   514 KMMENSHAWMGATGSTLAADSYQYQLQSMWQKCWNTNQNLMHHMRFRERGPLKSWRPETMAEAIF 578
                          :.:|||           .|.|..       |.|:|     |.|:     |.
Human   434 --------------NVIAAD-----------MCTNAR-------RVRKR-----WLPK-----IK 456

  Fly   579 SVLKEGLSLSQAARKYDIPYPTFVLYANRVHNMLGPSIDGGPDLRP-KGRGRPQRILLGIWPDEH 642
            |:|.||:.:          |.|       |......|:...|:..| ..:...|||.      ..
Human   457 SMLPEGVEM----------YRT-------VMGSAAASVPLDPEFPPAAAQVFEQRIY------AE 498

  Fly   643 IKGVIKTVVFRDTKDIK-DESLAAHMPPYGRHSPAFPLQDLPLSYPGASGAL--AGAPSSMACPN 704
            .:|...|:|...|..:. |.|.||        :|||   |......||...:  ..||..:....
Human   499 RRGDAATIVALRTDAVNVDLSAAA--------NPAF---DAGEEVDGAGSVIQEVAAPEPLPADG 552

  Fly   705 GSGPQTGVGVAGEQHMSQETAAA 727
            .|.||......|.....|..|||
Human   553 QSPPQPFEQGGGGPSRPQTPAAA 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bab1	NP_728565.1	BTB	117..216	CDD:279045	22/106 (21%)
		BTB	128..213	CDD:197585	22/101 (22%)
		HTH_psq	569..614	CDD:283007	9/44 (20%)
NACC2	NP_653254.1	BTB	20..120	CDD:279045	22/98 (22%)
		BTB	31..114	CDD:197585	22/90 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..272		9/34 (26%)
		BEN	373..450	CDD:214981	18/110 (16%)
		TIM_phosphate_binding	496..>581	CDD:304361	24/97 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..587		10/34 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	80	1.000	Inparanoid score	I5230
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050