DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bab1 and NACC1

DIOPT Version :9

Sequence 1:	NP_728565.1	Gene:	bab1 / 38116	FlyBaseID:	FBgn0004870	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_443108.1	Gene:	NACC1 / 112939	HGNCID:	20967	Length:	527	Species:	Homo sapiens

Alignment Length:	385	Identity:	90/385 - (23%)
Similarity:	128/385 - (33%)	Gaps:	127/385 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LTTIFDQLLQNECFVDVTLACDGRSMKAHKMVLSACSPYFQTL-------LAETPCQHPIVIMRD 170
            |..:.:|.||. .:.||::...|.:.|||:.||:|.|.||:.|       :.|.|..
Human    17 LECLNEQRLQG-LYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNNSRSAVVELPAA-------- 72

  Fly   171 VNWSDLKAIVEFMYRGEINVSQDQIGPLLRIAEMLKVRGLADVTHMEAATAAAAAASSERMPSSP 235
            |.....:.|:.|.|.|.::::......|:..|..|:::.:     ||..|......||   ||..
Human    73 VQPQSFQQILSFCYTGRLSMNVGDQFLLMYTAGFLQIQEI-----MEKGTEFFLKVSS---PSCD 129

  Fly   236 KESTSTSRTEHDREREAEELLAFMQPEKKLRTSDWDPAELRLSPLERQQGRNVRKRRWPSADTIF 300
            .:..      |..|..:.|      |:               ||:.:..|       ||:..|
Human   130 SQGL------HAEEAPSSE------PQ---------------SPVAQTSG-------WPACST-- 158

  Fly   301 NPPAPPSPLSSLIAAERMELEQKERERQRDCSLMTPPPKPPMSSG-STVGATRRLETAIHALDMP 364
                 |.||.|     |::.||:|    .|.....|..|....|| ...|........:.....|
Human   159 -----PLPLVS-----RVKTEQQE----SDSVQCMPVAKRLWDSGQKEAGGGGNGSRKMAKFSTP 209

  Fly   365 SPAATPGPLSRSSRPHSQSPQQQQAQQQGQLPLPLPLHPHHHASPAPHPSQTAGSAHHPASPAGD 429
            ..||        :|||...|.||                      ||     ..:|..||..||.
Human   210 DLAA--------NRPHQPPPPQQ----------------------AP-----VVAAAQPAVAAGA 239

  Fly   430 SRFPLGPAAAMAAARELSGLGPGPSAEPRLPP----------PPPHHHGGGGVGGGGVGG 479
            .:    ||..:|||   .|:..|||...|..|          |..:|:.......||..|
Human   240 GQ----PAGGVAAA---GGVVSGPSTSERTSPGTSSAYTSDSPGSYHNEEDEEEDGGEEG 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bab1	NP_728565.1	BTB	117..216	CDD:279045	26/105 (25%)
		BTB	128..213	CDD:197585	23/91 (25%)
		HTH_psq	569..614	CDD:283007
NACC1	NP_443108.1	BTB_POZ_BTBD14B_NAC1	3..125	CDD:349599	30/121 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..153		7/55 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..292		30/123 (24%)
		BEN	396..474	CDD:214981
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	80	1.000	Inparanoid score	I5230
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050