DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9205 and OSBPL10

DIOPT Version :9

Sequence 1:	NP_612075.1	Gene:	CG9205 / 38113	FlyBaseID:	FBgn0035181	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	XP_005264900.1	Gene:	OSBPL10 / 114884	HGNCID:	16395	Length:	769	Species:	Homo sapiens

Alignment Length:	250	Identity:	82/250 - (32%)
Similarity:	114/250 - (45%)	Gaps:	60/250 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RESAKLKLCGQLSKYTNVMKGWQYRWFTVDAKTGSLSYYLCDSSTVGDDIAPSPHVLASAPRGQV 74
            ||.|   |.|.||||||:::|||.|:|.:|.:.|.|.|::.:.         |.|   ..|||.:
Human    73 REPA---LEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQ---------SKH---QKPRGVL 122

  Fly    75 QLAGAVVYPSDEDSRTFAIACASGDTVKLRANDARARQEWVDGLRAVVESHMKAMDIS------- 132
            .|:||:|..|||......:..|:|:..||||.||:.:|.||..|||..:.||:....|
Human   123 SLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKEKQFWVTQLRACAKYHMEMNSKSAPSSRSR 187

  Fly   133 -----------NSSPLPPRELLAASDAMVS-----------------------ARQALFLTEQCN 163
                       ::||...|.|...:..:|:                       .|:.:...|...
Human   188 SLTLLPHGTPNSASPCSQRHLSVGAPGVVTITHHKSPAAARRAKSQYSGQLHEVREMMNQVEGQQ 252

  Fly   164 ASLARAIESI-DCASFSPTDPDLLLLKAISTASTQCLHQCLGLLQR--HQEINQP 215
            .:|..||||: .....:..|.|||||||.|.|:..||.:||.|||:  || ..||
Human   253 KNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLNLLQQSVHQ-AGQP 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9205	NP_612075.1	PH	15..123	CDD:278594	43/107 (40%)
CG9205	NP_612075.1	PH_ORP10_ORP11	17..135	CDD:270106	46/135 (34%)
OSBPL10	XP_005264900.1	PH_ORP10_ORP11	77..183	CDD:270106	46/117 (39%)
		PH	78..171	CDD:278594	42/104 (40%)
		Oxysterol_BP	402..750	CDD:279564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	93	1.000	Domainoid score	I7559
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810