DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and HXT5

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_011964.1	Gene:	HXT5 / 856496	SGDID:	S000001138	Length:	592	Species:	Saccharomyces cerevisiae

Alignment Length:	502	Identity:	141/502 - (28%)
Similarity:	233/502 - (46%)	Gaps:	74/502 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FLTYSIFSAVLGMLQFGYNTGVIN-------------APEKNIENFMKDVYKDRYGEDISEEFIQ 63
            |::........|...||::||.|:             :...|...::.||   |.|
Yeast    85 FVSVCCLMVAFGGFVFGWDTGTISGFVRQTDFIRRFGSTRANGTTYLSDV---RTG--------- 137

  Fly    64 QLYSVAVSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRF 128
                :.||||.||..:||.....:.:.:|||.||:...|:...| .::....:...|: .|:||.
Yeast   138 ----LMVSIFNIGCAIGGIVLSKLGDMYGRKIGLMTVVVIYSIG-IIIQIASIDKWYQ-YFIGRI 196

  Fly   129 IIGVNCGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEG------- 186
            |.|:..|..|.|.||.|||::|..|||.|.:..||.:|.|:.|...        ||.|
Yeast   197 ISGLGVGGITVLAPMLISEVSPKQLRGTLVSCYQLMITFGIFLGYC--------TNFGTKNYSNS 253

  Fly   187 --WPILLGLAICPAILQLILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEE------DIE 243
              |.:.|||....:|..::.:...|||||||:...: .|||:::|  .||:.:.|:      ::|
Yeast   254 VQWRVPLGLCFAWSIFMIVGMTFVPESPRYLVEVGK-IEEAKRSL--ARANKTTEDSPLVTLEME 315

  Fly   244 EMRAEERAQQSESHISTMELIC-SPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEE 307
            ..::...|::.....|..||:. .|.:....::|:::|..||.:|.|..|||.|::|.:.|| |:
Yeast   316 NYQSSIEAERLAGSASWGELVTGKPQMFRRTLMGMMIQSLQQLTGDNYFFYYGTTIFQAVGL-ED 379

  Fly   308 SAKFATIGIGAIMVVMTLVSIPLMDRTGRRTLHLYGLGGM---FIFSIFITISFLIKEMIDWMS- 368
            |.:.|.: :|.:..|.|..|:..:||.|||...|:|..||   ::....:.::.|.....|..|
Yeast   380 SFETAIV-LGVVNFVSTFFSLYTVDRFGRRNCLLWGCVGMICCYVVYASVGVTRLWPNGQDQPSS 443

  Fly   369 ----YLSVVATLGFVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMK 429
                ...:|....::..||.....:.:::.:|.:....|..||:||...||:..|::....|.:.
Yeast   444 KGAGNCMIVFACFYIFCFATTWAPVAYVLISESYPLRVRGKAMSIASACNWIWGFLISFFTPFIT 508

  Fly   430 TALE---NYTFLPFSVFLAIFWIFTYKKVPETKNKTFEEILALFRHN 473
            :|:.   .|.|:...|| |.|::|.:  |||||..|.||:..::..|
Yeast   509 SAINFYYGYVFMGCMVF-AYFYVFFF--VPETKGLTLEEVNEMYEEN 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	131/474 (28%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	139/491 (28%)
HXT5	NP_011964.1	Sugar_tr	89..549	CDD:395036	139/493 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13429
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.810