DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut1 and HXT11

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_014486.1	Gene:	HXT11 / 854009	SGDID:	S000005516	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	498	Identity:	144/498 - (28%)
Similarity:	242/498 - (48%)	Gaps:	70/498 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LTFFLTYSIFSAVL--GMLQFGYNTGVINAPEKNIENFMKDVYKDRYGE--DISEEFIQQL-YSV 68
            |:.:.|.:|...::  |...||::||.|:. ..|:.:|::     |:|:  |....::.:: ..:
Yeast    55 LSAYTTVAILCLMIAFGGFIFGWDTGTISG-FVNLSDFIR-----RFGQKNDKGTYYLSKVRMGL 113

  Fly    69 AVSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVN 133
            .||||.||..:||.....:.:.:||:.||:....:.:.| .|:..|.::..|: .|:||.|.|:.
Yeast   114 IVSIFNIGCAIGGIVLSKVGDIYGRRIGLITVTAIYVVG-ILIQITSINKWYQ-YFIGRIISGLG 176

  Fly   134 CGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEG---------WPI 189
            .|....|.||.|||:||.::||.|..:.||..|:|:.|...        ||.|         |.:
Yeast   177 VGGIAVLSPMLISEVAPKHIRGTLVQLYQLMGTMGIFLGYC--------TNYGTKNYHNATQWRV 233

  Fly   190 LLGLAICPAILQLILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEED-------IEEMRA 247
            .|||....|...:..:...|||||||:...: :|||:::|.:   |..|..|       .:.::|
Yeast   234 GLGLCFAWATFMVSGMMFVPESPRYLIEVGK-DEEAKRSLSK---SNKVSVDDPALLVEYDTIKA 294

  Fly   248 EERAQQSESHISTMELICSPT-LRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKF 311
            ....::...:.|..||:.:.| :...:::|:::|..||.:|.|..|||.|::|.|.||.:   .|
Yeast   295 GIELEKLAGNASWSELLSTKTKVFQRVLMGVMIQSLQQLTGDNYFFYYGTTIFKSVGLKD---SF 356

  Fly   312 AT-IGIGAIMVVMTLVSIPLMDRTGRRTLHLYGLGGMF-IFSIFITISFLIKEMIDWMSYLS--- 371
            .| |.||.:....:.:::..::|.||||..|:|...|. .|::|.::.  :.::  |....|
Yeast   357 QTSIIIGVVNFFSSFIAVYTIERFGRRTCLLWGAASMLCCFAVFASVG--VTKL--WPQGSSHQD 417

  Fly   372 ----------VVATLGFVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFP 426
                      :|.|:.|:..||.......::|.:|.|....:...||||...|||..|::....|
Yeast   418 ITSQGAGNCMIVFTMFFIFSFATTWAGGCYVIVSETFPLRVKSRGMAIATAANWMWGFLISFFTP 482

  Fly   427 SMKTALE---NYTFLPFSVFLAIFWIFTYKKVPETKNKTFEEI 466
            .:..|:.   .|.||...|| |.|::|.:  |||||..|.||:
Yeast   483 FITGAINFYYGYVFLGCLVF-AYFYVFFF--VPETKGLTLEEV 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	134/474 (28%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	141/489 (29%)
HXT11	NP_014486.1	Sugar_tr	64..526	CDD:395036	141/489 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13429
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.810