DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and HXT16

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_012692.3	Gene:	HXT16 / 853623	SGDID:	S000003919	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	482	Identity:	133/482 - (27%)
Similarity:	234/482 - (48%)	Gaps:	34/482 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FLTYSIFSAVLGMLQF-----GYNTGVINAPEKNIENFMKDV--YKDRYGEDISEEFIQQL-YSV 68
            ||.|.|...:...:.|     |:::| |.|...|::||..:.  ||...|    |.::..: ..:
Yeast    54 FLGYLIIYLLCYPVSFGGFLPGWDSG-ITAGFINMDNFKMNFGSYKHSTG----EYYLSNVRMGL 113

  Fly    69 AVSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVN 133
            .|::|::|..:||.:...:|:..||:..:::..::.:.||.:.  ...:|.:...|:|:.|.|:.
Yeast   114 LVAMFSVGCSIGGVAFARLADTLGRRLAIVIVVLVYMVGAIIQ--ISSNHKWYQYFVGKIIYGLG 176

  Fly   134 CGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLS--QVLGIEQILGTNEGWPILLGLAIC 196
            .|..:.|.||.:|||||.:|||||.::.||.:|.|:.|.  .|.|..:...|.: |.|.:||...
Yeast   177 AGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSVYGTRKYSNTAQ-WRIPVGLCFL 240

  Fly   197 PAILQLILLPVCPESPRYLLITKQWEEEARKALRRLRASGS---VEEDIEEMRAEERAQQSESHI 258
            .|::.::.:.:.|||||||:..::.||......:..:.|..   |.:..:|:.|...||:.....
Yeast   241 WALIIIVGMLLVPESPRYLIECERHEEACVSIAKIDKVSPEDPWVLKQADEINAGVLAQRELGEA 305

  Fly   259 STMELICSPT-LRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFAT-IGIGAIMV 321
            |..||....| :...||.||::|...|.:|.|..|:|.|::|.|.|||:   .|.| |.:|.:..
Yeast   306 SWKELFSVKTKVLQRLITGILVQTFLQLTGENYFFFYGTTIFKSVGLTD---GFETSIVLGTVNF 367

  Fly   322 VMTLVSIPLMDRTGRRTLHLYGLGGMFIFSIF---ITISFLIKEMIDWMS-----YLSVVATLGF 378
            ..|::::.::|:.|||...|:|...|....:.   |.:..|.....|..|     ...:|.|..:
Yeast   368 FSTIIAVMVVDKIGRRKCLLFGAASMMACMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFY 432

  Fly   379 VVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVF 443
            :..||.....:.:::.||.|....:..||:|:...||:..|::|...|.:..::..|....|...
Yeast   433 IFCFATTWAPVAYIVVAESFPSKVKSKAMSISTAFNWLWQFLIGFFTPFITGSIHFYYGYVFVGC 497

  Fly   444 LAIFWIFTYKKVPETKNKTFEEILALF 470
            |...:::.:..:|||...:.||...|:
Yeast   498 LVAMFLYVFFFLPETIGLSLEETQLLY 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	124/457 (27%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	128/474 (27%)
HXT16	NP_012692.3	Sugar_tr	63..524	CDD:278511	128/471 (27%)
HXT16	NP_012692.3	MFS	67..510	CDD:119392	123/453 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13429
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.810