DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and Slc2a8

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_445946.2	Gene:	Slc2a8 / 85256	RGDID:	620611	Length:	478	Species:	Rattus norvegicus

Alignment Length:	504	Identity:	166/504 - (32%)
Similarity:	243/504 - (48%)	Gaps:	78/504 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 APG--LTFFLTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSV 68
            |||  ..|..|   |:|.||.|.||:..|..:....::........  |.|:..:..|
  Rat    20 APGGRRVFLAT---FAAALGPLSFGFALGYSSPAIPSLRRTAPPAL--RLGDTAASWF------- 72

  Fly    69 AVSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVN 133
             .::..:|...||..|||:.:|.|||..|||..|..:.|..::   ..:....||..||.:.|:.
  Rat    73 -GAVVTLGAAAGGVLGGWLLDRAGRKLSLLLCTVPFVTGFAVI---TAARDVWMLLGGRLLTGLA 133

  Fly   134 CGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLG--IEQILGTNEGWPILLGLAIC 196
            ||:.:.:.|:||||||...:||.||:..||.|..|:||:.|.|  :|        |..|..|...
  Rat   134 CGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLE--------WRWLAVLGCV 190

  Fly   197 PAILQLILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEE--MRAEERAQQSESHIS 259
            |..|.|:|:...||:||:||...|: :||..|||.|..|   ||..||  :.||.:..|
  Rat   191 PPTLMLLLMCYMPETPRFLLTQHQY-QEAMAALRFLWGS---EEGWEEPPVGAEHQGFQ------ 245

  Fly   260 TMELICSPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKF-----ATIGIGAI 319
             :.::..|.:..||||||.:.:.||.||:||:.:|:.::|       |.|||     |::.:|.|
  Rat   246 -LAMLRRPGVHKPLIIGICLMVFQQLSGVNAIMFYANTIF-------EEAKFKDSSLASVTVGII 302

  Fly   320 MVVMTLVSIPLMDRTGRR-TLHLYGLGGMFIFSIFIT--------------ISFLI---KEMID- 365
            .|:.|.|:..:|||.||: .|.|.|:..:|..|.|.|              :..|:   .|..|
  Rat   303 QVLFTAVAALIMDRAGRKLLLALSGVIMVFSMSAFGTYFKLTQSGPSNSSHVGLLVPISAEPADV 367

  Fly   366 --WMSYLSVVATLGFVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSM 428
              .:::|:|.:...|:..||||.|.|||::.:|:|....:..|..:.||.||...|:|...|.|:
  Rat   368 HLGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSI 432

  Fly   429 KTALENY-TFLPFSVFLAIFWIFTYKKVPETKNKTFEEILALFRHNNGR 476
            ...|..| .|...:.|..:..:||...|||||.:|.|:|.|   |..||
  Rat   433 MEILRPYGAFWLTAAFCILSVLFTLTFVPETKGRTLEQITA---HFEGR 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	148/465 (32%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	158/482 (33%)
Slc2a8	NP_445946.2	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:10671487	12..13
		MFS	27..470	CDD:421695	157/484 (32%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810