Protein Alignment Glut1 and ITR1

DIOPT Version :10

• Sequence 1: NP_612073.2
• Gene: Glut1 / 38109
• FlyBaseID: FBgn0264574
• Length: 1440
• Species: Drosophila melanogaster
• Sequence 2: NP_010785.1
• Gene: ITR1 / 852108
• SGDID: S000002905
• Length: 584
• Species: Saccharomyces cerevisiae
• Alignment Length: 496
• Identity: 142/496 - (28%)
• Similarity: 237/496 - (47%)
• Gaps: 68/496 - (13%)

  Fly    11 FFLTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFI----QQLYSVAVS 71
            |.:|.:..:::.|.: |||:||.|::...:|            |.|:..:.:    :::.:.|.|
Yeast    85 FIITLTFVASISGFM-FGYDTGYISSALISI------------GTDLDHKVLTYGEKEIVTAATS 136

  Fly    72 IFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVS-HSYEMLFLGRFIIGVNCG 135
               :|.::.....|..|:.||||..|:.:|::.:.||.|    :|| |::..:.:||.|:|...|
Yeast   137 ---LGALITSIFAGTAADIFGRKRCLMGSNLMFVIGAIL----QVSAHTFWQMAVGRLIMGFGVG 194

  Fly   136 LNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAIL 200
            :.:.:.|::||||||..:||.|..:|.|.:|.|.|::...| ..:...|.||.||:||::.|..:
Yeast   195 IGSLIAPLFISEIAPKMIRGRLTVINSLWLTGGQLVAYGCG-AGLNYVNNGWRILVGLSLIPTAV 258

  Fly   201 QLILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEEMRAEERAQQSES--------- 256
            |...|...|::||| .:.|.....|.:.|:|.....|  |:|.|.:.||....::|
Yeast   259 QFTCLCFLPDTPRY-YVMKGDLARATEVLKRSYTDTS--EEIIERKVEELVTLNQSIPGKNVPEK 320

  Fly   257 -HISTMELICSPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIM 320
             ..:..||...|:....||||..:|..|||:|.|::.|:|.::|.:.|....||  .:|.:....
Yeast   321 VWNTIKELHTVPSNLRALIIGCGLQAIQQFTGWNSLMYFSGTIFETVGFKNSSA--VSIIVSGTN 383

  Fly   321 VVMTLVSIPLMDRTGRRTLHLYGLGGMFIFSIFITISF-------------LIKEMIDWMSYLSV 372
            .:.|||:...:|:.||||:.|.||.||.:..:..:|:|             ::.........:.:
Yeast   384 FIFTLVAFFSIDKIGRRTILLIGLPGMTMALVVCSIAFHFLGIKFDGAVAVVVSSGFSSWGIVII 448

  Fly   373 VATLGFVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYT- 436
            |..:.|..|:|:|.|::||. .:|||.|..|....:.|...||..:.|:...|.:|   |:|.|
Yeast   449 VFIIVFAAFYALGIGTVPWQ-QSELFPQNVRGIGTSYATATNWAGSLVIASTFLTM---LQNITP 509

  Fly   437 ------FLPFSVFLAIFWIFTYKKVPETKNKTFEEILALFR 471
                  |...|....||..|.|   ||......||:..:.:
Yeast   510 AGTFAFFAGLSCLSTIFCYFCY---PELSGLELEEVQTILK 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS_GLUT_Class1	15..461	CDD:340989	138/480 (29%)
ITR1	NP_010785.1	MFS_HMIT_like	92..533	CDD:340918	136/473 (29%)