DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and HXT3

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_010632.1	Gene:	HXT3 / 851946	SGDID:	S000002753	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	541	Identity:	148/541 - (27%)
Similarity:	248/541 - (45%)	Gaps:	73/541 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FLTYSIFSAVL--GMLQFGYNTGVINAPEKNIENFMKDV-YKDRYG---EDISEEFIQQLYSVAV 70
            ::|.||...::  |...||::||.|:       .|:... :..|:|   :|.|....:....:.|
Yeast    59 YVTVSICCVMVAFGGFVFGWDTGTIS-------GFVAQTDFLRRFGMKHKDGSYYLSKVRTGLIV 116

  Fly    71 SIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCG 135
            |||.||..:||.....:.:.:|||.||::..|:.|.| .::....::..|: .|:||.|.|:..|
Yeast   117 SIFNIGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIG-IIIQIASINKWYQ-YFIGRIISGLGVG 179

  Fly   136 LNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEG---------WPILL 191
            ....|.||.|||:||..:||.|.:..||.:|:|:.|...        ||.|         |.:.|
Yeast   180 GIAVLSPMLISEVAPKEMRGTLVSCYQLMITLGIFLGYC--------TNFGTKNYSNSVQWRVPL 236

  Fly   192 GLAICPAILQLILLPVCPESPRYLLITKQWEEEARKALRRLRASGS----VEEDIEEMRAEERAQ 252
            ||....|:..:..:...|||||||:...| .:|||.:|.::.....    :::::|.:.|.....
Yeast   237 GLCFAWALFMIGGMTFVPESPRYLVEAGQ-IDEARASLSKVNKVAPDHPFIQQELEVIEASVEEA 300

  Fly   253 QSESHISTMELIC-SPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFAT-IG 315
            ::....|..||.. .|.:....::||::|..||.:|.|..|||.|::|.:.|:::   .|.| |.
Yeast   301 RAAGSASWGELFTGKPAMFKRTMMGIMIQSLQQLTGDNYFFYYGTTVFNAVGMSD---SFETSIV 362

  Fly   316 IGAIMVVMTLVSIPLMDRTGRRTLHLYGLGGM---FIFSIFITISFLIKEMIDW----------- 366
            .|.:....|..|:..:||.|||...|||..||   ::....:.::.|      |
Yeast   363 FGVVNFFSTCCSLYTVDRFGRRNCLLYGAIGMVCCYVVYASVGVTRL------WPNGEGNGSSKG 421

  Fly   367 MSYLSVVATLGFVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTA 431
            .....:|....::..||.....|.:::.:|.|....:..||:||...||:..|::|...|.:..|
Yeast   422 AGNCMIVFACFYIFCFATTWAPIAYVVISETFPLRVKSKAMSIATAANWLWGFLIGFFTPFITGA 486

  Fly   432 LE---NYTFLPFSVFLAIFWIFTYKKVPETKNKTFEEILALFRHNNGRSMLNCTN-SLEPQSMNS 492
            :.   .|.|:...|| |.|::|.:  |||||..|.||:..::    ...:|...: |..|.|...
Yeast   487 INFYYGYVFMGCMVF-AYFYVFFF--VPETKGLTLEEVNDMY----AEGVLPWKSASWVPTSQRG 544

  Fly   493 GIEHAALMVSEEKTQHDSLFG 513
            ....|..::.:::..:..:||
Yeast   545 ANYDADALMHDDQPFYKKMFG 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	131/472 (28%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	138/489 (28%)
HXT3	NP_010632.1	Sugar_tr	65..525	CDD:395036	138/489 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13429
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.810