DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and RGT2

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_010143.1	Gene:	RGT2 / 851417	SGDID:	S000002297	Length:	763	Species:	Saccharomyces cerevisiae

Alignment Length:	520	Identity:	139/520 - (26%)
Similarity:	236/520 - (45%)	Gaps:	80/520 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IFSAVLGMLQFGYNTGVINAPEKNIENFMKDV-YKDRYGEDISEEFIQQLYSVAVSIFAIGGMLG 80
            ||.||.|.| |||:||:||:        :.|: |...|.......|.....::.||..::|...|
Yeast   104 IFVAVGGFL-FGYDTGLINS--------ITDMPYVKTYIAPNHSYFTTSQIAILVSFLSLGTFFG 159

  Fly    81 GFSGGWMANRFGRKGGLL--------LNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGLN 137
            .....::::.:|||..::        :.|.|.:|...|:          :|.:||.|.|:..|:.
Yeast   160 ALIAPYISDSYGRKPTIMFSTAVIFSIGNSLQVASGGLV----------LLIVGRVISGIGIGII 214

  Fly   138 TSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTN-----EGWPILLGLAICP 197
            :::||:|.:|.|..||||.:.:..|.|:|:|||:|..:.    .||:     ..:.|.:||....
Yeast   215 SAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVS----QGTHSKNGPSSYRIPIGLQYVW 275

  Fly   198 AILQLILLPVCPESPRYLLITKQWEEEARKALRRLRA----SGSVEEDIEEMRAEERAQQSESHI 258
            :.:..:.:...||||||.:: |....:|.|:|..||.    ...:.|::.|::|....:.|....
Yeast   276 SSILAVGMIFLPESPRYYVL-KDELNKAAKSLSFLRGLPIEDPRLLEELVEIKATYDYEASFGPS 339

  Fly   259 STMELICSPTLRPPLII----GIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAI 319
            :.::...:...||..|:    ||.:|..||.||||.:|||..:.|.::|:  :::...:....|:
Yeast   340 TLLDCFKTSENRPKQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGV--DNSYLVSFISYAV 402

  Fly   320 MVVMTLVSIPLMDRTGRRTLHLYGLGGMFIFSIFITISFLIKEMIDWMSYLSVVATLGFVVF--- 381
            .|..::..:.|:||.|||.:.|.|       .:.:.|:.|:..::......:|||:...:.|
Yeast   403 NVAFSIPGMYLVDRIGRRPVLLAG-------GVIMAIANLVIAIVGVSEGKTVVASKIMIAFICL 460

  Fly   382 ----FAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANF--------VVGIGFPSMKTALEN 434
                |:...|.:.|:::|||:..|.|....||....||:.||        :|.:|  |..:::..
Yeast   461 FIAAFSATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDVG--SHTSSMGP 523

  Fly   435 YTFLPFSVFLAIFWIFTYKKVPETKNKTFEEILALFRHNNGRSMLNCTNSLEPQSMNSGIEHAAL 499
            ..|..:.....:..|..|..|.||:..|.|||..|||        ...||:.....|..|....|
Yeast   524 KIFFIWGGLNVVAVIVVYFAVYETRGLTLEEIDELFR--------KAPNSVISSKWNKKIRKRCL 580

Fly 500 499
Yeast 581 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	123/471 (26%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	130/488 (27%)
RGT2	NP_010143.1	SP	76..555	CDD:273317	129/485 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13429
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.810