DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and GAL2

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_013182.1	Gene:	GAL2 / 850770	SGDID:	S000004071	Length:	574	Species:	Saccharomyces cerevisiae

Alignment Length:	490	Identity:	137/490 - (27%)
Similarity:	218/490 - (44%)	Gaps:	54/490 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FLTYSI--FSAVLGMLQFGYNTGVINAPEKNIENFMKDV-YKDRYG---EDISEEFIQQLYSVAV 70
            ::|.|:  .....|...||::||.|:       .|:... :..|:|   :|.:.........:.|
Yeast    68 YVTVSLLCLCVAFGGFMFGWDTGTIS-------GFVVQTDFLRRFGMKHKDGTHYLSNVRTGLIV 125

  Fly    71 SIFAIGGMLGGF---SGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGV 132
            :||.||...||.   .||.|   :|||.||.:...:.|.| .::....::..|: .|:||.|.|:
Yeast   126 AIFNIGCAFGGIILSKGGDM---YGRKKGLSIVVSVYIVG-IIIQIASINKWYQ-YFIGRIISGL 185

  Fly   133 NCGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEG---------WP 188
            ..|....|.||.||||||.:|||.|.:..||.:|.|:.|...        ||.|         |.
Yeast   186 GVGGIAVLCPMLISEIAPKHLRGTLVSCYQLMITAGIFLGYC--------TNYGTKSYSNSVQWR 242

  Fly   189 ILLGLAICPAILQLILLPVCPESPRYLLITKQWEEEARKALRRLRAS---GSVEEDIEEMRAEER 250
            :.|||....::..:..|.:.|||||||....:.|:..|...:..:.|   .:|:.:::.:.|...
Yeast   243 VPLGLCFAWSLFMIGALTLVPESPRYLCEVNKVEDAKRSIAKSNKVSPEDPAVQAELDLIMAGIE 307

  Fly   251 AQQSESHISTMELICSPT-LRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFAT- 313
            |::...:.|..||..:.| :...|::|:.:|:.||.:|.|..|||.|.:|.|.||.:   .|.|
Yeast   308 AEKLAGNASWGELFSTKTKVFQRLLMGVFVQMFQQLTGNNYFFYYGTVIFKSVGLDD---SFETS 369

  Fly   314 IGIGAIMVVMTLVSIPLMDRTGRRTLHLYGLGGMFIFSIFITISFLIKEMIDWMSYLS------- 371
            |.||.:....|..|:..::..|.|...|.|...|....:......:.:......|..|
Yeast   370 IVIGVVNFASTFFSLWTVENLGHRKCLLLGAATMMACMVIYASVGVTRLYPHGKSQPSSKGAGNC 434

  Fly   372 -VVATLGFVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENY 435
             :|.|..::..:|.....:.|:||||.|....:...||:|...||:..|::....|.:.:|:..|
Yeast   435 MIVFTCFYIFCYATTWAPVAWVITAESFPLRVKSKCMALASASNWVWGFLIAFFTPFITSAINFY 499

  Fly   436 TFLPFSVFLAIFWIFTYKKVPETKNKTFEEILALF 470
            ....|...|...:.:.:..|||||..:.|||..|:
Yeast   500 YGYVFMGCLVAMFFYVFFFVPETKGLSLEEIQELW 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	126/465 (27%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	134/480 (28%)
GAL2	NP_013182.1	Sugar_tr	74..534	CDD:278511	134/482 (28%)
GAL2	NP_013182.1	MFS	75..518	CDD:119392	126/465 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13429
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.810