DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and INT2

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_174313.1	Gene:	INT2 / 839902	AraportID:	AT1G30220	Length:	580	Species:	Arabidopsis thaliana

Alignment Length:	567	Identity:	161/567 - (28%)
Similarity:	254/567 - (44%)	Gaps:	123/567 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FFLTYS-------IFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSV 68
            |.||:.       .|||.:|.|.|||:||||:.....|.:..|.|.::.:           |..:
plant    19 FSLTWKNPYVLRLAFSAGIGGLLFGYDTGVISGALLYIRDDFKSVDRNTW-----------LQEM 72

  Fly    69 AVSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVN 133
            .||:...|.::|...|||..::.||:..:|:.:.|.:.||.:|.   .:.:..:|.:||..:|:.
plant    73 IVSMAVAGAIVGAAIGGWANDKLGRRSAILMADFLFLLGAIIMA---AAPNPSLLVVGRVFVGLG 134

  Fly   134 CGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQV--LGIEQILGTNEGWPILLGLAIC 196
            .|:.:...|:||||.:|..:||.|.:.|...:|.|..||.:  |....:.||   |..:||:|..
plant   135 VGMASMTAPLYISEASPAKIRGALVSTNGFLITGGQFLSYLINLAFTDVTGT---WRWMLGIAGI 196

  Fly   197 PAILQLILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDI----EEMRAEERAQQSESH 257
            ||:||.:|:...|||||: |..|..||||:..|||:.::..||::|    :.:..|...:.|...
plant   197 PALLQFVLMFTLPESPRW-LYRKGREEEAKAILRRIYSAEDVEQEIRALKDSVETEILEEGSSEK 260

  Fly   258 ISTMELICSPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESA----KFATIGIGA 318
            |:.::|..:.|:|..||.|:.:|:.|||.|||.|.|||.::...:|......    ...|.|:.|
plant   261 INMIKLCKAKTVRRGLIAGVGLQVFQQFVGINTVMYYSPTIVQLAGFASNRTALLLSLVTAGLNA 325

  Fly   319 IMVVMTLVSIPLMDRTGRRTLHLYGLGGMFIFSIFIT------------ISFLIKEMID------ 365
            .   .:::||..:||.||:.|.:..|.|:.|....:|            ||.|..:..:
plant   326 F---GSIISIYFIDRIGRKKLLIISLFGVIISLGILTGVFYEAATHAPAISSLETQRFNNISCPD 387

  Fly   366 --------------------------------------WMSYLSV-------------------- 372
                                                  |:|..||
plant   388 YKSAMNTNAWDCMTCLKASSPSCGYCSSPIGKEHPGACWISDDSVKDLCHNENRLWYTRGCPSNF 452

  Fly   373 --VATLG---FVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTAL 432
              .|.||   :::||:.|.|::||::.:|::....|.....||...||::|.:|...|.|:..|:
plant   453 GWFALLGLGLYIIFFSPGMGTVPWIVNSEIYPLRFRGICGGIAATANWISNLIVAQSFLSLTEAI 517

  Fly   433 -ENYTFLPFSVFLAIFWIFTYKKVPETKNKTFEEILALFRHNNGRSM 478
             .::|||.|.|...|..:|....|||||....|||..:...   |||
plant   518 GTSWTFLIFGVISVIALLFVMVCVPETKGMPMEEIEKMLER---RSM 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	147/526 (28%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	155/543 (29%)
INT2	NP_174313.1	SP	25..552	CDD:273317	153/547 (28%)
INT2	NP_174313.1	MFS	33..541	CDD:119392	147/528 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326501at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920