DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut1 and SLC2A3

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_008862.1	Gene:	SLC2A3 / 6515	HGNCID:	11007	Length:	496	Species:	Homo sapiens

Alignment Length:	487	Identity:	240/487 - (49%)
Similarity:	322/487 - (66%)	Gaps:	12/487 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PGLTFFLTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVS 71
            |.|.|.:|.    |.:|..||||||||||||||.|:.|:.....|:.....||..:..|:|::|:
Human     8 PALIFAITV----ATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVA 68

  Fly    72 IFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGL 136
            ||::|||:|.||.|...|||||:..:|:.|:|.:.|.|.||..||:.|.|||.|||.:||:.|||
Human    69 IFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGL 133

  Fly   137 NTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAILQ 201
            .|..|||||.||:|..|||..||:|||.:.||:|::|:.|:|.|||:.|.||:|||..|.|||||
Human   134 CTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQ 198

  Fly   202 LILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEEMRAEERAQQSESHISTMELICS 266
            ...||.||||||:|||.::.||.|::.|:||..:..|.:||:||:.|......|..::.:||...
Human   199 SAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRV 263

  Fly   267 PTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSIPLM 331
            .:.|.|:||.||:|||||.|||||||||||.:|..:|:.|..  :||||.|.:..:.|:||:.|:
Human   264 SSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPI--YATIGAGVVNTIFTVVSLFLV 326

  Fly   332 DRTGRRTLHLYGLGGMFIFSIFITISFLIKEMIDWMSYLSVVATLGFVVFFAVGPGSIPWMITAE 396
            :|.||||||:.|||||...|..:|:|.|:|:..:.||::.:.|.|.||.||.:|||.|||.|.||
Human   327 ERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAE 391

  Fly   397 LFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVFLAIFWIFTYKKVPETKNK 461
            ||||||||:|||:|...||.:||:||:.|||....|..|.|:.|:.||..|..||:.|||||:.:
Human   392 LFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGR 456

  Fly   462 TFEEILALFR------HNNGRSMLNCTNSLEP 487
            |||:|...|.      ..:|:..:...||:||
Human   457 TFEDITRAFEGQAHGADRSGKDGVMEMNSIEP 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	220/434 (51%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	230/451 (51%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	228/449 (51%)
		Important for selectivity against fructose. /evidence=ECO:0000269\|PubMed:26176916	277..279		1/1 (100%)
		Monosaccharide binding. /evidence=ECO:0000269\|PubMed:26176916	280..286		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	484	1.000	Domainoid score	I399
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74302
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	1	1.000	-	-		otm41650
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.820