DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut1 and SLC2A2

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_000331.1	Gene:	SLC2A2 / 6514	HGNCID:	11006	Length:	524	Species:	Homo sapiens

Alignment Length:	501	Identity:	216/501 - (43%)
Similarity:	316/501 - (63%)	Gaps:	36/501 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LTFFLTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDV----YKDR----------------- 52
            :|..|.:::.:||||..||||:.||||||::.|.:..:.|    ..||
Human     6 VTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVINSTDELPTI 70

  Fly    53 ----------YGED---ISEEFIQQLYSVAVSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLG 104
                      :.|:   .:.:.|..|:|::||.||:|||...|.|||:.:..||...:|:.|:|.
Human    71 SYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVANILS 135

  Fly   105 IAGACLMGFTKVSHSYEMLFLGRFIIGVNCGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGL 169
            :.||.||||:|:..|:.::..||.|.|:.|||.:.||||||.||||..|||.|||.:|||:..|:
Human   136 LVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGI 200

  Fly   170 LLSQVLGIEQILGTNEGWPILLGLAICPAILQLILLPVCPESPRYLLITKQWEEEARKALRRLRA 234
            |:||::|:|.|||..:.|.|||||:...||||.:||..||||||||.|....|.:|:::|:|||.
Human   201 LISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRG 265

  Fly   235 SGSVEEDIEEMRAEERAQQSESHISTMELICSPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLF 299
            ...|.:||.|||.|.....||..:|.::|..:.:.|.|:::.:::.::|||||||.:||||||:|
Human   266 YDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIF 330

  Fly   300 MSSGLTEESAKFATIGIGAIMVVMTLVSIPLMDRTGRRTLHLYGLGGMFIFSIFITISFLIKEMI 364
            .::|:::  ..:||||:||:.:|.|.||:.|:::.|||:|.|.|:.|||:.:||:::..::....
Human   331 QTAGISK--PVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKF 393

  Fly   365 DWMSYLSVVATLGFVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMK 429
            .||||:|::|...||.||.:|||.|||.:.||.|||||||:|:|||...||..||:|.:.|..:.
Human   394 SWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIA 458

  Fly   430 TALENYTFLPFSVFLAIFWIFTYKKVPETKNKTFEEILALFRHNNG 475
            .....|.|..|:..|..|.:||:.||||||.|:||||.|.|:..:|
Human   459 DFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIAAEFQKKSG 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	199/468 (43%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	212/485 (44%)
SLC2A2	NP_000331.1	Sugar_tr	14..499	CDD:278511	212/486 (44%)
		MFS	98..485	CDD:119392	180/388 (46%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	314..320		5/5 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	484	1.000	Domainoid score	I399
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	1	1.000	-	-		otm41650
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.720