DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and slc2a11a

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	XP_009300884.1	Gene:	slc2a11a / 560358	ZFINID:	ZDB-GENE-080723-20	Length:	555	Species:	Danio rerio

Alignment Length:	470	Identity:	144/470 - (30%)
Similarity:	264/470 - (56%)	Gaps:	1/470 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GLTFFLTYSIFSAVL-GMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVS 71
            |.::.|...:.||.: |.||:|||..::|||...|:||:.:.:::|:|..:....:..:::..||
Zfish    61 GHSYTLVLMVTSAAIGGTLQYGYNLAIMNAPTIFIQNFVNETFQERWGIQLGVYEVTLIWTFIVS 125

  Fly    72 IFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGL 136
            ||::||:.|....|.|:.|.|||..||||||..::.:.|...::.:.|:||:.:.||::|:|.|:
Zfish   126 IFSLGGLTGALIAGPMSVRLGRKKTLLLNNVFLLSSSLLALLSRTAKSFEMIIISRFLVGINAGI 190

  Fly   137 NTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAILQ 201
            :.::.|||..|.||.:|||.:...:.:..:.||:|.||:.:.::||:...|..||.....|..:|
Zfish   191 SMNVQPMYFGESAPKHLRGAVSLSSAVFTSFGLVLGQVVSLRELLGSEPYWQYLLASNAIPGFIQ 255

  Fly   202 LILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEEMRAEERAQQSESHISTMELICS 266
            |:.||..||||||||...:.:|....||:|||......|:::|:..|:...:|:......:|:..
Zfish   256 LLTLPWFPESPRYLLFDCKDKEACLSALKRLRGCEVRREELDELLQEQNEIKSDRAKQPWDLLTD 320

  Fly   267 PTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSIPLM 331
            .::|..||...|:..:.|..|.:::::|::.:|..:|::....::.|||.|.......::...|:
Zfish   321 RSVRWQLISVAVLSSAMQLCGNDSIYFYASYVFQEAGISAGQIQYVTIGTGMCEFTACILCNLLI 385

  Fly   332 DRTGRRTLHLYGLGGMFIFSIFITISFLIKEMIDWMSYLSVVATLGFVVFFAVGPGSIPWMITAE 396
            :|.||:.:.:.|...|..:::..|::..::.::.||.|||:.....:::.|.:||..:..::..|
Zfish   386 ERLGRKLMLMGGYVLMTGWAVVFTVALSLENIVTWMPYLSMTCIFTYILSFGMGPAGVSVILPTE 450

  Fly   397 LFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVFLAIFWIFTYKKVPETKNK 461
            :|:|..||:|...|..:.|:..|::|:.||.:.:.|..|.|:||.....:...:.:..:||||.|
Zfish   451 IFNQTARPAACMTAGFLMWLNLFIIGMIFPFLVSGLGQYCFVPFGTVCLVTATYIHMVLPETKGK 515

  Fly   462 TFEEILALFRHNNGR 476
            |...|...|...|.|
Zfish   516 TLPMITKEFYKLNYR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	132/435 (30%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	139/452 (31%)
slc2a11a	XP_009300884.1	Sugar_tr	69..524	CDD:278511	139/454 (31%)
slc2a11a	XP_009300884.1	MFS	122..508	CDD:119392	116/385 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920