DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and Slc2a8

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_062361.1	Gene:	Slc2a8 / 56017	MGIID:	1860103	Length:	477	Species:	Mus musculus

Alignment Length:	499	Identity:	168/499 - (33%)
Similarity:	244/499 - (48%)	Gaps:	74/499 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GLTFFLTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVSI 72
            |...||  :.|:|.||.|.||:..|..:....::........  |.|::.:..|        .::
Mouse    23 GRRVFL--ASFAAALGPLSFGFALGYSSPAIPSLRRTAPPAL--RLGDNAASWF--------GAV 75

  Fly    73 FAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGLN 137
            ..:|...||..|||:.:|.|||..|||..|..:.|..::   ..:....||..||.:.|:.||:.
Mouse    76 VTLGAAAGGILGGWLLDRAGRKLSLLLCTVPFVTGFAVI---TAARDVWMLLGGRLLTGLACGVA 137

  Fly   138 TSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLG--IEQILGTNEGWPILLGLAICPAIL 200
            :.:.|:||||||...:||.||:..||.|..|:||:.|.|  :|        |..|..|...|..|
Mouse   138 SLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLE--------WRWLAVLGCVPPTL 194

  Fly   201 QLILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEE--MRAEERAQQSESHISTMEL 263
            .|:|:...||:||:||...|: :||..|||.|..|   ||..||  :.||.:..|       :.|
Mouse   195 MLLLMCYMPETPRFLLTQHQY-QEAMAALRFLWGS---EEGWEEPPVGAEHQGFQ-------LAL 248

  Fly   264 ICSPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKF-----ATIGIGAIMVVM 323
            :..|.:..||||||.:.:.||.||:||:.:|:.|:|       |.|||     |::.:|.|.|:.
Mouse   249 LRRPGIYKPLIIGISLMVFQQLSGVNAIMFYANSIF-------EEAKFKDSSLASVTVGIIQVLF 306

  Fly   324 TLVSIPLMDRTGRR-TLHLYGLGGMFIFSIFITISFLIK----------------EMID---WMS 368
            |.|:..:|||.||| .|.|.|:..:|..|.|.|...|.:                |.:|   .::
Mouse   307 TAVAALIMDRAGRRLLLALSGVIMVFSMSAFGTYFKLTQSLPSNSSHVGLVPIAAEPVDVQVGLA 371

  Fly   369 YLSVVATLGFVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALE 433
            :|:|.:...|:..||||.|.|||::.:|:|....:..|..|.||.||...|:|...|.|:...|.
Mouse   372 WLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWFMAFLVTKEFSSVMEMLR 436

  Fly   434 NY-TFLPFSVFLAIFWIFTYKKVPETKNKTFEEILALFRHNNGR 476
            .| .|...:.|.|:..:||...|||||.:|.|::.|   |..||
Mouse   437 PYGAFWLTAAFCALSVLFTLTVVPETKGRTLEQVTA---HFEGR 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	153/464 (33%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	162/481 (34%)
Slc2a8	NP_062361.1	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:16723738	12..13
		Sugar_tr	29..474	CDD:278511	162/486 (33%)
		MFS	31..459	CDD:119392	154/466 (33%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810