DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and slc2a1a

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_001034897.1	Gene:	slc2a1a / 555778	ZFINID:	ZDB-GENE-030131-3158	Length:	488	Species:	Danio rerio

Alignment Length:	459	Identity:	233/459 - (50%)
Similarity:	322/459 - (70%)	Gaps:	2/459 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVSIFAIGG 77
            |..::.:||:|.|||||||||||||:|.||.|..:.:.:||.|.|....:..|:||:|:||::||
Zfish    12 LMMAVGTAVIGSLQFGYNTGVINAPQKIIEGFYNETWHNRYSEYIPPTTLTTLWSVSVAIFSVGG 76

  Fly    78 MLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGLNTSLVP 142
            :||.||.|...|||||:..:|:.|:|....|..|||:|::.|:|||.:||||:|:..||:|..||
Zfish    77 ILGSFSVGLFVNRFGRRNSMLIANILAFIAAAFMGFSKLAESWEMLIIGRFIVGLYSGLSTGFVP 141

  Fly   143 MYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAILQLILLPV 207
            ||:.||||.:|||.|||::||.:.:|:|::|:.||::|:|:...||.:||....||:||..|||.
Zfish   142 MYVGEIAPTSLRGALGTLHQLGIVIGILMAQIFGIKEIMGSPTLWPFMLGFTFIPAVLQCALLPF 206

  Fly   208 CPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEEMRAEERAQQSESHISTMELICSPTLRPP 272
            ||||||||||.:..|.:|:..|::||.:..|..|::|||.|.|....|..::..||..|...|.|
Zfish   207 CPESPRYLLINQNEEAKAKSVLKKLRGTDDVGADMQEMRDESRQMMREKTVTIPELFRSSLYRQP 271

  Fly   273 LIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSIPLMDRTGRR 337
            :.|.|::|||||||||||||||||.:|..:|::|  ..:||||.||:....|:||:.:::|.|||
Zfish   272 IFIAIMLQLSQQFSGINAVFYYSTGIFEKAGVSE--PVYATIGAGAVNTAFTVVSLFIVERVGRR 334

  Fly   338 TLHLYGLGGMFIFSIFITISFLIKEMIDWMSYLSVVATLGFVVFFAVGPGSIPWMITAELFSQGP 402
            :|||.||.||.:.|:.:||:..:...::||||:|:||...||.||.:|||.|||.|.||||||||
Zfish   335 SLHLVGLMGMAVSSVLMTIAMALLTKVEWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGP 399

  Fly   403 RPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVFLAIFWIFTYKKVPETKNKTFEEIL 467
            ||||.|:|...||.|||:||:.|..::.....|.|:.|:|.|.||::|||.||||||.::||||.
Zfish   400 RPSAFAVAGFSNWFANFLVGMCFQYVEELTGPYVFIIFTVLLLIFFVFTYFKVPETKGRSFEEIT 464

  Fly   468 ALFR 471
            |.||
Zfish   465 ASFR 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	217/434 (50%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	230/451 (51%)
slc2a1a	NP_001034897.1	Sugar_tr	18..467	CDD:278511	230/450 (51%)
slc2a1a	NP_001034897.1	MFS	62..450	CDD:119392	194/389 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	477	1.000	Domainoid score	I404
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	1	1.000	-	-		otm25868
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.720