DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and sut3

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_524731.1	Gene:	sut3 / 44268	FlyBaseID:	FBgn0028561	Length:	476	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	151/473 - (31%)
Similarity:	243/473 - (51%)	Gaps:	14/473 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GLTFFLTYSIFSAVLG-MLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVS 71
            |.|..|........:| ::..||..||:|||...|.:::.:...:||...:.:..:..:.|..||
  Fly     7 GWTCLLVLICVCITVGTVIPVGYAFGVMNAPSAFIRSWIMESVLERYSSRLGDSQMTIIMSTVVS 71

  Fly    72 IFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGL 136
            ||.||||||.......:.|.||:|.|.|:.:|.:.......|.::::|.|||.|||.|.|:...|
  Fly    72 IFLIGGMLGAPFAPIFSARLGRRGILTLSGLLLLVSCICQLFCRMANSIEMLLLGRLIGGLAAAL 136

  Fly   137 NTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAILQ 201
            ..:..|||:.|:||..|.|.:|....:.:|.|::|.||...:.:|||.:.||..|..:   ||..
  Fly   137 IYATQPMYLVELAPAELSGSVGVFTCIGLTGGIVLGQVFSFDFLLGTEKLWPYALSGS---AIFV 198

  Fly   202 LI-LLPV--CPESPRYLLITKQWEEEARKALRRLRA-SGSVEEDIEEMRAEERAQQSESHISTME 262
            || |.|:  .|||||:|: ::...|:||..|.|||. .|.|..::.|.   |.:...|..::..:
  Fly   199 LIGLAPIFWFPESPRFLM-SQGRREKARVTLMRLRRDEGRVNAEMAEF---EVSSTDEGQVTMKQ 259

  Fly   263 LICSPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVS 327
            ::|:..|:.||.|.......||.|||:|:::||..:|..||.|...|.:....:|.:..:..|:.
  Fly   260 VLCNSKLKLPLFIVCSFHFVQQMSGISAIWFYSIEIFTQSGFTAAVAMWLNFALGLLNFISALMG 324

  Fly   328 IPLMDRTGRRTLHLYGLGGMFIFSIFITISFLIKEMIDWMSYLSVVATLGFVVFFAVGPGSIPWM 392
            ..||....||.:.........||.:.:.:...:...|...|:..:.....:::.|.:|.|..|:.
  Fly   325 PWLMRSFNRRLMMTISCLCSAIFLVLLVVGLELMSTIHEFSFTCIAFLSLYIITFNMGLGPTPYF 389

  Fly   393 ITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVFLAIFWIFTYKKVPE 457
            |.:|:|....||||||:....||:||||:.:.||::.:|...:.||...||.|..::.||:.:||
  Fly   390 IGSEIFETASRPSAMALGSFFNWLANFVLNMIFPTLNSATGPFVFLLCVVFCAYGFLLTYRYLPE 454

  Fly   458 TKNKTFEEILALFRHNNG 475
            |:|:..:::..|.  .||
  Fly   455 TRNRDAKDVAQLM--ENG 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	139/439 (32%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	145/456 (32%)
sut3	NP_524731.1	Sugar_tr	28..466	CDD:278511	144/444 (32%)
sut3	NP_524731.1	MFS	66..451	CDD:119392	130/391 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I126
eggNOG	1	0.900	-	-		E2759_KOG0569
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	1	1.000	-	-		mtm13429
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.920