DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and slc2a15a

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_001156013.1	Gene:	slc2a15a / 394245	ZFINID:	ZDB-GENE-060531-109	Length:	522	Species:	Danio rerio

Alignment Length:	467	Identity:	178/467 - (38%)
Similarity:	280/467 - (59%)	Gaps:	5/467 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LTFFLTYSIFSAVL-----GMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSV 68
            :|..||.|:.:...     ..:.:|||..|:|:|...|:.|.......|.|..::||.:..:||:
Zfish    13 ITSHLTSSLLAVAFLTSFGSSMLYGYNLAVVNSPAGYIKEFYNRTVVSRNGTGLNEEALTLMYSL 77

  Fly    69 AVSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVN 133
            .||:|||||::|....|.:..||||||.::.:..|....|.||||:::..|.||:..|||:.|::
Zfish    78 TVSVFAIGGLIGSLMVGTLVTRFGRKGTVVNSTALVFLAATLMGFSRICSSPEMVIFGRFVTGIH 142

  Fly   134 CGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPA 198
            .|::.|:||||:.||||.||||.||.:..:.:..|:.|:||||:.::||..|.||:.|.|.:.|.
Zfish   143 SGISLSVVPMYLGEIAPKNLRGFLGLMPSIFICAGVFLAQVLGLHELLGKEEHWPLFLSLVVVPT 207

  Fly   199 ILQLILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEEMRAEERAQQSESHISTMEL 263
            .:||:|||..|||||||||.|........||:..||..:::.:||||:.|:|:..|...||..:|
Zfish   208 FIQLMLLPWFPESPRYLLIEKHNVHATITALKWYRAKCNIQAEIEEMQEEQRSLSSVDTISVWQL 272

  Fly   264 ICSPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSI 328
            |...|:|..::..:|:.:..|.|||:|:::|:..:|.::|:.....::.|:|.|||.:|..|:..
Zfish   273 ILDHTVRWQVLSVVVINIGMQLSGIDAIWFYTNDIFQNAGIPAPEIQYTTVGTGAIEIVAGLIGC 337

  Fly   329 PLMDRTGRRTLHLYGLGGMFIFSIFITISFLIKEMIDWMSYLSVVATLGFVVFFAVGPGSIPWMI 393
            ..::|.|||.|.:.|.|.|.:....||:|.:::..:.:|.|:||...:|.:..|.:||..:|::|
Zfish   338 FTIERLGRRPLIIGGFGVMGMCCAGITLSLILQTHVPFMKYVSVGCVVGIIAGFCIGPAGVPFLI 402

  Fly   394 TAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVFLAIFWIFTYKKVPET 458
            |||||.|..||:|..:...:|||:||.:|..||.::.:..:|.:|.|........|:.|..:|||
Zfish   403 TAELFKQSHRPAAYTVGGSLNWMSNFTIGFIFPFLQMSAGSYCYLVFCAVCLSVAIYVYIIIPET 467

  Fly   459 KNKTFEEILALF 470
            |||||.||..:|
Zfish   468 KNKTFVEISQMF 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	162/439 (37%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	173/456 (38%)
slc2a15a	NP_001156013.1	Sugar_tr	24..479	CDD:278511	173/454 (38%)
slc2a15a	NP_001156013.1	MFS	74..464	CDD:119392	151/389 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920