DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and slc2a8

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_997963.1	Gene:	slc2a8 / 373140	ZFINID:	ZDB-GENE-030829-25	Length:	498	Species:	Danio rerio

Alignment Length:	493	Identity:	156/493 - (31%)
Similarity:	240/493 - (48%)	Gaps:	62/493 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GLTFFLTYSIFSAVLGMLQFGYNTGVIN--APEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAV 70
            |..|..|   |:||||.|.||:..|..:  .||.            |..:|:..:...:..|...
Zfish    34 GKLFIAT---FAAVLGPLSFGFVLGYSSPAIPEL------------RRIQDLRLQLSVEEASWFG 83

  Fly    71 SIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKV--SHSYEMLFLGRFIIGVN 133
            |:..||..|||..|||:..|.|||..|:.     .|...:.|||.:  :.::.|.::||.:.|:.
Zfish    84 SVVTIGAALGGLLGGWIVERIGRKLSLMF-----CAIPFIFGFTTIIAAQNHWMFYVGRVLTGLA 143

  Fly   134 CGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPA 198
            .|:.:.:||:||||:|...:||.||:..||.|.:|::.:.|.|:..      .|..|...:..|.
Zfish   144 SGVTSLVVPLYISEMAHERVRGTLGSCVQLMVVIGIMGAYVTGLFL------DWRWLAVASSIPP 202

  Fly   199 ILQLILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEEMRAEERAQQSESHISTMEL 263
            .|.|:.:...||:||:||...: ..||..|||.||...:..| .|..|.|:..:..|...|..:|
Zfish   203 TLMLLSMCFMPETPRFLLCQGK-RREAEDALRFLRGPDAPAE-WECARIEDAYKNEEQSFSLGDL 265

  Fly   264 ICSPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSI 328
             ..|.:..||.||::|.|.|||:||||:.:|:.::|..:..  :|:..||:.:.|..||.|.::.
Zfish   266 -KDPGVYKPLGIGVMMMLLQQFTGINAIMFYAETIFEQAHF--KSSDVATVIVAATQVVFTAIAA 327

  Fly   329 PLMDRTGRRTLHLYGLGGMF------IFSIFITISFLIKEMIDWMSYLS---------------- 371
            .:||:.||:.|.:  |.|:.      :|.::..::.:........|.|:
Zfish   328 LIMDKAGRKVLLI--LSGVVMCVSEAVFGVYFKLTVMKPNNSSMTSVLTDTHGLLEDQPSADLAW 390

  Fly   372 -VVATLG-FVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALEN 434
             .|.::| |:..||:|.|..||::.:|:|....|....|:.||.||...|:|...|.::..||.:
Zfish   391 LAVGSMGFFIAGFAIGWGPTPWLVMSEIFPTRVRGLGSALCVLTNWTCAFIVTKTFQNLMDALSS 455

  Fly   435 Y-TFLPFSVFLAIFWIFTYKKVPETKNKTFEEILALFR 471
            . ||..||...|...:||...|||||.||.|||.|.|:
Zfish   456 AGTFWMFSALCASNVVFTAFFVPETKGKTLEEIQAGFK 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	140/463 (30%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	152/480 (32%)
slc2a8	NP_997963.1	Sugar_tr	39..492	CDD:278511	153/485 (32%)
slc2a8	NP_997963.1	MFS	40..477	CDD:119392	142/469 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810