DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and Tret1-2

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster

Alignment Length:	490	Identity:	136/490 - (27%)
Similarity:	233/490 - (47%)	Gaps:	46/490 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVSIFAIGG 77
            |:.|:.|.|:|.:....:..:::..::.|.:|  :|.||. |..:.            .|..:..
  Fly    33 LSVSLCSLVVGFVSAYTSPALVSMTDRTITSF--EVTKDA-GSWVG------------GIMPLAA 82

  Fly    78 MLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGLNTSLVP 142
            :.||.:||.:....||:..:|...|..|..:.|:.   .:.:..|:..|||:.|...|:.:..:|
  Fly    83 LAGGITGGPLIEYLGRRSTILATAVPFIVSSLLIA---CAVNVIMILCGRFLTGFCVGIASLSLP 144

  Fly   143 MYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAILQLILLPV 207
            :|:.|.....:||.||.:......:|:|:..|      .|:...|.:|..|.....:..|||:.:
  Fly   145 VYLGETLQPEVRGTLGLLPTALGNIGILVCYV------AGSFMNWSMLAFLGAALPVPFLILMII 203

  Fly   208 CPESPRYLLITKQWEEEARKALRRLRA-SGSVEEDIEE-MRAEERAQQSESHISTMELICSPTLR 270
            .||:||: .:.:..||.|||||:.||. ...||.:::| |:::..|.:..:..:.:||.....|:
  Fly   204 IPETPRW-FVNRGQEERARKALKWLRGKEADVEPELKELMQSQADADRQATQNTCLELFKRNNLK 267

  Fly   271 PPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSIPLMDRTG 335
             ||.|.:.:...|||||||||.:|:..:|..:|.|.:| ..:||.:|.:....|.:.|.|:||.|
  Fly   268 -PLSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDS-NLSTIIVGVVNFFATFMGIILIDRLG 330

  Fly   336 RRTLHLYGLGGMFIFSIFITIS-----FLIKEMIDWMSYLSVVATLGFVVF---FAVGPGSIPWM 392
            |:.| ||    :...::.:|:|     |..|.....:|:|..:....||::   |::|.|.|||:
  Fly   331 RKIL-LY----VSDIAMIVTLSILGGFFYCKAHGPDVSHLGWLPLTCFVIYILGFSLGFGPIPWL 390

  Fly   393 ITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENY-TFLPFSVFLAIFWIFTYKKVP 456
            :..|:.....|..|.::....||...|||...|..:..|:..: .|..|.....:...|....||
  Fly   391 MMGEILPAKIRGPAASVVTAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICIVGLFFVIIFVP 455

  Fly   457 ETKNKTFEEILALFRHNNGRSMLNCTNSLEPQSMN 491
            ||:.|:.|||   .|...||..::...:::|...|
  Fly   456 ETRGKSLEEI---ERKMMGRVPMSSVVNIKPFPFN 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	121/445 (27%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	129/462 (28%)
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	131/468 (28%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	123/452 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
	3	2.810