DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and sut1

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_523658.1	Gene:	sut1 / 35774	FlyBaseID:	FBgn0028563	Length:	507	Species:	Drosophila melanogaster

Alignment Length:	459	Identity:	166/459 - (36%)
Similarity:	257/459 - (55%)	Gaps:	23/459 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVSIFAIGGMLGGFSGGWM 87
            |.:..||..||||||.|.::.:......|.||.::|...:..|:|..||:|.:||.:|...|...
  Fly    50 GAVSTGYCIGVINAPSKLMKVWCNQTLHDTYGSNLSAGGLDLLWSCVVSVFLVGGAIGSLGGAGA 114

  Fly    88 ANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGLNTSLVPMYISEIAPLN 152
            ||:||||...|:...|...||.|..|.:.:.|.|||.:|||::|:..||.|:.:|||:||:||:.
  Fly   115 ANKFGRKACFLICGALFTVGAVLFFFCRAASSVEMLVIGRFVVGLASGLVTATLPMYLSEVAPMA 179

  Fly   153 LRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAILQLILLPVC-------PE 210
            |||.||....:.||.|:::.||..:..:.||.:.|...|     .|.:.|||  ||       ||
  Fly   180 LRGTLGVFIAVGVTGGVVVGQVCSLANVFGTEDLWHYAL-----TAYMFLIL--VCYLPSYLFPE 237

  Fly   211 SPRYLLITKQWEEEARKALRRLRASGSVE---EDIEEMRAEERAQQSESHISTMELICSPTLRPP 272
            ||::|.|.|.....|::.|:|||...:.|   :::.||.||..|:...|  |..:::..|.|..|
  Fly   238 SPKFLYIVKGNRAAAKRELQRLRGKDAEELIAQEMAEMEAESNAKVQTS--SFCDVLRDPRLTLP 300

  Fly   273 LIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSIPLMDRTGRR 337
            |||.......||.|||||:||||.|:|..:||:...|::|.:|.|.:.:.::|:...||.:..||
  Fly   301 LIIVCCFHGGQQLSGINAIFYYSVSIFEKAGLSTVDAQWANLGAGCLNLAVSLLGPWLMAKCNRR 365

  Fly   338 TLHLY--GLGGMFIFSIFITISFLIKEMIDWMSYLSVVATLGFVVFFAVGPGSIPWMITAELFSQ 400
            ||.::  .|..:|:|:|...:.::  :.:.|.:...:|..:|::.|:..|.|.||:.|.||||..
  Fly   366 TLMMFSCALCSVFLFTIAFVLFYI--DQVSWFAIACIVCIMGYIFFYQFGLGPIPYFIGAELFEV 428

  Fly   401 GPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVFLAIFWIFTYKKVPETKNKTFEE 465
            .||..||::..|.:|..||::||.||.::.|...:.|||||:...:.::.|...:|||:.:...|
  Fly   429 APRSVAMSMGSLASWTCNFIIGISFPLLQNAWGAFVFLPFSITCVLLFLLTKFYLPETRGRDPSE 493

  Fly   466 ILAL 469
            :..|
  Fly   494 VAPL 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	160/440 (36%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	166/459 (36%)
sut1	NP_523658.1	Sugar_tr	55..497	CDD:278511	164/452 (36%)
sut1	NP_523658.1	MFS	96..482	CDD:119392	145/396 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I126
eggNOG	1	0.900	-	-		E2759_KOG0569
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	1	1.000	-	-		mtm13429
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.920