DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and slc2a2

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_001036186.1	Gene:	slc2a2 / 322493	ZFINID:	ZDB-GENE-030131-1213	Length:	504	Species:	Danio rerio

Alignment Length:	480	Identity:	216/480 - (45%)
Similarity:	314/480 - (65%)	Gaps:	15/480 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LTFFLTYSIFSAVLGMLQFGYNTGVINAPEKNIEN--------FMKDVYKDRYG-----EDISEE 60
            ||..|..::|:|.||.||.||:.||||||:|.||.        :.:|:.:...|     |..::.
Zfish     5 LTGTLALAVFTAALGSLQMGYSLGVINAPQKVIERHYARSLGVYNEDLARSEGGNGTEHEKPTDP 69

  Fly    61 FIQQLYSVAVSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFL 125
            .:...:|::|:||::||||..|...::.:..||..|:|..|||.|....|||..|:...:.|:..
Zfish    70 SVVMYWSLSVAIFSVGGMLSSFLVSFVGDFRGRIKGMLAINVLAITAGLLMGLAKMGTPHLMVIA 134

  Fly   126 GRFIIGVNCGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPIL 190
            ||.|:|:.|||::.|||:||.||:|:..||.:|.::|||:.:|:|:|||:|::.:||.:..|.||
Zfish   135 GRAIMGLYCGLSSGLVPLYIGEISPVKYRGAMGALHQLAIVIGILISQVIGLDFLLGNDYMWHIL 199

  Fly   191 LGLAICPAILQLILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEEMRAEERAQQSE 255
            |||:..|||||.:||.|||||||||.|.:...|:|.|:|:||:......:||.||:||:.....|
Zfish   200 LGLSGAPAILQSLLLLVCPESPRYLYIKQGKVEDACKSLKRLKGDYDTSKDIAEMKAEKEEAMKE 264

  Fly   256 SHISTMELICSPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIM 320
            :.:|.:.|:.|...|..|.:.::|..|||||||||:||||||:|.::|:.:  ..:||||:|.:.
Zfish   265 AKMSILRLLRSSVYRQQLFVALMMHFSQQFSGINAIFYYSTSIFQTAGVGQ--PVYATIGVGVVN 327

  Fly   321 VVMTLVSIPLMDRTGRRTLHLYGLGGMFIFSIFITISFLIKEMIDWMSYLSVVATLGFVVFFAVG 385
            ::.||||:.::||.|||||.|.|||||...::.:|:....:....||||:|:||...||.||.:|
Zfish   328 IIFTLVSVLMVDRAGRRTLTLVGLGGMCCCAVAMTVGLAFQGAYSWMSYVSMVAIFMFVSFFEIG 392

  Fly   386 PGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVFLAIFWIF 450
            ||.|||.|.||:|||||||:|:|:|...||..||:||:.||.:.:...:|.|:.|:|.|..|.:|
Zfish   393 PGPIPWFIVAEIFSQGPRPAAIALAGFCNWTCNFIVGMVFPYLVSLCGSYVFIVFAVLLFGFTLF 457

  Fly   451 TYKKVPETKNKTFEEILALFRHNNG 475
            .|.:|||||.||||||.|:|...:|
Zfish   458 IYFRVPETKGKTFEEIAAVFHRKHG 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	198/447 (44%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	211/464 (45%)
slc2a2	NP_001036186.1	Sugar_tr	12..477	CDD:278511	211/466 (45%)
slc2a2	NP_001036186.1	MFS	76..462	CDD:119392	179/387 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	1	1.000	-	-		otm25868
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.720