DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut1 and ght2

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_596425.1	Gene:	ght2 / 2539977	PomBaseID:	SPBC4B4.08	Length:	531	Species:	Schizosaccharomyces pombe

Alignment Length:	553	Identity:	136/553 - (24%)
Similarity:	236/553 - (42%)	Gaps:	89/553 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GLTFFLTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVA--- 69
            |..|.|...||.::.|.: ||.:||.|.. ..::.:| ::.|.||| :.|:::     ||::
pombe     6 GKNFTLVMLIFVSMAGWM-FGADTGSIGG-VTSMRDF-RERYADRY-DPITDQ-----YSLSSAR 61

  Fly    70 ----VSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGAC-------LMGFTKVSHSYEML 123
                ..:..:|.:.|......:|:|||::        |.|.|.|       ::..|.|. |:..:
pombe    62 QGLLTGMVNVGSLFGCIISSPIADRFGKR--------LSIIGFCAVYIIGIIVQVTAVP-SWVQI 117

  Fly   124 FLGRFIIGVNCGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNE--- 185
            .:.:...|:..|..:.|.|.|.||.||.::||.:....||.||.|:.::..:.    :||::
pombe   118 MVAKIWTGIGIGALSVLAPGYQSETAPPSIRGTVVVTYQLFVTGGIFIAACIN----MGTHKLHK 178

  Fly   186 --GWPILLGLAICPAILQLILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEEMRAE 248
              .|.:.:|:.:...|:.:|.:...|||||||:...:.||    |:|.|..|..:..|.||::.|
pombe   179 TAQWRVSIGINLLWGIITMIGILFLPESPRYLIQVGKDEE----AVRVLSESAELFPDSEEVQNE 239

  Fly   249 ERAQQSESHISTMELICS------PTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEE 307
            ....:|..........||      ..:|....:|:.:...||.:|.|..|||..|:...:|:  .
pombe   240 YHRLKSSIDEEFAGGPCSWASIFGKDIRYRTFLGMFVMSLQQLTGNNYFFYYGFSVMQGAGI--N 302

  Fly   308 SAKFATIGIGAIMVVMTLVSIPLMDRTGRRTLHLYGLGGMFIFSIFITISFLIKEMIDWM----- 367
            |...:.:.:.|:....|...:.:::|.|||       ..:.|..|:.:|.|.|...:...
pombe   303 SPYLSAMILDAVNFGCTFGGMYVLERFGRR-------NPLIIGGIWQSICFFIYSAVGSRALYHK 360

  Fly   368 ---------SYLSVVATLGFVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGI 423
                     :.:.|:|.| |:..||.......::|..|.:....|....|:|...||:.||::..
pombe   361 NGTSNTRAGAVMIVMACL-FIFGFAQTWAPAAYVIVGESYPVRYRSKCAAVATASNWLWNFLISF 424

  Fly   424 GFPSMKTAL---ENYTFLPFSVFLAIFWIFTYKKVPETKNKTFEEILALFRH-----NNGRSMLN 480
            ..|.::.::   ..|.|...::..||. ||.:.|  |||..|.|||..|:..     .:|...||
pombe   425 FTPFIQASIGFKYGYVFASCNLTGAIV-IFLFAK--ETKGLTLEEINELYMSVIKPWESGNFKLN 486

  Fly   481 CTNSL---EPQSMNSGIEHAALMVSEEKTQHDS 510
            .:...   :.:|...|....::...|..:..||
pombe   487 YSEQKKVEKEKSRKGGARGESVEYVERASNTDS 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	116/476 (24%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	123/493 (25%)
ght2	NP_596425.1	MFS	14..456	CDD:119392	116/478 (24%)
ght2	NP_596425.1	Sugar_tr	15..471	CDD:278511	124/494 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	3	2.810