DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and ght4

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_595064.1	Gene:	ght4 / 2539710	PomBaseID:	SPBC1683.08	Length:	557	Species:	Schizosaccharomyces pombe

Alignment Length:	492	Identity:	118/492 - (23%)
Similarity:	199/492 - (40%)	Gaps:	115/492 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LYSVAVSIFAIGGMLGGFSGGWMA---------NRFGRKGGLLLNN----------VLGIAGA-C 109
            |.||.|...::.|.|||...|.::         :||..:...:.|:          :.|...| |
pombe     5 LTSVLVVFISMAGWLGGADTGSISGILGMRDFQSRFADRYNPITNSYSYSAWRQALLTGTVNAGC 69

  Fly   110 LMG------FTK-VSHSYEMLF-----------------------LGRFIIGVNCGLNTSLVPMY 144
            |.|      ||: :...|.:.|                       :|:...|:..|..:.|.|.|
pombe    70 LFGAMLSSPFTEAIGKKYSIAFFSGCYIIGQILLVTAVPSWVQIMVGKLFTGLTIGALSVLSPGY 134

  Fly   145 ISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNE-----GWPILLGLAICPAILQLIL 204
            .||:||..:||.:.:..||..|.|.|::..:.    :||::     .|....|:.|...|..::.
pombe   135 QSEVAPPQIRGAVVSTYQLFQTCGTLIAACIN----MGTHKLRKTASWRTSFGINILWGIFLMVG 195

  Fly   205 LPVCPESPRYLLITKQWEEEARKALRRLRA-----------SGSVEEDIEEMRAEERAQQSESHI 258
            :...|||||| ||.|..:|||.:.:.:...           ..:::.|||...|..:|:..|
pombe   196 VLFLPESPRY-LIYKGRDEEALRIMCQTAELDPESEIIQTNFNTIKSDIEMEMAGGKARWPE--- 256

  Fly   259 STMELICSPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVM 323
                 :....:|...::|.:..|.::..|.|..|||:|.:|..:|:|:  .....:.:|||....
pombe   257 -----VFGKEVRYRTVLGFLTMLLRELIGNNYYFYYATQVFKGTGMTD--IFLPAVILGAINFGT 314

  Fly   324 TLVSIPLMDRTGRRTLHLYGLGGMFIFSIFITISFLI------KEMIDWMSY-----------LS 371
            |..::..:|..|||...::|       :.|.:|.|.|      :::|    |           :.
pombe   315 TFGALYTIDNLGRRNPLIFG-------AAFQSICFFIYAAVGDRKLI----YKNGTSDHRAGAVM 368

  Fly   372 VVATLGFVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALE--- 433
            :|.:..|:..:....|.:.|:|..|.|....|....|:|...||:.||:|....|.:..::.
pombe   369 IVFSCLFLFSYCCSWGPMGWVIVGETFPIRYRSKCAAVATSGNWLGNFMVSFFTPFISNSIGFKL 433

  Fly   434 NYTFLPFSVFLAIFWIFTYKKVPETKNKTFEEILALF 470
            .|.:...::..| |.||...|  |||..|.||:..|:
pombe   434 GYIYACINMTSA-FQIFLMAK--ETKGLTLEEVNELY 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	110/472 (23%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	117/490 (24%)
ght4	NP_595064.1	Sugar_tr	9..467	CDD:278511	114/486 (23%)
ght4	NP_595064.1	MFS	10..440	CDD:119392	103/455 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	2	1.900