DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and Slc2a2

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_037011.2	Gene:	Slc2a2 / 25351	RGDID:	3705	Length:	522	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	212/499 - (42%)
Similarity:	316/499 - (63%)	Gaps:	34/499 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LTFFLTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVY------------------------ 49
            :|..|.:::|:||||..||||:.||||||::.|.:..:.|.
  Rat     6 ITGTLAFTVFTAVLGSFQFGYDIGVINAPQEVIISHYRHVLGVPLDDRRATINYDINGTDTPLIV 70

  Fly    50 ------KDRYGEDI--SEEFIQQLYSVAVSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIA 106
                  .|.:.|:.  |...:..|:|::||.||:|||:..|.|||:.::.||...:|..|.|.:.
  Rat    71 TPAHTTPDAWEEETEGSAHIVTMLWSLSVSSFAVGGMVASFFGGWLGDKLGRIKAMLAANSLSLT 135

  Fly   107 GACLMGFTKVSHSYEMLFLGRFIIGVNCGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLL 171
            ||.|||.:|...::.::..||.:.|:.|||.:.||||||.||||..|||.|||::|||:..|:|:
  Rat   136 GALLMGCSKFGPAHALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGALGTLHQLALVTGILI 200

  Fly   172 SQVLGIEQILGTNEGWPILLGLAICPAILQLILLPVCPESPRYLLITKQWEEEARKALRRLRASG 236
            ||:.|:..|||..:.|.|||||:..||:||.:||..||||||||.:..:.|..|:|:|:|||.:.
  Rat   201 SQIAGLSFILGNQDYWHILLGLSAVPALLQCLLLLFCPESPRYLYLKLEEEVRAKKSLKRLRGTE 265

  Fly   237 SVEEDIEEMRAEERAQQSESHISTMELICSPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMS 301
            .|.:||.|||.|:....:|..:|.::|...|..|.|:::.:::.|:|||||||.:||||||:|.:
  Rat   266 DVTKDINEMRKEKEEASTEQKVSVIQLFTDPNYRQPIVVALMLHLAQQFSGINGIFYYSTSIFQT 330

  Fly   302 SGLTEESAKFATIGIGAIMVVMTLVSIPLMDRTGRRTLHLYGLGGMFIFSIFITISFLIKEMIDW 366
            :|:::  ..:||||:|||.::.|.||:.|:::.|||||.|.|:.|||..::|:::..::.:...|
  Rat   331 AGISQ--PVYATIGVGAINMIFTAVSVLLVEKAGRRTLFLAGMIGMFFCAVFMSLGLVLLDKFTW 393

  Fly   367 MSYLSVVATLGFVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTA 431
            |||:|:.|...||.||.:|||.|||.:.||.|||||||:|:|:|...||:.||::.:.|..:...
  Rat   394 MSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVCNFIIALCFQYIADF 458

  Fly   432 LENYTFLPFSVFLAIFWIFTYKKVPETKNKTFEEILALFRHNNG 475
            |..|.|..|:..:.||.:||:.||||||.|:|:||.|.||..:|
  Rat   459 LGPYVFFLFAGVVLIFTLFTFFKVPETKGKSFDEIAAEFRKKSG 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	195/466 (42%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	207/483 (43%)
Slc2a2	NP_037011.2	MFS_GLUT_Class1	12..488	CDD:340989	202/477 (42%)
Slc2a2	NP_037011.2	Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	312..318		5/5 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	485	1.000	Domainoid score	I377
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	1	1.000	-	-		otm45772
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.720